US2004116032A1PendingUtilityA1

Electroprocessed collagen

50
Priority: Feb 25, 1999Filed: Jul 29, 2003Published: Jun 17, 2004
Est. expiryFeb 25, 2019(expired)· nominal 20-yr term from priority
Inventors:Gary BowlinGary WnekDavid Simpson
C12N 5/0068A61F 2/08A61K 2035/126A61L 15/32A61L 27/18A61L 27/24A61L 27/26A61L 27/34A61L 27/38A61L 27/507A61L 31/041A61L 2430/30B29C 41/006B29C 67/0007C07K 14/78C12N 5/0012C12N 2533/40C12N 2533/54D01D 5/0038D01F 4/00Y10T442/696
50
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Claims

Abstract

A matrix of collagen is obtained through the method of electroprocessing. As a common natural polymer, collagen may be electroprocessed to form a matrix for multiple different applications.. The flexibility and variability of the processing allows the collagen matrix to be predesigned to meet many applications. These applications are included, but not limited to, biomedical applications, manufactured leather applications, food casing products, and footwear and clothing products.

Claims

exact text as granted — not AI-modified
What is claimed is:  
     
         1 . The product of the process of electroprocessing collagen.  
     
     
         2 . The product described in  claim 1 , wherein the process of electroprocessing comprises electrospinning collagen fibers.  
     
     
         3 . The product described in  claim 1 , wherein the process of electroprocessing comprises electrospraying collagen droplets.  
     
     
         4 . The product described in  claim 1 , wherein the collagen comprises synthetically manufactured collagen.  
     
     
         5 . A method for making a matrix of collagen comprising: 
 providing a substrate,    providing a reservoir of solution comprising collagen wherein the reservoir has an orifice that allows the solution to leave the reservoir,    electrically charging either the substrate or the solution, and grounding the other of the substrate or the solution that is not electrically charged, and streaming the collagen onto the substrate to form a matrix.    
     
     
         6 . The method described in  claim 5 , wherein the step of streaming the collagen onto the substrate forms a matrix of collagen fibers.  
     
     
         7 . The method described in  claim 5 , wherein the step of streaming the collagen onto the substrate forms a matrix of collagen droplets.  
     
     
         8 . The method described in  claim 5  wherein the substrate defines a preselected shape.  
     
     
         9 . The method described in  claim 5 , further comprising treating the collagen matrix with a cross-linking agent.  
     
     
         10 . The method described in  claim 5 , wherein the collagen comprises synthetically manufactured collagen.  
     
     
         11 . The method described in  claim 5 , wherein the collagen comprises a subset of a collagen molecule.  
     
     
         12 . A method for making a matrix of collagen comprising: 
 providing a substrate,    providing a target,    providing a reservoir of solution comprising collagen wherein the reservoir has an orifice that allows the solution to leave the reservoir,    electrically charging either the target or the solution, and grounding the other of the target or solution that is not electrically charged,    disposing the substrate between the orifice and the target, and streaming the collagen onto the substrate to form a matrix.    
     
     
         13 . The method described in  claim 12 , wherein the step of streaming the collagen onto the substrate forms a matrix of collagen fibers.  
     
     
         14 . The method described in  claim 12 , wherein the step of streaming the collagen onto the substrate forms a matrix of collagen droplets.  
     
     
         15 . The method described in  claim 12 , wherein the substrate defines a preselected shape.  
     
     
         16 . The method described in  claim 12 , further comprising treating the collagen matrix with a cross-linking agent.  
     
     
         17 . The method described in  claim 12 , wherein the collagen comprises synthetically manufactured collagen.  
     
     
         18 . The method described in  claim 12 , wherein the collagen comprises a subset of a collagen molecule.  
     
     
         19 . A food casing comprising a matrix of electroprocessed collagen.  
     
     
         20 . The food casing described in  claim 19 , wherein the collagen comprises electrospun collagen fibers.  
     
     
         21 . The food casing described in  claim 19 , wherein the collagen comprises electrosprayed collagen droplets.  
     
     
         22 . The food casing described in  claim 19 , wherein the collagen is cross-linked.  
     
     
         23 . A method of making a food casing comprising electroprocessing a matrix of collagen.  
     
     
         24 . Manufactured leather comprising a matrix of electroprocessed collagen.  
     
     
         25 . The manufactured leather described in  claim 24 , wherein the collagen comprises electrospun collagen fibers.  
     
     
         26 . The manufactured leather described in  claim 24 , wherein the collagen comprises electrosprayed collagen droplets.  
     
     
         27 . The manufactured leather described in  claim 24 , wherein the collagen is cross-linked.  
     
     
         28 . A method of manufacturing leather comprising electroprocessing a matrix of collagen.  
     
     
         29 . The method described in  claim 28 , further comprising the step of treating the collagen matrix with a cross-linking agent.

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