Composition containing oxidation-sensitive hydrophilic active principle and maleic anhydride copolymer, and use thereof

Abstract

The invention relates to the use of a composition, especially for preventing and/or treating cutaneous signs of intrinsic ageing, the composition containing at least one oxidation-sensitive hydrophilic active principle selected from the group consisting of ascorbic acid and its compounds and at least one maleic anhydride copolymer.

1 . A method for preventing and/or treating cutaneous signs of intrinsic ageing, comprising applying to skin a composition comprising at least one oxidation-sensitive hydrophilic active principle selected from the group consisting of ascorbic acid and its compounds and at least one maleic anhydride copolymer comprising one or more maleic anhydride comonomer units and one or more comonomer units selected from the group consisting of vinyl acetate, vinyl alcohol, vinylpyrrolidone, olefins comprising from 2 to 20 carbon atoms, and styrene, in a physiologically acceptable medium comprising an aqueous phase.  
     
     
         2 . The method according to  claim 1 , wherein said method is a method of treating cutaneous signs of intrinsic ageing comprising applying said composition to skin in need thereof.  
     
     
         3 . The method according to  claim 1 , wherein said method is a method of preventing cutaneous signs of intrinsic ageing comprising applying said composition to skin in need thereof.  
     
     
         4 . The method according to  claim 1 , wherein the hydrophilic active principle is selected from the group consisting of 5,6-di-O-dimethylsilylascorbate, the dl-α-tocopheryl dl-ascorbyl phosphate potassium salt of ascorbic acid, magnesium ascorbyl phosphate, sodium ascorbyl phosphate and ascorbyl glucoside.  
     
     
         5 . The method according to  claim 1 , wherein the oxidation-sensitive hydrophilic active principle is ascorbic acid.  
     
     
         6 . The method according to  claim 1 , wherein the maleic anhydride units of the copolymer are in the hydrolysed form and in the form of alkaline salts.  
     
     
         7 . The method according to  claim 1 , wherein the oxidation-sensitive active principle and the copolymer are both in the aqueous phase.  
     
     
         8 . The method according to  claim 1 , wherein the copolymer has a molar fraction of maleic anhydride units of between 0.1 and 1.  
     
     
         9 . The method according to  claim 8 , wherein the copolymer has a molar fraction of maleic anhydride units of between 0.4 and 0.9.  
     
     
         10 . The method according to  claim 1 , wherein the copolymer is a copolymer of styrene and of maleic anhydride in a 50/50 ratio.  
     
     
         11 . The method according to  claim 1 , wherein the copolymer is a copolymer of styrene and of maleic anhydride in a 50/50 ratio in the form of an ammonium or sodium salt.  
     
     
         12 . The method according to  claim 1 , wherein the molar ratio of the maleic anhydride unit equivalent to the oxidation-sensitive hydrophilic active principle varies between 0.005 and 10.  
     
     
         13 . The method according to  claim 1 , wherein the molar ratio of the maleic anhydride unit equivalent to the oxidation-sensitive hydrophilic active principle varies between 0.01 and 1.  
     
     
         14 . The method according to  claim 1 , wherein the copolymer is present at a concentration of between 0.1 and 40% by weight of the aqueous phase.  
     
     
         15 . The method according to  claim 1 , wherein the copolymer is present at a concentration of between 0.1 and 10% by weight of the aqueous phase.  
     
     
         16 . The method according to  claim 1 , wherein the composition further comprises at least one non-ascorboc acid active principle which stimulates dermal macromolecules or which prevents their decomposition and/or an agent which stimulates the proliferation of fibroblasts or keratinocytes and/or the differentiation of keratinocytes.  
     
     
         17 . A method for preventing and/or treating cutaneous signs of intrinsic ageing, comprising applying to skin or mucous membranes a composition comprising at least one oxidation-sensitive hydrophilic active principle selected from the group consisting of ascorbic acid and its compounds and at least one maleic anhydride copolymer comprising one or more maleic anhydride comonomer units and one or more comonomer units selected from the group consisting of vinyl acetate, vinyl alcohol, vinylpyrrolidone, olefins comprising from 2 to 20 carbon atoms, and styrene, in a physiologically acceptable medium comprising an aqueous phase.