US2004054414A1PendingUtilityA1

Collagen-based materials and methods for augmenting intervertebral discs

46
Priority: Sep 18, 2002Filed: Sep 18, 2002Published: Mar 18, 2004
Est. expirySep 18, 2022(expired)· nominal 20-yr term from priority
Inventors:Hai H. TrieuMichael C. Sherman
A61F 2002/445A61B 17/7064A61L 2430/24A61B 17/562A61F 2002/30224A61F 2210/0061A61F 2002/3008A61L 31/005A61F 2002/30075A61F 2/4601A61F 2002/30588A61L 27/3856A61L 27/24A61F 2002/30677A61L 2430/38A61L 27/36A61F 2250/0098A61L 31/18A61F 2/08A61F 2002/4627A61B 2017/564A61L 31/14A61F 2310/00365A61F 2230/0069A61F 2002/444A61L 27/50A61B 17/7095A61F 2/442
46
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Claims

Abstract

A method of augmenting an intervertebral disc by injecting particles of collagen-based material into the disc. The particles may be dehydrated before implantation, and rehydrated after implantation, or they may be implanted in a “wet” state—such as a slurry or gel. Radiocontrast materials may be included to enhance imaging of the injected material. Other additives may include analgesics, antibiotics, proteoglycans, growth factors, and/or other cells effective to promote healing and/or proper disc function.

Claims

exact text as granted — not AI-modified
What is claimed is:  
     
         1 . A method of augmenting an intervertebral disc, said method comprising surgically adding to an intervertebral disc a composition comprising particulate collagen-based material.  
     
     
         2 . The method of  claim 1  wherein said surgically adding step comprises injecting particulate collagen-based material into an intervertebral disc.  
     
     
         3 . The method of  claim 1  wherein said collagen-based material comprises particles ranging from 0.05 mm to 5 mm in size.  
     
     
         4 . The method of  claim 1  wherein said collagen-based material comprises particles ranging from 0.05 mm to 3 mm in size.  
     
     
         5 . The method of  claim 1  wherein said collagen-based material comprises particles ranging from 0.05 mm to 1 mm in size.  
     
     
         6 . The method of  claim 1  wherein said collagen-based material comprises particles ranging from 0.25 mm to 1 mm in size.  
     
     
         7 . The method of  claim 1  wherein said collagen-based material is injected in a dehydrated state.  
     
     
         8 . The method of  claim 1  wherein said collagen-based material is injected in a non-dehydrated state.  
     
     
         9 . The method of  claim 8  wherein said collagen-based material is injected as a gel.  
     
     
         10 . The method of  claim 8  wherein said collagen-based material is injected as a solution or suspension.  
     
     
         11 . The method of  claim 1  wherein said collagen-based material is provided as a formulation that additionally includes a cross-linking agent to promote crosslinking of collagen molecules.  
     
     
         12 . The method of  claim 1  wherein said collagen-based material is provided as a formulation that additionally includes a radiocontrast media.  
     
     
         13 . The method of  claim 1  wherein said collagen-based material is provided as a formulation that additionally includes an analgesic.  
     
     
         14 . The method of  claim 1  wherein said collagen-based material is provided as a formulation that additionally includes an antibiotic.  
     
     
         15 . The method of  claim 1  wherein said collagen-based material is provided as a formulation that additionally includes proteoglycans.  
     
     
         16 . The method of  claim 1  wherein said collagen-based material is provided as a formulation that additionally includes growth factors.  
     
     
         17 . The method of  claim 1  wherein said collagen-based material is provided as a formulation that additionally includes one or more other types of cells effective to promote healing, repair, regeneration and/or restoration of the disc, and/or to facilitate proper disc function.  
     
     
         18 . An intervertebral disc augmented with particulate collagen-based material.  
     
     
         19 . The augmented disc of  claim 18  wherein said collagen-based material comprises collagen-based material that has been injected into the disc.  
     
     
         20 . The augmented disc of  claim 18  wherein said collagen-based material comprises particles ranging from 0.05 mm to 5 mm in size.  
     
     
         21 . The augmented disc of  claim 18  wherein said collagen-based material comprises particles ranging from 0.05 mm to 3 mm in size.  
     
     
         22 . The augmented disc of  claim 18  wherein said collagen-based material comprises particles ranging from 0.05 mm to 1 mm in size.  
     
     
         23 . The augmented disc of  claim 18  wherein said collagen-based material comprises particles ranging from 0.25 mm to 1 mm in size.  
     
     
         24 . The augmented disc of  claim 18  wherein said collagen-based material comprises collagen-based materials that have been reconstituted in the disc from dehydrated collagen-based materials.  
     
     
         25 . The augmented disc of  claim 18  wherein said collagen-based material comprises collagen-based materials that were injected into the disc in a non-dehydrated state.  
     
     
         26 . The augmented disc of  claim 18  wherein said collagen-based material comprises collagen-based materials that were injected into the disc as a gel.  
     
     
         27 . The augmented disc of  claim 18  wherein said collagen-based material comprises collagen-based materials that were injected into the disc as a solution or suspension.  
     
     
         28 . The augmented disc of  claim 18  wherein said collagen-based material additionally includes a cross-linking agent to promote crosslinking of collagen molecules.  
     
     
         29 . The augmented disc of  claim 18  wherein said collagen-based material additionally includes a radiocontrast media.  
     
     
         30 . The augmented disc of  claim 18  wherein said collagen-based material additionally includes an analgesic.  
     
     
         31 . The augmented disc of  claim 18  wherein said collagen-based material additionally includes an antibiotic.  
     
     
         32 . The augmented disc of  claim 18  wherein said collagen-based material additionally includes proteoglycans.  
     
     
         33 . The augmented disc of  claim 18  wherein said collagen-based material additionally includes growth factors.  
     
     
         34 . The augmented disc of  claim 18  wherein said collagen-based material additionally includes one or more other types of cells effective to promote healing, repair, regeneration and/or restoration of the disc, and/or to facilitate proper disc function.

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