Method and composition for the treatment of epidermal irritations and infections

Abstract

An improved stannous fluoride composition is disclosed. The composition comprises stannous fluoride and at least one zinc containing compound. The zinc containing compounds stabilized and prevent hydrolysis of the stannous ions resulting in a more effective stannous fluoride composition for use in the treatment of epidermal irritations and infections.

I claim:  
     
         1 . A composition comprising stannous fluoride and at least one zinc containing compound.  
     
     
         2 . A composition according to  claim 1  wherein the zinc containing compound is a zinc carboxylate.  
     
     
         3 . A composition according to  claim 2  wherein the zinc carboxylate is selected from the group consisting of zinc gluconate, zinc tartrate, zinc malate, zinc citrate and zinc acetate.  
     
     
         4 . A composition according to  claim 2  wherein the zinc carboxylate is zinc gluconate.  
     
     
         5 . A composition according to  claim 2  wherein the zinc containing compound further includes a zinc salt.  
     
     
         6 . A composition according to  claim 5  wherein the zinc salt is selected from the group consisting of zinc chloride, zinc sulfate, zinc phosphate, zinc oxide, zinc pyrophosphate and zinc thiocynate.  
     
     
         7 . A composition according to  claim 5  wherein the zinc salt is zinc chloride.  
     
     
         8 . A composition according to  claim 1  comprising stannous fluoride and zinc gluconate in a non-aqueous medium.  
     
     
         9 . A composition according to  claim 1  further comprising at least one amino acid.  
     
     
         10 . A composition according to  claim 9  wherein the amino acid is an essential or non-essential L or D amino acids from the group consisting of lysine, arginine, histidine, phenylalanine, threonine, leucine, isoluceine, cysteine, methionine, valine, alanine, glycine, proline, glutamine, serine, tryptophan, tyrosine, and asparagine.  
     
     
         11 . A composition according to  claim 1  wherein the stannous fluoride is in an amount from about 0.01% to about 10.0% by weight.  
     
     
         12 . A composition according to  claim 2  wherein the zinc carboxylate is in an amount from about 0.05% to about 10.0% by weight.  
     
     
         13 . A composition according to  claim 5  wherein zinc salt is in an amount from about 0.05% to about 10.0% by weight.  
     
     
         14 . A composition according to  claim 9  wherein the amino acid is in an amount of from about 0.05% to about 50.0% by weight.  
     
     
         15 . A composition according to  claim 9  wherein the amino acid is L-Lysine.  
     
     
         16 . A composition according to  claim 1  comprising:  
       
         
           
                 
                 
                 
               
                     
                     
                 
                     
                     
                 
                     
                   Stannous fluoride 
                    0.20% by wt; 
                 
                     
                   Zinc gluconate 
                    1.50% by wt; and 
                 
                     
                   Glycerin 
                   98.30% by wt. 
                 
                     
                     
                 
                     
                     
                 
             
                
                
               
               
                
                
                
                
                
               
            
           
         
       
     
     
         17 . A composition according to  claim 5  comprising:  
       
         
           
                 
                 
                 
               
                     
                     
                 
                     
                     
                 
                     
                   Stannous fluoride 
                    0.20 % by wt; 
                 
                     
                   Zinc gluconate 
                    1.50% by wt; 
                 
                     
                   Zinc chloride 
                    0.50% by wt; 
                 
                     
                   Glycerin 
                   85.50% by xvt; and 
                 
                     
                   Carbopol 
                    7.30% by wt. 
                 
                     
                     
                 
                     
                     
                 
             
                
                
               
               
                
                
                
                
                
                
                
               
            
           
         
       
     
     
         18 . A composition according to  claim 5  comprising:  
       
         
           
                 
                 
                 
               
                     
                     
                 
                     
                     
                 
                     
                   Stannous fluoride 
                    0.20% by wt; 
                 
                     
                   Zinc gluconate 
                    1.50% by wt; 
                 
                     
                   Zinc chloride 
                    0.50% by wt; 
                 
                     
                   L-Lysine 
                   10.00% by wt; 
                 
                     
                   Glycerine 
                   60.00% by wt; 
                 
                     
                   Carbopol 
                    2.00% by wt; and 
                 
                     
                   Distilled Water 
                   24.80% by wt. 
                 
                     
                     
                 
                     
                     
                 
             
                
                
               
               
                
                
                
                
                
                
                
                
                
               
            
           
         
       
     
     
         19 . A method of treating an epidermal irritation or infection comprising administering an effective amount of a composition comprising stannous fluoride and at least one zinc containing compound to an animal in need thereof.  
     
     
         20 . A method according to  claim 19  wherein the infection is a viral, bacterial, parasitic or fungal infection.  
     
     
         21 . A method according to  claim 20  wherein the viral infection is a herpes infection.  
     
     
         22 . A method according to  claim 20  wherein the viral infection is papilloma virus.  
     
     
         23 . A method according to  claim 20  wherein the fungal infection is caused by the genera Microsporum or Trichophyton.  
     
     
         24 . A method according to  claim 20  wherein the bacterial infection is a caused by Staphylococcus bacterial, Streptococcus or Dermatophilis.  
     
     
         25 . A method according to  claim 19  wherein the epidermal irritation is a burn.  
     
     
         26 . A method according to  claim 20  wherein the animal is a human.  
     
     
         27 . A method according to  claim 20  wherein the animal is a horse, cat or dog.