Admixture of extracts of plants of the genus rosmarinus and carotenoids for treating cutaneous symptoms of aging

Abstract

Intimate admixtures of at least one carotenoid and at least one extract of at least one plant of the genus Rosmarinus are well suited for treating the undesirable cutaneous signs of skin aging, in particular the determination of the skin and/or of the mucous membranes by inhibiting the activity and/or the expression of collagenases and by increasing the synthesis of collagen.

What is claimed is:  
     
         1 . A regime or regimen for treating the cutaneous signs of skin aging, comprising administering to a mammal in need of such treatment, a thus effective amount of a cosmetic/dermatological composition which comprises intimate admixture of at least one carotenoid and at least one extract of at least one plant of the genus Rosmarinus.  
     
     
         2 . A regime or regimen for combating the degradation of collagen, comprising administering to a mammal in need of such treatment, a thus effective amount of a cosmetic/dermatological composition which comprises intimate admixture of at least one carotenoid and at least one extract of at least one plant of the genus Rosmarinus.  
     
     
         3 . A regime or regimen for inhibiting the expression of the proteases of the extracellular matrix, comprising administering to a mammal in need of such treatment, a thus effective amount of a cosmetic/dermatological composition which comprises intimate admixture of at least one carotenoid and at least one extract of at least one plant of the genus Rosmarinus.  
     
     
         4 . The regime or regimen as defined by  claim 3 , for inhibiting the expression of metalloproteinases.  
     
     
         5 . The regime or regimen as defined by  claim 4 , for inhibiting the expression of metalloproteinase type 1.  
     
     
         6 . A regime or regimen for treating conditions of the skin resulting from menopause, comprising administering to a mammal in need of such treatment, a thus effective amount of a cosmetic/dermatological composition which comprises intimate admixture of at least one carotenoid and at least one extract of at least one plant of the genus Rosmarinus.  
     
     
         7 . A regime or regimen for combating skin wrinkles and fine lines, comprising administering to a mammal in need of such treatment, a thus effective amount of a cosmetic/dermatological composition which comprises intimate admixture of at least one carotenoid and at least one extract of at least one plant of the genus Rosmarinus.  
     
     
         8 . A regime or regimen for combating withered skin, comprising administering to a mammal in need of such treatment, a thus effective amount of a cosmetic/dermatological composition which comprises intimate admixture of at least one carotenoid and at least one extract of at least one plant of the genus Rosmarinus.  
     
     
         9 . A regime or regimen for combating soft skin, comprising administering to a mammal in need of such treatment, a thus effective amount of a cosmetic/dermatological composition which comprises intimate admixture of at least one carotenoid and at least one extract of at least one plant of the genus Rosmarinus.  
     
     
         10 . A regime or regimen for combating skin with a reduced thickness, comprising administering to a mammal in need of such treatment, a thus effective amount of a cosmetic/dermatological composition which comprises intimate admixture of at least one carotenoid and at least one extract of at least one plant of the genus Rosmarinus.  
     
     
         11 . A regime or regimen for combating dull skin or skin with no brightness, comprising administering to a mammal in need of such treatment, a thus effective amount of a cosmetic/dermatological composition which comprises intimate admixture of at least one carotenoid and at least one extract of at least one plant of the genus Rosmarinus.  
     
     
         12 . A regime or regimen for treating skin damaged by exposure to ultraviolet radiation, comprising administering to a mammal in need of such treatment, a thus effective amount of a cosmetic/dermatological composition which comprises intimate admixture of at least one carotenoid and at least one extract of at least one plant of the genus Rosmarinus.  
     
     
         13 . A regime or regimen for inhibiting the activity and/or the expression of collagenases and by increasing the synthesis of collagen, comprising administering to a mammal in need of such treatment, a thus effective amount of a cosmetic/dermatological composition which comprises intimate admixture of at least one carotenoid and at least one extract of at least one plant of the genus Rosmarinus.  
     
     
         14 . A cosmetic/dermatological composition suited for treating the undesirable cutaneous signs of skin aging, comprising intimate admixture of thus effective amounts of at least one carotenoid and at least one extract of at least one plant of the genus Rosmarinus, formulated into a cosmetically/dermatologically acceptable carrier therefor.  
     
     
         15 . The cosmetic/dermatological composition as defined by  claim 14 , said at least one carotenoid comprising a carotenoid having provitamin A activity, a carotenoid devoid of provitamin A activity, or mixture thereof.  
     
     
         16 . The cosmetic/dermatological composition as defined by  claim 15 , said at least one carotenoid comprising β-carotene, a-carotene, or mixture thereof.  
     
     
         17 . The cosmetic/dermatological composition as defined by  claim 16 , said at least one carotenoid comprising β-carotene.  
     
     
         18 . The cosmetic/dermatological composition as defined by  claim 15 , said at least one carotenoid comprising zeaxanthin, cryptoxanthin, lutein, lycopene, or mixture thereof.  
     
     
         19 . The cosmetic/dermatological composition as defined by  claim 18 , said at least one carotenoid comprising lycopene.  
     
     
         20 . The cosmetic/dermatological composition as defined by  claim 14 , said at least one carotenoid comprising from 10-12% to 20% by weight thereof.  
     
     
         21 . The cosmetic/dermatological composition as defined by  claim 14 , said at least one carotenoid comprising from 10 −10 % to 10% by weight thereof.  
     
     
         22 . The cosmetic/dermatological composition as defined by  claim 14 , said at least one extract of at least one plant of the genus Rosmarinus having been derived from a whole plant or from a plant portion.  
     
     
         23 . The cosmetic/dermatological composition as defined by  claim 22 , said at least one extract of at least one plant of the genus Rosmarinus having been derived from plant leaves, stems, flowers, petals, roots, or dedifferentiated cells.  
     
     
         24 . The cosmetic/dermatological composition as defined by  claim 23 , said at least one extract of at least one plant of the genus Rosmarinus having been derived from plant leaves.  
     
     
         25 . The cosmetic/dermatological composition as defined by  claim 14 , said at least one extract of at least one plant of the genus Rosmarinus having been cultivated in vivo or in vitro.  
     
     
         26 . The cosmetic/dermatological composition as defined by  claim 25 , said at least one extract of at least one plant of the genus Rosmarinus having been cultivated in vivo.  
     
     
         27 . The cosmetic/dermatological composition as defined by  claim 14 , said at least one extract of at least one plant of the genus Rosmarinus comprising an aqueous extract.  
     
     
         28 . The cosmetic/dermatological composition as defined by  claim 14 , said at least one extract of at least one plant of the genus Rosmarinus comprising from 0.001% to 20% by weight thereof.  
     
     
         29 . The cosmetic/dermatological composition as defined by  claim 25 , said at least one extract of at least one plant of the genus Rosmarinus comprising from 0.01% to 10% by weight thereof.  
     
     
         30 . A cosmetic/dermatological composition suited for treating the undesirable cutaneous signs of skin aging, comprising intimate admixture of thus effective amounts of at least one carotenoid, at least one extract of at least one plant of the genus Rosmarinus and at least one other active agent for stimulating the synthesis of lipids and/or the proliferation of the keratinocrytes, formulated into a cosmetically/dermatologically acceptable carrier therefor.  
     
     
         31 . The cosmetic/dermatological composition as defined by  claim 30 , comprising at least one other active agent for stimulating the synthesis of lipids and which comprises a plant hormone, an auxin, a compound of plant origin, cinnamic acid or derivative thereof, or mixture thereof.  
     
     
         32 . The cosmetic/dermatological composition as defined by  claim 31 , comprising indoleacetic acid (IAA), 4-chloroindole-3-acetic acid (4-CI-IAA), phenylacetic acid (PAA), indole-3-butyric acid (IBA), 2,4-dichlorophenoxyacetic acid (2,4-D), α-naphthaleneacetic acid (α-NAA), β-naphthoxyacetic acid, indoleethanol, idoleacetaldehyde, indoleacetonitrile, or mixture thereof.  
     
     
         33 . The cosmetic/dermatological composition as defined by  claim 30 , comprising phloroglucinol.  
     
     
         34 . An orally administratable cosmetic/dermatological composition suited for treating the undesirable cutaneous signs of skin aging, comprising intimate admixture of thus effective amounts of at least one carotenoid and at least one extract of at least one plant of the genus Rosmarinus, formulated into an orally administratable, cosmetically/dermatologically acceptable carrier therefor.  
     
     
         35 . The cosmetic/dermatological composition as defined by  claim 34 , formulated as a solution, syrup, tablet, gelatin capsule, or nutritional food or supplement.  
     
     
         36 . A topically applicable cosmetic/dermatological composition suited for treating the undesirable cutaneous signs of skin aging, comprising intimate admixture of thus effective amounts of at least one carotenoid and at least one extract of at least one plant of the genus Rosmarinus, formulated into a topically applicable, cosmetically/dermatologically acceptable carrier therefor.  
     
     
         37 . The cosmetic/dermatological composition as defined by  claim 36 , formulated as a solution, emulsion, gel, paste, solid, spherules, vesicles, cream, ointment, milk, lotion, serum, foam, aerosol, makeup, or deodorant.  
     
     
         38 . The cosmetic/dermatological composition as defined by  claim 14 , further comprising at least one plant extract rich in isoflavonoids.  
     
     
         39 . The cosmetic/dermatological composition as defined by  claim 14 , further comprising vitamin C.  
     
     
         40 . The cosmetic/dermatological composition as defined by  claim 14 , further comprising α-tocopherol.  
     
     
         41 . The cosmetic/dermatological composition as defined by  claim 14 , comprising at least one extract of at least one plant of the genus Rosmarinus, lycopene, at least one plant extract rich in isoflavonoids, vitamin C and α-tocopherol.