Composition and method for the treatment of onychomycosis in animals

Abstract

This invention relates to a composition and method for the treatment of white line disease, including ailments such as onychomycosis, sporotichosis, hoof rot, jungle rot, pseudallecheria boydii , scopulariopsis or athletes foot. The composition of the present invention is useful for the treatment of fungal infections such as onychomycosis in warm blooded animals such as humans and horses. The method of the present invention is directed to the application of a therapeutic amount of the present composition.

1 . A composition for the treatment of an animal afflicted with onycomychosis, the composition comprising:  
       
         
           
           
               
               
           
         
         Where R 1  is hydrogen, alkyl, hetero, heteroalkyl, aryl or heteroaryl;  
         R 3  is hydroxy, alkyl, hetero, heteroalkyl, aryl or heteroaryl;  
         R 2  is hetero;  
         each r 7  is independently hydrogen, alkyl, hetero, heteroalkyl, aryl or heteroaryl and;  
         a copper composition;  
         a peroxide;  
         a polyhydroxy aromatic compound;  
         a transition metal coordination composition;  
         all admixed in a hydrophyllic carrier composition.  
       
     
     
         2 . The composition according to  claim 1  wherein R 2  is oxygen.  
     
     
         3 . The composition according to  claim 2  wherein the copper composition is a copper complex.  
     
     
         4 . The composition according to  claim 3  wherein the copper complex is a diamine polymer-copper complex.  
     
     
         5 . The composition according to  claim 1  wherein the coordination composition is a Co chelate or complex.  
     
     
         6 . The composition according to  claim 1  wherein the coordination composition is a Zn chelate or complex.  
     
     
         7 . The composition according to  claim 1  wherein the coordination composition is a Fe chelate or complex.  
     
     
         8 . The composition according to  claim 1  wherein the polyhydoxy aromatic compound is a 1,2,4,5-tetra hydroxy benzene.  
     
     
         9 . The composition according to  claim 1  wherein the peroxide is an organic peroxide.  
     
     
         10 . The composition according to  claim 1  wherein the peroxide is an inorganic peroxide.  
     
     
         11 . The composition according to  claim 1  wherein the peroxide is hydrogen peroxide.  
     
     
         12 . The composition according to  claim 1  wherein the hydrophyllic carrier is between about 50% to about 99% by weight water.  
     
     
         13 . The composition according to  claim 1  wherein the hydrophyllic carrier is between about 1% to about 50% a compound according to formula II  
       
         
           
           
               
               
           
         
         wherein R 4  is a heteroatom, R 5  is a heteroalkyl or heteroatom-H and R 6  is —CH 3 ,alkylaryl, aryl or heteroaryl and n and x are independently between 1 and 20.  
       
     
     
         14 . The composition according to  claim 1  wherein the hydrophyllic carrier is between about 0.1% to about 30% by weight alcohol.  
     
     
         15 . A pharmaceutical composition for the topical treatment of onychomychosis comprising a composition according to  claim 1  and a pharmaceutically acceptable carrier.  
     
     
         16 . A method for the treatment of white line disease comprising: 
 applying to an afflicted area the whiteline treating composition according to  claim 1 .    
     
     
         17 . the method according to  claim 16  further comprising cleaning of the afflicted area prior to application of the whiteline treating composition.  
     
     
         18 . The method according to  claim 17  wherein cleaning of the afflicted area consists essentially of debrideing.  
     
     
         19 . A method of preventing whiteline disease comprising the steps of: 
 a) applying to a site in need of treatment a suitable amount of a whiteline treating composition according to  claim 1;     b) applying to the site a barrier composition.    
     
     
         20 . The method according to  claim 19  wherein the barrier composition is a barrier to water.  
     
     
         21 . The method according to  claim 19  wherein the barrier composition is a barrier to oxygen.  
     
     
         22 . The method according to  claim 19  further comprising cleaning the site prior to application of the whiteline treating composition.  
     
     
         23 . The method according to  claim 22  wherein the cleaning of the site comprises the steps of: 
 i) applying a cleaning composition to the afflicted area;  
 ii) causing at least a partial removal of the afflicted tissue.  
 
     
     
         24 . The method according to  claim 23  wherein steps I and ii are repeated.  
     
     
         25 . The method according to  claim 23  wherein the cleaning composition is a surfactant.  
     
     
         26 . The method according to  claim 23  wherein the cleaning composition contains an enzymatic composition.