Human IRAK-2

Abstract

The present invention relates to a novel IRAK-2 protein which is a member of the IL-1 signaling pathway. In particular, isolated nucleic acid molecules are provided encoding the human IRAK-2 protein. IRAK-2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic methods for detecting IRAK-2 related disorders and therapeutic methods for treating IRAK-2 related disorders.

What is claimed is:  
     
         1 . An isolated nucleic acid molecule comprising a polynucleotide at least 95% identical to a nucleotide sequence encoding amino acids 1 to 96 of SEQ ID NO:2.  
     
     
         2 . The isolated nucleic acid molecule of  claim 1 , comprising a polynucleotide encoding amino acids 1 to 96 of SEQ ID NO:2.  
     
     
         3 . The isolated nucleic acid molecule of  claim 2 , comprising nucleotides 34 to 321 of SEQ ID NO:1.  
     
     
         4 . The isolated nucleic acid molecule of  claim 1 , which is DNA.  
     
     
         5 . The isolated nucleic acid molecule of  claim 1 , which is RNA.  
     
     
         6 . The isolated nucleic acid molecule of  claim 1 , further comprising a heterologous polynucleotide.  
     
     
         7 . The isolated nucleic acid molecule of  claim 6 , wherein said heterologous polynucleotide encodes a polypeptide.  
     
     
         8 . A recombinant vector comprising the isolated nucleic acid molecule of  claim 1 .  
     
     
         9 . A genetically engineered host cell that comprises the isolated nucleic acid molecule of  claim 1 .  
     
     
         10 . A genetically engineered host cell that comprises the polynucleotide of  claim 1  operatively associated with a regulatory sequence that controls gene expression.  
     
     
         11 . A recombinant method for producing an IRAK-2 polypeptide, comprising culturing the recombinant host cell of  claim 10  under conditions such that said polypeptide is expressed and recovering said polypeptide.  
     
     
         12 . A recombinant polypeptide produced by the method of  claim 11 .  
     
     
         13 . An isolated polypeptide comprising an amino acid sequence at least 95% identical to amino acids 1 to 96 of SEQ ID NO:2.  
     
     
         14 . The isolated polypeptide of  claim 13 , comprising amino acids 1 to 96 of SEQ ID NO:2.  
     
     
         15 . The isolated polypeptide of  claim 13 , further comprising a heterologous polypeptide.