Multilaminate backing construction

Abstract

A novel backing construction for a transdermal drug delivery system is disclosed. In particular, the invention relates to a system and method for labeling a transdermal drug delivery system, wherein the backing layer contains a writable medium capable of inkless printing.

1 . A multilaminate backing construction comprising: 
 (a) an outer layer comprising an embossable and writable material;    (b) a tie layer, the tie layer disposed on the skin proximal surface of the outer layer; and    (c) a base layer disposed on the skin proximal surface of the tie layer.    
     
     
         2 . The multilaminate backing construction of  claim 1  wherein the outer layer comprises a breathable material.  
     
     
         3 . The multilaminate backing construction of  claim 2  wherein the outer layer comprises a breathable material comprising, porous, microporous, microfibrullar, spun-bonded, spun laced, track etched, rayon, wood-pulp, spun laced polyester, or coated paper products and combinations thereof.  
     
     
         4 . The multilaminate backing construction of  claim 3  wherein the outer layer comprises a material selected from the group consisting of low density polyethylene (LDPE), medium density polyethylene (MDPE), high density polyethylene (HDPE), ultra high density polyethylene (UHDPE), polypropylene, polyester, and polyethylene.  
     
     
         5 . The multilaminate backing construction of  claim 1  the tie layer comprises a hydrophobic, a lipophilic or a non-polar polymeric material and combinations thereof.  
     
     
         6 . The multilaminate backing construction of  claim 5  wherein the tie layer comprises ethyleneoctene copolymers, ethylene-vinyl acetate copolymer (EVA), low density polyethylene (LDPE), medium density polyethylene (MDPE), non pressures sensitive formulation of styrenic block copolymer or thermoplastic elastomers, and combinations thereof.  
     
     
         7 . A multilaminate backing construction comprising: 
 (a) an outer layer comprising an embossable and writable material, wherein the outer layer is a microporous layer or a microfibrullar layer;    (b) a tie layer comprising a secondary drug-containing reservoir, the tie layer disposed on the skin proximal surface of the outer layer; and    (c) a base layer disposed on the skin proximal surface of the tie layer.    
     
     
         8 . A multilaminate backing construction comprising: 
 (a) an outer layer comprising an embossable and writable material, wherein the outer layer is a microporous layer or a microfibrullar layer;    (b) a tie layer comprising an antagonist-containing reservoir, wherein the antagonist-containing reservoir is disposed on the skin proximal surface of the outer layer; and    (c) a base layer disposed on the skin proximal surface of the tie layer.    
     
     
         9 . The multilaminate backing construction of  claim 8  wherein the antagonist is in a form that is not releasable through the base layer and the outer layer is an antagonist release rate controlling means.  
     
     
         10 . The multilaminate backing construction of  claim 9  wherein the outer layer is coated with surfactants.  
     
     
         11 . The multilaminate backing construction of  claim 8  wherein the base layer is impermeable to the antagonist within the antagonist-containing reservoir.  
     
     
         12 . A multilaminate backing construction comprising: 
 (a) an outer layer comprising an embossable and writable material, wherein the outer layer is a microporous layer or a microfibrullar layer;    (b) a tie layer comprising a secondary drug-containing reservoir, the reservoir comprising a beneficial agent, the secondary drug-containing reservoir being disposed on the skin proximal surface of the outer layer; and    (c) a base layer disposed on the skin proximal surface of the tie layer, wherein the base layer is a drug release rate controlling means.    
     
     
         13 . A multilaminate backing construction comprising: 
 (a) an outer layer comprising an embossable and writable material, wherein the outer layer is a microporous layer or a microfibrullar layer;    (b) a multilaminate tie layer, the tie layer disposed on the skin proximal surface of the outer layer; and    (c) a base layer disposed on the skin proximal surface of the tie layer.    
     
     
         14 . The multilaminate backing construction of  claim 13  wherein the tie layer comprises a secondary drug-containing reservoir.  
     
     
         15 . The multilaminate backing construction of  claim 13  wherein the multilaminate tie layer comprises: 
 (i) a first layer disposed on the skin proximal surface of the outer layer;  
 (ii) a second layer disposed on the skin proximal surface of the first layer;  
 (iii) a third layer disposed on the skin proximal surface of the second layer; and  
 (iv) a secondary drug-containing reservoir.  
 
     
     
         16 . The multilaminate backing construction of  claim 15  wherein the first layer is ethylene-vinyl acetate copolymer (EVA) or low density polyethylene (LDPE) layer; the second layer is a polyethylene terephthalate (PET) layer; the third layer is ethylene-vinyl acetate copolymer (EVA); low density polyethylene (LDPE) layer, or a polyurethane layer.  
     
     
         17 . The multilaminate backing construction of  claim 14  or  claim 15  wherein the secondary drug-containing reservoir comprises a beneficial agent and the base layer is a drug release rate controlling means.