Device for closure of a vascular defect and method of treating the same

Abstract

A device for the non-invasive treatment of a vascular defect. The device includes at least one occlusive member having a first unexpanded configuration and a second expanded configuration and at least one securement member for securing the vaso-occlusive device to a support structure at the location of the vascular defect.

1 . A device for the treatment of a vascular defect, said device comprising: 
 at least one occlusive member having a first unexpanded configuration and a second expanded configuration; and    at least one securement member for securing said device to a support structure at the location of the vascular defect.    
     
     
         2 . The device of  claim 1  wherein said support structure is a stent or stent/graft.  
     
     
         3 . The device of  claim 2  wherein said support structure is a stent of the self-expanding variety.  
     
     
         4 . The device of  claim 1  wherein said at least one securement member, said at least one occlusive member, or both, are comprised of a metal or metal alloy.  
     
     
         5 . The device of  claim 4  wherein said metal is a shape memory metal.  
     
     
         6 . The device of  claim 1  wherein said at least one occlusive member, said at least one securement member, or both, are formed from a polymeric material.  
     
     
         7 . The device of  claim 1  wherein said at least one occlusive member, at least one securement member, or both, are formed from a biologically derived material.  
     
     
         8 . The device of  claim 1  wherein said occlusive member is formed from a biologically derived material.  
     
     
         9 . The device of  claim 8  wherein said biologically derived material is selected from the group consisting of collagen foams, harvested vascular material, processed tissues and combinations thereof.  
     
     
         10 . The device of  claim 1  wherein said at least one occlusive member is formed from a combination of at least one polymeric material and at least one metal or metal alloy.  
     
     
         11 . The device of  claim 10  wherein said at least one occlusive member is in the form of an umbrella, parabola, sphere or disc.  
     
     
         12 . The device of  claim 6  wherein said polymeric material is selected from the group consisting of polyurethanes, polyolefins, polyesters, polyamides, fluoropolymers, silicones, acrylics, polypeptides, and mixtures thereof.  
     
     
         13 . The device of  claim 6  wherein said polymeric material is a swellable polymeric material.  
     
     
         14 . The device of  claim 13  wherein said swellable polymeric material is a hydrogel.  
     
     
         15 . The device of  claim 1  wherein said at least one securement member and at least one occlusive member are formed from a swellable polymeric material.  
     
     
         16 . The device of  claim 1  wherein said at least one securement member swells in an aqueous environment.  
     
     
         17 . The device of  claim 16  wherein said at least one securement member is formed from a hydrogel.  
     
     
         18 . The device of  claim 1  wherein said at least one occlusive member and said at least one securement member are formed from a swellable polymeric material or a compressed foam.  
     
     
         19 . The device of  claim 1  wherein at least a portion of said at least one occlusive member has a braided, woven, knit, felt-like or mesh configuration.  
     
     
         20 . The device of  claim 1  wherein said at least one occlusive member blocks the flow of fluid to a defect in the vasculature.  
     
     
         21 . The device of  claim 1  wherein said vascular defect is an arterial-venus fistula.  
     
     
         22 . The device of  claim 1  wherein said vascular defect is an aneurysm.  
     
     
         23 . The device of  claim 1  further in combination with a catheter.  
     
     
         24 . The device of  claim 1  further comprising at least one radiopaque material.  
     
     
         25 . The device of  claim 1  further comprising at least one bioactive material.  
     
     
         26 . A vaso-occlusive device formed from a swellable material or a compressed foam, said vaso-occlusive device having at least one securement member.  
     
     
         27 . The vaso-occlusive device of  claim 26  wherein said at least one occlusive member of said vaso-occlusive device is in the shape of an umbrella, parabola, sphere or disc.  
     
     
         28 . A method of occluding a vascular defect having an opening, the method comprising the steps of: 
 a) deploying a support structure to said vascular defect said support structure having an opening for accepting a vaso-occlusive device;    b) deploying a vaso-occlusive device having at least one occlusive member having an expanded configuration and an unexpanded configuration and at least one securement member through said opening of said support structure and through said opening of said vascular defect into said vascular defect; and    c) expanding said at least one occlusive member; and    d) anchoring said vaso-occlusive device to said support structure with said at least one securement member.    
     
     
         29 . The method of  claim 28  wherein said support structure is a stent or stent/graft having a plurality of struts.  
     
     
         30 . The method of  claim 28  wherein said support structure is a straight or a bifurcated stent.  
     
     
         31 . The method of  claim 30  wherein said support structure is a stent and said opening for accepting said vaso-occlusive device is formed between said struts.  
     
     
         32 . The method of  claim 30  wherein said support structure is a stent of the self-expanding variety.  
     
     
         33 . The method of  claim 28  wherein said at least one occlusive member is polymeric.  
     
     
         34 . The method of  claim 28  wherein said at least one securement member is metallic or polymeric.  
     
     
         35 . The method of  claim 34  wherein said at least one securement member is formed from more than one strut-like element.  
     
     
         36 . The method of  claim 34  wherein said at least one securement member is formed from a shape memory material or superelastic material.  
     
     
         37 . The method of  claim 34  wherein said at least one securement member is a swellable polymeric material.  
     
     
         38 . The method of  claim 37  wherein said at least one securement member is a hydrogel.  
     
     
         39 . The method of  claim 28  wherein said vaso-occlusive device is deployed with a microcatheter.  
     
     
         40 . A method of closing and occluding an opening of an aneurysm from a parent blood vessel, the method comprising the steps of: 
 a) deploying a support structure at the site of the aneurysm said support structure having at least one opening for accepting a vaso-occlusive device, said vaso-occlusive device having at least one occlusive member which has an unexpanded configuration and an expanded configuration and at least one securement member, said support structure positioned at said opening of said aneurysm such that said at least one opening of said support structure is aligned with said opening of said aneurysm;    b) deploying said vaso-occlusive device wherein said at least one occlusive member is in its unexpanded configuration, through said at least one opening of said support structure and said opening of said aneurysm and into said aneurysm;    c) expanding said at least one occlusive member of said vaso-occlusive device to its expanded state whereby said vaso-occlusive device blocks said opening of said aneurysm from said parent blood vessel in its expanded state; and    d) anchoring said vaso-occlusive device to said support structure with said at least one securement member.    
     
     
         41 . The method of  claim 40  wherein said support structure is a stent having a plurality of struts and said at least one opening is formed between said struts.  
     
     
         42 . The method of  claim 40  wherein said stent is a self-expanding stent.  
     
     
         43 . The method of  claim 40  wherein said vaso-occlusive device is deployed with a microcatheter.  
     
     
         44 . In combination, a vaso-occlusive device having at least one securement member and a stent, the at least one securement member secured to the stent.