Medicinal product packaging

Abstract

A packaged medicinal product comprising a medicinal preparation packaged in a plastic container having a fluorinated barrier layer on a surface of its body wall is disclosed. The fluorinated barrier layer on the surface of container body wall reduces the loss of an ingredient in the medicinal preparation through the container body wall, and reduces the transfer of impurities into the medicinal preparation from the container materials, from label-related materials, or from the environment where the packaged medicinal preparation is stored.

What is claimed is:  
     
         1 . A packaged medicinal product having extended shelf-life comprising: 
 (a) a medicinal preparation; and    (b) a plastic container having a fluorinated barrier layer on a surface of the body wall,    wherein the body of the container is fill with the medicinal preparation.    
     
     
         2 . A packaged medicinal product according to  claim 1 , wherein the medicinal preparation is a liquid.  
     
     
         3 . A packaged medicinal product according to  claim 2 , wherein the medicinal preparation comprises a highly potent ingredient.  
     
     
         4 . A packaged medicinal product according to  claim 3 , wherein the highly potent ingredient is a prostaglandin.  
     
     
         5 . A packaged medicinal product according to  claim 1 , wherein the container is made of materials comprising LDPE, HDPE or PP.  
     
     
         6 . A packaged medicinal product according to  claim 5 , wherein the container is a small volume bottle.  
     
     
         7 . A packaged medicinal product according to  claim 6 , wherein the medicinal preparation comprises a prostaglandin.  
     
     
         8 . A packaged medicinal product according to  claim 7 , which is for ophthalmic use.  
     
     
         9 . A method of packaging a medicinal preparation, said method comprising the steps of: 
 (a) providing a plastic container having a fluorinated barrier layer on a surface of its body wall; and    (b) filling the container body with the medicinal preparation.    
     
     
         10 . The method according to  claim 9 , wherein the medicinal preparation is a liquid.  
     
     
         11 . The method according to  claim 10 , wherein the medicinal preparation comprises a highly potent ingredient.  
     
     
         12 . The method according to  claim 11 , wherein the highly potent ingredient is a prostaglandin.  
     
     
         13 . The method according to  claim 9 , wherein the container is made of materials comprising LDPE, PP, HDPE.  
     
     
         14 . The method according to  claim 13 , wherein the container is a small volume bottle.  
     
     
         15 . The method according to  claim 14 , wherein the medicinal preparation comprises a prostaglandin.  
     
     
         16 . The method according to  claim 15 , wherein the medicinal preparation is for ophthalmic use.  
     
     
         17 . A method of increasing the stability of a liquid medicinal preparation, said method comprising packaging the liquid medicinal preparation in a plastic container having a fluorinated barrier layer on a surface of the container body wall.  
     
     
         18 . The method according to  claim 17 , wherein the plastic container is made of materials comprising LDPE, PP, HDPE.  
     
     
         19 . The method according to  claim 18 , wherein the liquid medicinal preparation comprises a highly potent ingredient.  
     
     
         20 . The method according to  claim 19 , wherein the highly potent ingredient is a prostaglandin.  
     
     
         21 . The method according to  claim 20 , wherein the medicinal preparation is for ophthalmic use.  
     
     
         22 . A method of preventing loss of an ingredient in a liquid medicinal preparation through the wall of a plastic container which contains the medicinal preparations, said method comprising packaging the medicinal preparation in the plastic container said container having has a fluorinated barrier layer on a surface of the container body wall.  
     
     
         23 . The method according to  claim 22 , wherein the plastic container is made of materials comprising LDPE, PP, HDPE.  
     
     
         24 . The method according to  claim 22 , wherein the liquid medicinal preparation comprises a highly potent ingredient.  
     
     
         25 . The method according to  claim 24 , wherein the highly potent ingredient is a prostaglandin.  
     
     
         26 . The method according to  claim 25 , wherein the medicinal preparation is for ophthalmic use.  
     
     
         27 . The method according to  claim 22 , wherein the container has a fluorinated barrier layer on the inside surface of the container body wall.  
     
     
         28 . A method of reducing transfer of an impurity into a liquid medicinal preparation upon storage, comprising packaging the liquid medicinal preparation in a plastic container said container having a fluorinated barrier layer on a surface of the container body wall.  
     
     
         29 . The method according to  claim 28 , wherein the plastic container is made of materials comprising LDPE, PP, HDPE.  
     
     
         30 . The method according to  claim 28 , wherein the liquid medicinal preparation comprises a highly potent ingredient.  
     
     
         31 . The method according to  claim 30 , wherein the highly potent ingredient is a prostaglandin.  
     
     
         32 . The method according to  claim 31 , wherein the medicinal preparation is for ophthalmic use.  
     
     
         33 . The method according to  claim 28 , wherein the container has a fluorinated barrier layer on the inside surface of the container body wall.