Two-chamber cartridge for propellant-free metering aerosols

Abstract

The invention relates to a two-chamber cartridge for drug formulations for propellant-free inhalers.

1 . Cartridge for propellant-free metering aerosols consisting of a container ( 4 ) with closure cap ( 3 ) for holding liquids, wherein a device ( 5 ) is provided which displaces some of the contents of the container as the closure cap ( 3 ) is pushed onto the neck of the container ( 4 ), characterised in that the closure cap ( 3 ) contains at least one chamber ( 2 ), the chamber ( 2 ) being sealed off from the outside and from the interior of the container ( 4 ) by two pierceable partitions ( 13 ) and ( 14 ).  
     
     
         2 . Cartridge according to  claim 1 , characterised in that the chamber ( 2 ) contains a pharmaceutical composition.  
     
     
         3 . Cartridge according to  claim 2 , characterised in that the container ( 4 ) contains a solvent.  
     
     
         4 . Cartridge according to  claims 1  to  3 , characterised in that the chamber ( 2 ) contains an active substance which is suitable for administration by inhalation.  
     
     
         5 . Cartridge according to  claims 1  to  4 , characterised in that the active substance is present in the form of a tablet.  
     
     
         6 . Cartridge according to one of the preceding claims, characterised in that the partition of the chamber ( 2 ) to the outside is constructed as a septum ( 13 ) and the partition to the inner container is constructed as a sealing film ( 14 ).  
     
     
         7 . Cartridge according to one of  claims 1  to  6 , characterised in that the chamber ( 2 ) has frangible points at its points of connection to the connector ( 5 ), so that when the septum ( 13 ) is pierced by pressure on the chamber ( 2 ) the latter tears at the frangible points.  
     
     
         8 . Closure cap ( 3 ) for containers ( 4 ) for propellant-free metering aerosols in which a device ( 5 ) is provided which displaces some of the contents of the container whilst it is being pushed onto the neck of a container, characterised in that the device (connector) ( 5 ) contains at least one chamber ( 2 ) which is sealed off from the outside and from the interior of the container ( 4 ) by two pierceable partitions ( 13 ) and ( 14 ).  
     
     
         9 . Closure cap according to  claim 8 , characterised in that the chamber ( 2 ) contains an active substance suitable for administration by inhalation.  
     
     
         10 . Closure cap according to  claim 8  or  9 , characterised in that the active substance is present in the form of a tablet.  
     
     
         11 . Closure cap according to one of the preceding claims, characterised in that the partition separating the chamber ( 2 ) from the outside is in the form of a septum ( 13 ) and the partition from the internal container is constructed as a sealing film ( 14 ).  
     
     
         12 . Closure cap according to one of  claims 8  to  10 , characterised in that the chamber ( 2 ) has frangible points at its points of connection to the connector ( 5 ), so that when the septum ( 13 ) is pierced by pressure on the chamber ( 2 ) the latter tears at the frangible points.  
     
     
         13 . Closure cap according to one of the preceding claims, characterised in that the septum is made from a resilient material so that, even after the interior of the container has been pierced by the cannula, it is sealed off from the outside.  
     
     
         14 . Minitablet as an active substance carrier for propellant-free metering aerosols, containing an active substance for administration by inhalation and optionally pharmacologically acceptable excipients.  
     
     
         15 . Minitablet according to  claim 13 , characterised in that it is between 2 and 3 mm in diameter and between 1.0 and 4.0 mm long.  
     
     
         16 . Minitablet according to one of claims  13  and  14 , characterised in that it has a hardness of between 2 and 10 N/mm 2 .  
     
     
         17 . Minitablet according to one of  claims 13  to  15  for preparing a solution of active substance.