Preparation of fluid samples by applying pressure

Abstract

The present invention described a device which comprises: a first container having at least one hole or outlet means present in the bottom and/or sides of the first container; a second container; and a compressor or means to apply pressure where the device is constructed in such a way that it is able to squeeze or compress a sample present in the first container, and hence releases forces or separates fluid from the sample where the first container is constructed in such a way that some or all of the fluid separated from the sample will pass through the hole or outlet into the second container. The device allows the preparation of fluid samples from tissue in a reliable, reproducible inexpensive manner.

1 . A device which comprises: 
 a first container having at least one hole or outlet means present in the bottom and/or sides of the first container;    a second container; and    a compressor or means to apply pressure    where the device is constructed in such a way that it is able to squeeze or compress a sample present in the first container, and hence releases, forces or separates fluid    from the sample where the first container is constructed in such a way that some or all of the fluid separated from the sample will pass through the hole or outlet means into the second container.    
     
     
         2 . A device according to  claim 1 , wherein the second container is below the first 
 container and/or is joined by a conduit or means so as to allow fluid to pass to the second container.    
     
     
         3 . A device according to  claim 1  or  2  which comprises multiple first containers, second containers, compressors and/or holes or outlet means, preferably having at least two, preferably from 4 to 200, more preferably from 10 to 50 first containers, second containers and compressors.  
     
     
         4 . A device according to  claim 3 , wherein the first containers, second containers and compressors are grouped as a matrix.  
     
     
         5 . A device according to any one of the preceding claims where the holes in the first container have a diameter of from 0.1 to 0.8 cm.  
     
     
         6 . A device according to any one of the preceding claims, where at least part of an assay test for testing the fluid is present in or is in functional connection with the second container.  
     
     
         7 . A device according to any one of the preceding claims where a distance holder means is present which keeps a selected distance between the compressor and the bottom of the first container and/or which keeps a selected distance between the first and second containers.  
     
     
         8 . A device according to any one of the preceding claims wherein the device additionally includes means to microwave the samples.  
     
     
         9 . A device according to any one of the preceding claims wherein the sample is a tissue.  
     
     
         10 . Use of a device according to any one of the preceding claims to squeeze or compress a sample, preferably a tissue, more preferably an animal tissue, to produce a liquid.