Injectable composition for cancer treatment

Abstract

An intravenous pharmaceutical composition comprising an aqueous solution of arsenic trioxide and sodium chloride. The composition is effective in the treatment of cancers including leukemia. Complete remission of up to 21 years have been observed for acute promyclocytic leukemia patients.

I claim:  
     
         2 . (New) An intravenous pharmaceutical composition comprising an aqueous solution of arsenic trioxide and sodium chloride.  
     
     
         3 . (New) An intravenous pharmaceutical composition of  claim 2  comprising 1 g to 10 g of arsenic trioxide, 8 g of sodium chloride dissolved in 1000 mL of water.  
     
     
         4 . (New) An intravenous pharmaceutical composition according to  claim 3  comprising 10 g of arsenic trioxide.  
     
     
         5 . (New) An intravenous pharmaceutical composition comprising 10 mL of the composition of  claim 4  dissolved in 500 mL of 10 wt % glucose solution.  
     
     
         6 . (New) A process of preparing an intravenous composition according to  claim 2  comprising: 
 a. boiling sterile water;  
 b. adding arsenic trioxide to the boiling water and continuing to boil the mixture until all of the arsenic trioxide has completely dissolved;  
 c. adding sodium chloride to the boiling mixture; and  
 d. filtering the solution to ensure sterility and injectability.  
 
     
     
         7 . (New) A process of preparing the intravenous composition of  claim 2  comprising: 
 a. boiling 1000 mL of sterile water for injection;  
 b. adding 1 g to 10 g of arsenic trioxide to the boiling water and continuing to boil the mixture until the arsenic trioxide has completely dissolved;  
 c. adding 8 g of sodium chloride to the boiling mixture;  
 d. g.s. with sterile water for injection to 100 mL; and  
 e. filtering the solution through a G3 glass filter funnel to ensure sterility and injectability.  
 
     
     
         8 . (New) A process according to  claim 7  wherein 10 g of arsenic trioxide is added to the boiling water.  
     
     
         9 . (New) A process according to  claim 8  wherein 10 mL of the filtered solution from step d is added to 500 mL of 10 wt % glucose solution.  
     
     
         10 . (New) A method of treating cancer by administering by intravenous drip, a composition of  claim 5.