US2004058004A1PendingUtilityA1

Suspensions of micronized fenofibrate

60
Priority: Jan 17, 1997Filed: Sep 22, 2003Published: Mar 25, 2004
Est. expiryJan 17, 2017(expired)· nominal 20-yr term from priority
Inventors:Andre StammPawan Seth
A61P 3/06A61P 3/04A61P 1/18A61K 9/1617A61K 9/16A61K 9/2081A61K 9/1635A61K 9/2054A61K 31/216A61K 9/1623A61K 9/2027A61K 31/12A61K 9/2077A61K 9/14A61K 31/215A61K 9/1676
60
PatentIndex Score
0
Cited by
0
References
0
Claims

Abstract

The invention provides suspensions of micronized fenofibrate in solutions comprising hydrophilic polymers and, optionally, surfactants.

Claims

exact text as granted — not AI-modified
What is claimed is:  
     
         1 . A suspension of micronized fenofibrate in a solution of at least one hydrophilic polymer, wherein the weight ratio of fenofibrate/hydrophilic polymer is between 1/10 and 4/1.  
     
     
         2 . The suspension according to  claim 1 , wherein the weight ratio of fenofibrate/hydrophilic polymer is between 1/2 and 2/1.  
     
     
         3 . The suspension according to  claim 1 , wherein the fenofibrate has a size less than 20 μm.  
     
     
         4 . The suspension according to  claim 1 , wherein the fenofibrate is present in an amount from 1 to 40% by weight.  
     
     
         5 . The suspension according to  claim 4 , wherein the fenofibrate is present in an amount from 10 to 25% by weight.  
     
     
         6 . The suspension according to  claim 1 , wherein the hydrophilic polymer is present in an amount from 5 to 40% by weight.  
     
     
         7 . The suspension according to  claim 6 , wherein the hydrophilic polymer is present in an amount from 10 to 25% by weight.  
     
     
         8 . The suspension according to  claim 1 , wherein the hydrophilic polymer is a polyvinylpyrrolidone, a poly(vinyl alcohol), a hydroxypropylcellulose, a hydroxymethylcellulose, a hydroxypropylmethylcellulose, a gelatin, or a mixture of two or more thereof.  
     
     
         9 . The suspension according to  claim 8 , wherein the hydrophilic polymer is a polyvinylpyrrolidone.  
     
     
         10 . The suspension according to  claim 1 , further comprising at least one surfactant.  
     
     
         11 . The suspension according to  claim 10 , wherein the surfactant is present in an amount up to 10% by weight.  
     
     
         12 . The suspension according to  claim 11 , wherein the surfactant is present in an amount up to 5% by weight.  
     
     
         13 . The suspension according to  claim 10 , wherein the weight ratio of surfactant/hydrophilic polymer is between 1/500 and 1/10.  
     
     
         14 . The suspension according to  claim 13 , wherein the weight ratio of surfactant/hydrophilic polymer is between 1/100 and 5/100.  
     
     
         15 . The suspension according to  claim 10 , wherein the surfactant is sodium lauryl sulfate, monooleate, monolaurate, monopalmitate, monostearate or another ester of polyoxyethylene sorbitane, sodium dioctylsulfosuccinate, lecithin, stearylic alcohol, cetostearylic alcohol, cholesterol, polyoxyethylene ricin oil, polyoxyethylene fatty acid glycerides, poloxamer, or a mixture of two or more thereof.  
     
     
         16 . The suspension according to  claim 15 , wherein the surfactant is sodium lauryl sulfate.  
     
     
         17 . The suspension according to  claim 10 , wherein the fenofibrate and surfactant are co-micronized.  
     
     
         18 . The suspension according to  claim 1 , wherein the hydrophilic polymer and surfactant are dissolved in the solution.  
     
     
         19 . A suspension of micronized fenofibrate in a solution of at least one hydrophilic polymer, wherein the weight ratio of fenofibrate/hydrophilic polymer is between 1/2 and 2/1, said hydrophilic polymer being polyvinylpyrrolidone.  
     
     
         20 . The suspension according to  claim 19 , further comprising at least one surfactant.  
     
     
         21 . The suspension according to  claim 20 , wherein the weight ratio of surfactant/hydrophilic polymer is between 1/500 and 1/10.  
     
     
         22 . The suspension according to  claim 20 , wherein the surfactant is sodium lauryl sulfate.  
     
     
         23 . The suspension according to  claim 19 , wherein the hydrophilic polymer and surfactant are dissolved in the solution.  
     
     
         24 . A suspension of micronized fenofibrate in a solution of at least one hydrophilic polymer and at least one surfactant.  
     
     
         25 . The suspension according to  claim 24 , wherein the weight ratio of surfactant/hydrophilic polymer is between 1/500 and 1/10.  
     
     
         26 . The suspension according to  claim 25 , wherein the weight ratio of surfactant/hydrophilic polymer is between 1/100 and 5/100.  
     
     
         27 . The suspension according to  claim 24 , wherein the surfactant is present in an amount up to 10% by weight.  
     
     
         28 . The suspension according to  claim 27 , wherein the surfactant is present in an amount up to 5% by weight.  
     
     
         29 . The suspension according to  claim 24 , wherein the surfactant is sodium lauryl sulfate, monooleate, monolaurate, monopalmitate, monostearate or another ester of polyoxyethylene sorbitane, sodium dioctylsulfosuccinate, lecithin, stearylic alcohol, cetostearylic alcohol, cholesterol, polyoxyethylene ricin oil, polyoxyethylene fatty acid glycerides, poloxamer, or a mixture of two or more thereof.  
     
     
         30 . The suspension according to  claim 29 , wherein the surfactant is sodium lauryl sulfate.  
     
     
         31 . The suspension according to  claim 24 , wherein the fenofibrate and surfactant are co-micronized.  
     
     
         32 . The suspension according to  claim 24 , wherein the weight ratio of fenofibrate/hydrophilic polymer is between 1/10 and 4/1.  
     
     
         33 . The suspension according to  claim 32 , wherein the weight ratio of fenofibrate/hydrophilic polymer is between 1/2 and 2/1.  
     
     
         34 . The suspension according to  claim 24 , wherein the fenofibrate has a size less than 20 μm.  
     
     
         35 . The suspension according to  claim 24 , wherein the fenofibrate is present in an amount from 1 to 40% by weight.  
     
     
         36 . The suspension according to  claim 35 , wherein the fenofibrate is present in an amount from 10 to 25% by weight.  
     
     
         37 . The suspension according to  claim 24 , wherein the hydrophilic polymer is present in an amount from 5 to 40% by weight.  
     
     
         38 . The suspension according to  claim 37 , wherein the hydrophilic polymer is present in an amount from 10 to 25% by weight.  
     
     
         39 . The suspension according to  claim 24 , wherein the hydrophilic polymer is a polyvinylpyrrolidone, a poly(vinyl alcohol), a hydroxypropylcellulose, a hydroxymethylcellulose, a hydroxypropylmethylcellulose, a gelatin, or a mixture of two or more thereof.  
     
     
         40 . The suspension according to  claim 39 , wherein the hydrophilic polymer is a polyvinylpyrrolidone.  
     
     
         41 . The suspension according to  claim 24 , wherein the hydrophilic polymer and surfactant are dissolved in the solution.  
     
     
         42 . A suspension of micronized fenofibrate in a solution of at least one hydrophilic polymer and at least one surfactant, said hydrophilic polymer being polyvinylpyrrolidone and said surfactant being sodium lauryl sulfate, and the weight ratio of surfactant/hydrophilic polymer being between 1/500 and 1/10.  
     
     
         43 . The suspension according to  claim 42 , wherein the weight ratio of fenofibrate/hydrophilic polymer is between 1/10 and 4/1.  
     
     
         44 . The suspension according to  claim 43 , wherein the weight ratio of fenofibrate/hydrophilic polymer is between 1/2 and 2/1.  
     
     
         45 . The suspension according to  claim 42 , wherein the fenofibrate has a size less than 20 μm.  
     
     
         46 . The suspension according to  claim 42 , wherein the hydrophilic polymer and surfactant are dissolved in the solution.  
     
     
         47 . A suspension of micronized fenofibrate in a solution of polyvinylpyrrolidone and of sodium lauryl sulfate, wherein the weight ratio of fenofibrate/polyvinylpyrrolidone is between 1/2 and 2/1 and the weight ratio of sodium lauryl sulfate/polyvinylpyrrolidone being between 1/500 and 1/10.  
     
     
         48 . The suspension according to  claim 47 , wherein the fenofibrate has a size less than 20 μm.  
     
     
         49 . The suspension according to  claim 47 , wherein the fenofibrate is present in an amount from 1 to 40% by weight.  
     
     
         50 . The suspension according to  claim 49 , wherein the fenofibrate is present in an amount from 10 to 25% by weight.  
     
     
         51 . The suspension according to  claim 47 , wherein the hydrophilic polymer is present in an amount from 5 to 40% by weight.  
     
     
         52 . The suspension according to  claim 51 , wherein the hydrophilic polymer is present in an amount from 10 to 25% by weight.  
     
     
         53 . The suspension according to  claim 47 , wherein the surfactant is present in an amount up to 10% by weight.  
     
     
         54 . The suspension according to  claim 53 , wherein the surfactant is present in an amount up to 5% by weight.  
     
     
         55 . The suspension according to  claim 47 , wherein the fenofibrate and surfactant are co-micronized.  
     
     
         56 . The suspension according to  claim 47 , wherein the hydrophilic polymer and surfactant are dissolved in the solution.  
     
     
         57 . The suspension according to  claim 1 , wherein the fenofibrate has a size less than 10 μm.  
     
     
         58 . The suspension according to  claim 19 , wherein the fenofibrate has a size less than 10 μm.  
     
     
         59 . The suspension according to  claim 24 , wherein the fenofibrate has a size less than 10 μm.  
     
     
         60 . The suspension according to  claim 42 , wherein the fenofibrate has a size less than 10 μm.  
     
     
         61 . The suspension according to  claim 47 , wherein the fenofibrate has a size less than 10 μm.

Join the waitlist — get patent alerts

Track US2004058004A1 — get alerts on status changes and closely related new filings.

We store only your email — no account needed. See our privacy policy.