Benzamide derivative and medicament containing the same

Abstract

A novel benzamide derivative represented by the following general formula: wherein R represents an alkyl group having 3 to 6 carbon atoms or a salt thereof, and a medicament comprising said derivative as an active ingredient. The medicament has excellent enhancing action on gastrointestinal tract motility, and is orally available with reduced side effects. Therefore, the medicament is extremely useful as an agent for therapeutic treatment of digestive diseases, an agent for improving function of gastrointestinal tract motility and the like.

What is claimed is:  
     
         1 . A compound represented by the following general formula:  
       
         
           
           
               
               
           
         
       
       wherein R represents an alkyl group having 3 to 6 carbon atoms, or a salt thereof.  
     
     
         2 . The compound or the salt thereof according to  claim 1  wherein R is a straight or branched chain alkyl group having 3 to 6 carbon atoms.  
     
     
         3 . The compound or the salt thereof according to  claim 1  wherein R is a straight or branched chain alkyl group having 4 to 5 carbon atoms.  
     
     
         4 . The compound or the salt thereof according to  claim 1  wherein R is n-butyl group or n-pentyl group.  
     
     
         5 . A medicament which comprises a compound or a physiologically acceptable salt thereof according to  claim 1  as an active ingredient.  
     
     
         6 . The medicament according to  claim 5  which is used for therapeutic and/or preventive treatment of a digestive disease.  
     
     
         7 . The medicament according to  claim 5  which is used for improvement of function of gastrointestinal tract motility.  
     
     
         8 . An agent for improving function of gastrointestinal tract motility which comprises a compound or a physiologically acceptable salt thereof according to  claim 1  as an active ingredient.  
     
     
         9 . A use of a compound or a physiologically acceptable salt thereof according to  claim 1  for a manufacture of a medicament.  
     
     
         10 . A method for therapeutic and/or preventive treatment of a digestive disease which comprises the step of administering to a mammal including a human a therapeutically and/or preventively effective amount of a compound or a physiologically acceptable salt thereof according to  claim 1 .  
     
     
         11 . A method for improving function of gastrointestinal tract motility which comprises the step of administering to a mammal including a human a therapeutically and/or preventively effective amount of a compound or a physiologically acceptable salt thereof according to  claim 1.