US2004038980A1PendingUtilityA1
Imidazo-heterobicycles as factor xa inhibitors

Priority: Dec 23, 1998Filed: Aug 15, 2003Published: Feb 26, 2004
Est. expiryDec 23, 2018(expired)· nominal 20-yr term from priority
Inventors:Patrick Lam Charles G. Clark Qi Han Thomas E. Richardson
C07D 487/04C07D 471/04
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Claims
Abstract

The present application describes imidazo-heterobicycles of formulas I and III: or pharmaceutically acceptable salt or prodrug forms thereof. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
Claims

exact text as granted — not AI-modified
What is claimed is:  
     
         1 . A compound of formula I:  
       
         
           
           
               
               
           
         
       
       or a stereoisomer or pharmaceutically acceptable salt thereof, wherein; 
 G is a group of formula IIa or IIb:  
                     
 ring D, including the two atoms of Ring E to which it is attached, is a 5-6 membered non-aromatic ring consisting of carbon atoms, 0-1 double bonds, and from 0-2 N, and D is substituted with 0-2 R, provided that when ring D is unsubstituted, it contains at least one heteroatom;  
 alternatively, ring D, including the two atoms of Ring E to which it is attached, is a 5-6 membered aromatic system consisting of carbon atoms and from 0-2 heteroatoms selected from the group consisting of N, O, and S, and D is substituted with 0-2 R, provided that when ring D is unsubstituted, it contains at least one heteroatom;  
 E is selected from phenyl, pyridyl, pyrimidyl, pyrazinyl, and pyridazinyl, and is substituted with 0-1 R;  
 R is selected from F, Cl, Br, I, OH, OCH 3 , OCH 2 CH 3 , OCH(CH 3 ) 2 , OCH 2 CH 2 CH 3 , NH 2 , NH(C 1-3  alkyl), N(C 1-3  alkyl) 2 , C(═NH)NH 2 , CH 2 NH 2 , CH 2 NH(C 1-3  alkyl), CH 2 N(C 1-3  alkyl) 2 , CH 2 CH 2 NH 2 , CH 2 CH 2 NH(C 1-3  alkyl), and CH 2 CH 2 N(C 1-3  alkyl) 2 ;  
 alternatively, the bridging portion of ring D is absent, ring E is selected from phenyl, pyridyl, pyrimidyl, pyrazinyl, and pyridazinyl, and ring E is substituted with R a  and R b ;  
 R a  is selected from F, Cl, Br, I, OH, OCH 3 , OCH 2 CH 3 , OCH(CH 3 ) 2 , OCH 2 CH 2 CH 3 , CN, C(═NR 8 )NR 7 R 9 , NHC(═NR 8 )NR 7 R 9 , NR 8 CH(═NR 7 ), C(O)NR 7 R 8 , (CR 8 R 9 ) t NR 7 R 8 , SH, SCH 3 , SCH 2 CH 3 , SCH(CH 3 ) 2 , SCH 2 CH 2 CH 3 , S(O)R 3b , S(O) 2 R 3a , S(O) 2 NR 2 R 2a , and OCF 3 ;  
 R b  is selected from H, F, Cl, Br, I, C 1-4  alkyl, SR 3 , CO 2 R 3 , NO 2 , (CH 2 ) t OR 3 , OCF 3 , CF 3 , C(O)NR 7 R 8 , and (CR 8 R 9 ) t NR 7 R 8 ;  
 alternatively, R a  and R b  combine to form methylenedioxy or ethylenedioxy;  
 A is selected from: 
 C 3-10  carbocycle substituted with 0-2 R 4 , and  
 5-10 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-2 R 4 ;  
 
 B is selected from: 
 H, Y, X-Y, C(═NR 2 )NR 2 R 2a , and NR 2 C(═NR 2 )NR 2 R 2a , provided that Z and B are attached to different atoms on A;  
 
 X is selected from C 1-4  alkylene, —CR 2 (CR 2 R 2b ) (CH 2 ) t —, —C(O)—, —C (═NR 1c )—, —CR 2  (NR 1c R 2 )—, —CR 2  (OR 2 )—, —CR 2 (SR 2 )—, C(O)CR 2 R 2a —, CR 2 R 2a C(O), —S—, —S(O)—, —S(O) 2 —, —SCR 2 R 2a —, —S(O)CR 2 R 2a —, —S(O) 2 CR 2 R 2a —, —CR 2 R 2a S—, —CR 2 R 2a S(O)—, —CR 2 R 2a S(O) 2 —, —S(O) 2 NR 2 —, —NR 2 S(O) 2 —, —NR 2 S(O) 2 CR 2 R 2a —, —CR 2 R 2a S(O) 2 NR 2 —, —NR 2 S(O) 2 NR 2 —, —C(O)NR 2 —, —NR 2 C(O)—, —C(O)NR 2 CR 2 R 2a —, —NR 2 C(O)CR 2 R 2a  —, —CR 2 R 2a C(O)NR 2 —, —CR 2 R 2a NR 2 C(O)—, —NR 2 C(O)O—, —OC(O)NR 2 —, —NR 2 C(O)NR 2 —, —NR 2 —, —NR 2 CR 2 R 2a —, —CR 2 R 2a NR 2 —, O, —CR 2 R 2a O—, and —OCR 2 R 2a —;  
 Y is selected from: 
 CH 2 NR 2 R 2a ; CH 2 CH 2 NR 2 R 2a ;  
 C 3-10  carbocycle substituted with 0-2 R 4a , and,  
 5-10 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-2 R 4a ;  
 
 R 1a  is selected from H, —(CH 2 ) r —R 1b , —CH═CH—R 1b , NCH 2 R 1c , OCH 2 R 1c , SCH 2 R 1c , NH(CH 2 ) 2 (CH 2 ) t Rib, O(CH 2 ) 2 (CH 2 ) t R 1b , S(CH 2 ) 2 (CH 2 ) t Rib, S(O) p (CH 2 ) r R 1d , O(CH 2 ) r R d, NR 3  (CH 2 ) r R 1d , OC(O)NR 3 (CH 2 ) r R 1d , NR 3 C(O)NR 3 (CH 2 )R 1d , NR 3 C(O)O(CH 2 ) r R 1d , and NR 3 C(O) (CH 2 ) r R 1d , provided that R 1a  forms other than an N-halo, N—N, N—S, N—O, or N—CN bond;  
 R 1b  is selected from H, C 1-3  alkyl, F, Cl, Br, I, —CN, —CHO, (CF 2 ) r CF 3 , (CH 2 ) r OR 2 , NR 2 R 2a , C(O)R 2c , OC(O)R 2 , (CF 2 ) r CO 2 R 2a , S(O) p R 2b , NR 2 (CH 2 ) r OR 2 , C(═NR 2c )NR 2 R 2a , NR 2 C(O)R 2b , NR 2 C(O)NHR 2b , NR 2 C(O) 2 R 2a , OC(O)NR 2a R 2b , C(O)NR 2 R 2a , C(O)NR 2  (CH 2 ) r OR 2 , SO 2 NR 2 R 2a , NR 2 SO 2 R 2b , C 3-6  carbocycle substituted with 0-2 R 4a , and 5-10 membered heterocycle consisting of carbon atoms and from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-2 R 4a , provided that Rib forms other than an N-halo, N—N, N—S, N—O, or N—CN bond;  
 R 1c  is selected from H, CH(CH 2 OR 2 ) 2 , C(O)R 2c , C(O)NR 2 R 2a , S(O)R 2b , S(O) 2 R 2b , and SO 2 NR 2 R 2a ;  
 R 1d  is selected from C 3-6  carbocycle substituted with 0-2 R 4a , and 5-10 membered heterocycle consisting of carbon atoms and from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-2 R 4a , provided that R 1d  forms other than an N—N, N—S, or N—O bond;  
 R 2 , at each occurrence, is selected from H, CF 3 , C 1-6  alkyl, benzyl, C 3-6  carbocycle substituted with 0-2 R 4b , a C 3-6  carbocyclic-CH 2 -residue substituted with 0-2 R 4b , and 5-6 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-2 R 4b ;  
 R 2a , at each occurrence, is selected from H, CF 3 , C 1-6  alkyl, benzyl, C 3-6  carbocycle substituted with 0-2 R 4b , and 5-6 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-2 R 4b ;  
 R 2b , at each occurrence, is selected from CF 3 , C 1-4  alkoxy, C 1-6  alkyl, benzyl, C 3-6  carbocycle substituted with 0-2 R 4b , and 5-6 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-2 R 4b ;  
 R 2c , at each occurrence, is selected from CF 3 , OH, C 1-4  alkoxy, C 1-6  alkyl, benzyl, C 3-6  carbocyclic residue substituted with 0-2 R 4b , and 5-6 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-2 R 4b ;  
 alternatively, R 2  and R 2a , together with the atom to which they are attached, combine to form a 5 or 6 membered saturated, partially saturated or unsaturated ring substituted with 0-2 R 4b  and consisting of: 0-1 additional heteroatoms selected from the group consisting of N, O, and S;  
 R 3 , at each occurrence, is selected from H, C 1-4  alkyl, and phenyl;  
 R 3a , at each occurrence, is selected from H, C 1-4  alkyl, benzyl, and phenyl;  
 R 3b , at each occurrence, is selected from H, C 1-4  alkyl, and phenyl;  
 R 3c , at each occurrence, is selected from C 1-4  alkyl, benzyl, and phenyl;  
 R 3d , at each occurrence, is selected from H, C 1-4  alkyl, C 1-4  alkyl-phenyl, and C(═O)R 3c ;  
 R 4 , at each occurrence, is selected from H, ═O, (CH 2 ) r OR 2 , F, Cl, Br, I, C 1-4  alkyl, —CN, NO 2 , (CH 2 ) r NR 2 R 2a , (CH 2 ) r C(O)R 2c , NR 2 C(O)R 2b , C(O)NR 2 R 2a , NR 2 C(O)NR 2 R 2a , C(═NR 2 )NR 2 R 2a , C(═NS(O) 2 R 5 )NR 2 R 2a , NHC(═NR 2 )NR 2 R 2a , C(O)NHC(═NR 2 )NR 2 R 2a , SO 2 NR 2 R 2a , NR 2 SO 2 NR 2 R 2a , NR 2 SO 2 —C 1-4  alkyl, NR 2 SO 2 R 5 , S(O) p R 5 , (CF 2 ) r CF 3 , NCH 2 R 1c , OCH 2 R 1c , SCH 2 R 1c , N(CH 2 ) 2 (CH 2 ) t R 1b , O(CH 2 ) 2 (CH 2 ) t R 1b , and S(CH 2 ) 2 (CH 2 ) t R 1b ;  
 alternatively, one R 4  is a 5-6 membered aromatic heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S;  
 R 4a , at each occurrence, is selected from H, ═O, (CH 2 ) r OR 2 , (CH 2 ) r —F, (CH 2 ) r —Br, (CH 2 ) r —Cl, Cl, Br, F, I, C 1-4  alkyl, s-CN, NO 2 , (CH 2 ) r NR 2 R 2a , (CH 2 ) r C(O)R 2c , NR 2 C(O)R 2b , C(O)NR 2 R 2a , (CH 2 ) r N═CHOR 3 , C(O)NH(CH 2 ) 2 NR 2 R 2a , NR 2 C(O)NR 2 R 2a , C(═NR 2 )NR 2 R 2a , NHC(═NR 2 )NR 2 R 2a , SO 2 NR 2 R 2a , NR 2 SO 2 NR 2 R 2a , NR 2 SO 2 —C 1-4  alkyl, C(O)NHSO 2 —C 1-4  alkyl, NR 2 SO 2 R 5 , S(O) p R 5 , and (CF 2 ) r CF 3 ;  
 alternatively, one R 4a  is phenyl substituted with 0-1 R 5  or a 5-6 membered aromatic heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-1 R 5 ;  
 R 4b , at each occurrence, is selected from H, ═O, (CH 2 ) r OR 3 , F, Cl, Br, I, C 1-4  alkyl, —CN, NO 2 , (CH 2 ) r NR 3 R 3a , (CH 2 ) r C(O)R 3 , (CH 2 ) r C(O)OR 3c , NR 3 C(O)R 3a , C(O)NR 3 R 3a , NR 3 C(O)NR 3 R 3a , C(═NR 3 )NR 3 R 3a , NR 3 C(═NR 3 )NR 3 R 3a , SO 2 NR 3 R 3a , NR 3 SO 2 NR 3 R 3a , NR 3 SO 2 —C 1-4  alkyl, NR 3 SO 2 CF 3 , NR 3 SO 2 -phenyl, S(O) p CF 3 , S(O) p —C 1-4  alkyl, S(O) p -phenyl, and (CF 2 ) r CF 3 ;  
 R 5 , at each occurrence, is selected from H, C 1-6  alkyl, ═O, (CH 2 ) r OR 3 , F, Cl, Br, I, C 1-4  alkyl, —CN, NO 2 , (CH 2 ) r NR 3 R 3a , (CH 2 ) r C(O)R 3 , (CH 2 ) r C(O)OR 3c , NR 3 C(O)R 3a , C(O)NR 3 R 3a , NR 3 C(O)NR 3 R 3a , CH(═NOR 3d ), C(═NR 3 )NR 3 R 3a , NR 3c  (═NR 3 )NR 3 R 3a , SO 2 NR 3 R 3a , NR 3 SO 2 NR 3 R 3a , NR 3 SO 2 —C 1-4  alkyl, NR 3 SO 2 CF 3 , NR 3 SO 2 -phenyl, S(O) p CF 3 , S(O) p —C 1-4  alkyl, S(O) p -phenyl, (CF 2 ) r CF 3 , phenyl substituted with 0-2 R 6 , naphthyl substituted with 0-2 R 6 , and benzyl substituted with 0-2 R 6 ;  
 R 6 , at each occurrence, is selected from H, OH, (CH 2 ) r OR 2 , halo, C 1-4  alkyl, CN, NO 2 , (CH 2 ) r NR 2 R 2a , (CH 2 ) r C(O)R 2b , NR 2 C(O)R 2b , NR 2 C(O)NR 2 R 2a , C (═NH)NH 2 , NHC (═NH)NH 2 , SO 2 NR 2 R 2a , NR 2 SO 2 NR 2 R 2a , and NR 2 SO 2 C 1-4  alkyl;  
 R 7 , at each occurrence, is selected from H, OH, C 1-6  alkyl, C 1-6  alkylcarbonyl, C 1-6  alkoxy, C 1-4  alkoxycarbonyl, (CH 2 ) n -phenyl, C 6-10  aryloxy, C 6-10  aryloxycarbonyl, C 6-10  arylmethylcarbonyl, C 1-4  alkylcarbonyloxy C 1-4  alkoxycarbonyl, C 6-10  arylcarbonyloxy C 1-4  alkoxycarbonyl, C 1-6  alkylaminocarbonyl, phenylaminocarbonyl, and phenyl C 1-4  alkoxycarbonyl;  
 R 8 , at each occurrence, is selected from H, C 1-6  alkyl, and (CH 2 ) n-phenyl;  
 alternatively, R 7  and R 8  combine to form a 5 or 6 membered saturated, ring which contains from 0-1 additional heteroatoms selected from the group consisting of N, O, and S;  
 R 9 , at each occurrence, is selected from H, C 1-6  alkyl, and (CH 2 ) n -phenyl;  
 n, at each occurrence, is selected from 0, 1, 2, and 3;  
 p, at each occurrence, is selected from 0, 1, and 2;  
 r, at each occurrence, is selected from 0, 1, 2, 3, 4, 5, and 6;  
 s, at each occurrence, is selected from 0, 1, and 2; and,  
 t, at each occurrence, is selected from 0, 1, 2, and 3.  
 
     
     
         2 . A compound according to  claim 1 , wherein: 
 G is selected from the group:                                                                                A is selected from one of the following carbocyclic and heterocyclic systems which are substituted with 0-2 R 4 ; 
 phenyl, piperidinyl, piperazinyl, pyridyl, pyrimidyl, furanyl, morpholinyl, thiophenyl, pyrrolyl, pyrrolidinyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyrazolyl, imidazolyl, oxadiazolyl, thiadiazolyl, triazolyl, 1,2,3-oxadiazolyl, 1,2,4-oxadiazolyl, 1,2,5-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,3-thiadiazolyl, 1,2,4-thiadiazolyl, 1,2,5-thiadiazolyl, 1,3,4-thiadiazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,5-triazolyl, 1,3,4-triazolyl, benzofuranyl, benzothiofuranyl, indolyl, benzimidazolyl, benzoxazolyl, benzthiazolyl, indazolyl, benzisoxazolyl, benzisothiazolyl, and isoindazolyl;  
   B is Y or X-Y;    X is selected from C 1-4  alkylene, —C(O)—, —C (═NR)—, —CR 2  (NR 2 R 2a )—, —C(O)CR 2 R 2a —, —CR 2 R 2a C(O), —C(O)NR 2 —, —NR 2 C(O)—, —C(O)NR 2 CR 2 R 2a —, —NR 2 C(O)CR 2 R 2a —, CR 2 R 2a C(O)NR 2 , —CR 2 R 2a NR 2 C(O)—, —NR 2 C(O)NR 2 —, —NR 2 —, NR 2 CR 2 R 2a —, CR 2 R 2a NR 2 —, O, —CR 2 R 2a O—, and —OCR 2 R 2a —;    Y is CH 2 NR 2 R 2a  or CH 2 CH 2 NR 2 R 2a ;    alternatively, Y is selected from one of the following carbocyclic and heterocyclic systems that are substituted with 0-2 R 4a ; 
 cyclopropyl, cyclopentyl, cyclohexyl, phenyl, piperidinyl, piperazinyl, pyridyl, pyrimidyl, furanyl, morpholinyl, thiophenyl, pyrrolyl, pyrrolidinyl, oxazolyl, isoxazolyl, isoxazolinyl, thiazolyl, isothiazolyl, pyrazolyl, imidazolyl, oxadiazolyl, thiadiazolyl, triazolyl, 1,2,3-oxadiazolyl, 1,2,4-oxadiazolyl, 1,2,5-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,3-thiadiazolyl, 1,2,4-thiadiazolyl, 1,2,5-thiadiazolyl, 1,3,4-thiadiazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,5-triazolyl, 1,3,4-triazolyl, benzofuranyl, benzothiofuranyl, indolyl, benzimidazolyl, benzoxazolyl, benzthiazolyl, indazolyl, benzisoxazolyl, benzisothiazolyl, and isoindazolyl;  
   alternatively, Y is selected from the following bicyclic heteroaryl ring systems:                          K is selected from O, S, NH, and N.    
     
     
         3 . A compound according to  claim 2 , wherein: 
 G is selected from the group:                                            
     
     
         4 . A compound according to  claim 3 , wherein: 
 G is selected from:                          
     
     
         5 . A compound according to  claim 4 , wherein: 
 A is selected from phenyl, pyridyl, and pyrimidyl, and is substituted with 0-2 R 4 ; and,    B is selected from phenyl, pyrrolidino, N-pyrrolidino-carbonyl, morpholino, N-morpholino-carbonyl, 1,2,3-triazolyl, imidazolyl, and benzimidazolyl, and is substituted with 0-1 R 4a ;    R 2 , at each occurrence, is selected from H, CH 3 , CH 2 CH 3 , cyclopropylmethyl, cyclobutyl, and cyclopentyl;    R 2a , at each occurrence, is H or CH 3 ;    alternatively, R 2  and R 2a , together with the atom to which they are attached, combine to form pyrrolidine substituted with 0-2 R 4b ;    R 4 , at each occurrence, is selected from OH, (CH 2 ) r OR 2 , halo, C 1-4  alkyl, (CH 2 ) r NR 2 R 2a , and (CF 2 ) r CF 3 ;    R 4a  is selected from C 1-4  alkyl, CF 3 , (CH 2 ) r OR 2 , (CH 2 ) r NR 2 R 2a , S(O) p R 5 , SO 2 NR 2 R 2a , and 1-CF 3 -tetrazol-2-yl;    R 4b , at each occurrence, is selected from H, CH 3 , and OH;    R 5 , at each occurrence, is selected from CF 3 , C 1-6  alkyl, phenyl, and benzyl; and,    r, at each occurrence, is selected from 0, 1, and 2.    
     
     
         6 . A compound according to  claim 5 , wherein: 
 A is selected from the group: phenyl, 2-pyridyl, 3-pyridyl, 2-pyrimidyl, 2-Cl-phenyl, 3-Cl-phenyl, 2-F-phenyl, 3-F-phenyl, 2-methylphenyl, 2-aminophenyl, and 2-methoxyphenyl; and,    B is selected from the group: 2-(aminosulfonyl)phenyl, 2-(methylaminosulfonyl)phenyl, 1-pyrrolidinocarbonyl, 2-(methylsulfonyl)phenyl, 2-(N,N-dimethylaminomethyl)phenyl, 2-(N-pyrrolidinylmethyl)phenyl, 1-methyl-2-imidazolyl, 2-methyl-1-imidazolyl, 2-(dimethylaminomethyl)-1-imidazolyl, 2-(N-(cyclopropylmethyl)aminomethyl)phenyl, 2-(N-(cyclobutyl)aminomethyl)phenyl, 2-(N-(cyclopentyl)aminomethyl)phenyl, and 2-(N-(3-hydroxypyrrolidinyl)methyl)phenyl.    
     
     
         7 . A compound according to  claim 1 , wherein the compound is selected from: 
 1-(4-methoxyphenyl)-6-{2′-[aminomethyl]-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(4-methoxyphenyl)-6-{2′-[(methylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(4-methoxyphenyl)-6-{2′-[(dimethylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(4-methoxyphenyl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(4-methoxyphenyl)-6-{2′-[(N-methyl-N-propylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(4-methoxyphenyl)-6-{2′-[(N-t-butylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-([(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-1,1′-biphenyl-4-yl}-1-(4-methoxyphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-{4-[3-(aminosulfonyl)-4-pyridinyl]phenyl}-1-(4-methoxyphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}phenyl)-1-(4-methoxyphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(4-methoxyphenyl)-6-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(2-hydroxyethyl)amino]methyl]-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(4-methoxyphenyl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}phenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-aminosulfonyl-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-methylsulfonyl-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(4-methoxyphenyl)-6-{2′-[aminomethyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(4-methoxyphenyl)-6-{2′-[(methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(4-methoxyphenyl)-6-{2′-[(dimethylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(4-methoxyphenyl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(4-methoxyphenyl)-6-{2′-[(N-methyl-N-propylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(4-methoxyphenyl)-6-{2′-[(N-t-butylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl]-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-1-(4-methoxyphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-{4-[3-(aminosulfonyl)-4-pyridinyl]-2-fluoro-phenyl}-1-(4-methoxyphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-1-(4-methoxyphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(4-methoxyphenyl)-6-[4-(2-methyl-1H-imidazol-1-yl)-2-fluoro-phenyl]-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(2-hydroxyethyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(4-methoxyphenyl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-aminosulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-methylsulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminomethylphenyl)-6-{2′-[aminomethyl]-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminomethylphenyl)-6-{2′-[(methylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminomethylphenyl)-6-{2′-[(dimethylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminomethylphenyl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminomethylphenyl)-6-{2′-[(N-methyl-N-propylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminomethylphenyl)-6-{2′-[(N-t-butylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-1,1′-biphenyl-4-yl}-1-(3-aminomethylphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-{4-[3-(aminosulfonyl)-4-pyridinyl]phenyl}-1-(3-aminomethylphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}phenyl)-1-(3-aminomethylphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminomethylphenyl)-6-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(2-hydroxyethyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminomethylphenyl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}phenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-aminosulfonyl-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-methylsulfonyl-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminomethylphenyl)-6-{2′-[aminomethyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminomethylphenyl)-6-{2′-[(methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminomethylphenyl)-6-{2′-[(dimethylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminomethylphenyl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminomethylphenyl)-6-{2′-[(N-methyl-N-propylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminomethylphenyl)-6-{2′-[(N-t-butylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-[[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-1-(3-aminomethylphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-{4-[3-(aminosulfonyl)-4-pyridinyl]-2-fluoro-phenyl}-1-(3-aminomethylphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-1-(3-aminomethylphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminomethylphenyl)-6-[4-(2-methyl-1H-imidazol-1-yl)-2-fluoro-phenyl]-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(2-hydroxyethyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminomethylphenyl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-aminosulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-methylsulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[aminomethyl]-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(methylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(dimethylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-methyl-N-propylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-t-butylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-[(2′-[(4-hydroxy-1-piperidinyl)methyl]-1,1′-biphenyl-4-yl}-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-{4-[3-(aminosulfonyl)-4-pyridinyl]phenyl}-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}phenyl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminobenzisoxazol-5′-yl)-6-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(2-hydroxyethyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminobenzisoxazol-5′-yl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}phenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-aminosulfonyl-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-methylsulfonyl-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[aminomethyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(dimethylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-methyl-N-propylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-t-butylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-{4-[3-(aminosulfonyl)-4-pyridinyl]-2-fluoro-phenyl}-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminobenzisoxazol-5′-yl)-6-[4-(2-methyl-1H-imidazol-1-yl)-2-fluoro-phenyl]-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(2-hydroxyethyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminobenzisoxazol-5′-yl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-aminosulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-methylsulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-6,7-dihydro-1H-imidazolo[4,5-c]pyridine;    3-[6,7-dihydro-6-[2′-[aminomethyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[6,7-dihydro-6-[2′-[[methylamino]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[6,7-dihydro-6-[2′-[[dimethylamino]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[6,7-dihydro-6-[2′-[[4-hydroxypiperidin-1-yl]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[6,7-dihydro-6-[2′-[[N-ethyl-N-methylamino]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[6,7-dihydro-6-[2′-[[pyrrolidin-1-yl]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[6,7-dihydro-6-[2′-[[3(R)-hydroxypyrrolidin-1-yl]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[6,7-dihydro-6-[2′-[[3(S)-hydroxypyrrolidin-1-yl]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[6,7-dihydro-6-[2′-[[N-propyl-N-methylamino]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[6,7-dihydro-6-[2′-[[t-butylamino]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[6,7-dihydro-6-{4-[3-(aminosulfonyl)-4-pyridinyl]phenyl}-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[6,7-dihydro-6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}phenyl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[6,7-dihydro-6-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[6,7-dihydro-6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-1,1′-biphenyl-4-yl)    7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[6,7-dihydro-6-(2′-{[(2-hydroxyethyl)amino]methyl}-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[6,7-dihydro-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}phenyl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[6,7-dihydro-6-(2′-aminosulfonyl-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[6,7-dihydro-6-(2′-methylsulfonyl-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[6,7-dihydro-6-[2′-[aminomethyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[6,7-dihydro-6-[2′-[[methylamino]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[6,7-dihydro-6-[2′-[[dimethylamino]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[6,7-dihydro-6-[2′-[[4-hydroxypiperidin-1-yl]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[6,7-dihydro-6-[2′-[[N-ethyl-N-methylamino]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[6,7-dihydro-6-[2′-[[pyrrolidin-1-yl]methyl]-3-fluoro[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin    1-yl]benzamide;    3-[6,7-dihydro-6-[2′-[[3(R)-hydroxypyrrolidin-1-yl]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[6,7-dihydro-6-[2′-[[3(S)-hydroxypyrrolidin-1-yl]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[6,7-dihydro-6-[2′-[[N-propyl-N-methylamino]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[6,7-dihydro-6-[2′-[[t-butylamino]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[6,7-dihydro-6-{4-[3-(aminosulfonyl)-4-pyridinyl]-2-fluoro-phenyl}-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[6,7-dihydro-6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[6,7-dihydro-6-[4-(2-methyl-1H-imidazol-1-yl)-2-fluoro-phenyl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[6,7-dihydro-6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-c]pyridin-lyl]benzamide;    3-[6,7-dihydro-6-(2′-{[(2-hydroxyethyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[6,7-dihydro-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[6,7-dihydro-6-(2′-aminosulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; and,    3-[6,7-dihydro-6-(2′-methylsulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    or a pharmaceutically acceptable salt form thereof.    
     
     
         8 . A compound of formula III:  
       
         
           
           
               
               
           
         
       
       or a stereoisomer or pharmaceutically acceptable salt thereof, wherein; 
 ring M, including M 1  and M 2 , is a 6 or 7 membered carbocycle or 6 or 7 membered heterocycle, consisting of: carbon atoms, and 1-3 heteroatoms selected from O, S(O) p , N, and N-Z 2 ;  
 provided that ring M is other than:  
                     
 ring M is substituted with 0-2 R 3  and 0-2 carbonyl groups, and, comprises: 0-2 double bonds;  
 alternatively, M 1  is C(O), M 2  is N, and the remainder of ring M is S(O) 2 ;  
 M 3  is -A-B;  
 G is a group of formula IIa or IIb:  
                     
 ring D, including the two atoms of Ring E to which it is attached, is a 5-6 membered non-aromatic ring consisting of carbon atoms, 0-1 double bonds, and from 0-2 N, and D is substituted with 0-2 R, provided that when ring D is unsubstituted, it contains at least one heteroatom;  
 alternatively, ring D, including the two atoms of Ring E to which it is attached, is a 5-6 membered aromatic system consisting of carbon atoms and from 0-2 heteroatoms selected from the group consisting of N, O, and S, and D is substituted with 0-2 R, provided that when ring D is unsubstituted, it contains at least one heteroatom;  
 E is selected from phenyl, pyridyl, pyrimidyl, pyrazinyl, and pyridazinyl, and is substituted with 0-1 R;  
 R is selected from F, Cl, Br, I, OH, OCH 3 , OCH 2 CH 3 , OCH(CH 3 ) 2 , OCH 2 CH 2 CH 3 , NH 2 , NH(C 1-3  alkyl), N(C 1-3  alkyl) 2 , C(═NH)NH 2 , CH 2 NH 2 , CH 2 NH(C 1-3  alkyl), CH 2 N(C 1-3  alkyl) 2 , CH 2 CH 2 NH 2 , CH 2 CH 2 NH(C 1-3  alkyl), and CH 2 CH 2 N(C 1-3  alkyl) 2 ;  
 alternatively, the bridging portion of ring D is absent, ring E is selected from phenyl, pyridyl, pyrimidyl, pyrazinyl, and pyridazinyl, and ring E is substituted with R a  and R b ;  
 R a  is selected from F, Cl, Br, I, OH, OCH 3 , OCH 2 CH 3 , OCH(CH 3 ) 2 , OCH 2 CH 2 CH 3 , CN, C(═NR 8 )NR 7 R 9 , NHC(═NR 8 )NR 7 R 9 , NR 8 CH(═NR 7 ), C(O)NR 7 R 8 , (CR 8 R 9 ) t NR 7 R 8 , SH, SCH 3 , SCH 2 CH 3 , SCH(CH 3 ) 2 , SCH 2 CH 2 CH 3 , S(O)R 3b , S(O) 2 R 3a , S(O) 2 NR 2 R 2a , and OCF 3 ;  
 R b  is selected from H, F, Cl, Br, I, C 1-4  alkyl, SR 3 , CO 2 R 3 , NO 2 , (CH 2 ) t OR 3 , OCF 3 , CF 3 , C(O)NR 7 R 8 , and (CR 8 R 9 ) t NR 7 R 8 ;  
 alternatively, R a  and R b  combine to form methylenedioxy or ethylenedioxy;  
 A is selected from: 
 C 3-10  carbocycle substituted with 0-2 R 4 , and  
 5-10 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-2 R 4 ;  
 
 B is selected from: 
 H, Y, X-Y, C(═NR 2 )NR 2 R 2a , and NR 2 C(═NR 2 )NR 2 R 2a , provided that Z and B are attached to different atoms on A;  
 
 X is selected from C 1-4  alkylene, —CR 2 (CR 2 R 2b ) (CH 2 ) t —, —C(O)—, —C(═NR 1c )—, —CR 2 (NR 1c R 2 )—, —CR 2 (OR 2 )—, —CR 2 (SR 2 )—, C(O)CR 2 R 2a —, CR 2 R 2a C(O), —S—, —S(O)—, —S(O) 2 —, —SCR 2 R 2a —, —S(O)CR 2 R 2a —, —S(O) 2 CR 2 R 2a —, —CR 2 R 2a S-, —CR 2 R 2a S(O)—, —CR 2 R 2a S(O) 2 —, —S(O) 2 NR 2 —, —NR 2 S(O) 2 —, —NR 2 S(O) 2 CR 2 R 2a —, —CR 2 R 2a S(O) 2 NR 2 —, —NR 2 S(O) 2 NR 2 —, —C(O)NR 2 —, —NR 2 C(O)—, —C(O)NR 2 CR 2 R 2a —, —NR 2 C(O)CR 2 R 2a —, —CR 2 R 2a C(O)NR 2 —, —CR 2 R 2a NR 2 C(O)—, —NR 2 C(O)O—, —OC(O)NR 2 —, —NR 2 C(O)NR 2 —, —NR 2 —, —NR 2 CR 2 R 2a —, —CR 2 R 2a NR 2 —, O, —CR 2 R 2a O-, and —OCR 2 R 2a —;  
 Y is selected from: 
 CH 2 NR 2 R 2a ; CH 2 CH 2 NR 2 R 2a ;  
 C 3-10  carbocycle substituted with 0-2 R 4a , and,  
 5-10 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-2 R 4a ;  
 
 Z 2  is selected from H, C 1-4  alkyl, phenyl, benzyl, C(O)R 3 , and S(O) p R 3c ;  
 R 1a  is selected from H, —(CH 2 ) r —R 1b , —CH═CH—R 1b , NCH 2 R 1c , OCH 2 R 1c , SCH 2 R 1c , NH(CH 2 ) 2 (CH 2 ) t R 1b , O(CH 2 ) 2 (CH 2 ) t R 1b , S(CH 2 ) 2 (CH 2 ) t R 1b , S(O) p (CH 2 ) r R d , O(CH 2 ) r R 1d , NR 3  (CH 2 ) r R 1d , OC(O)NR 3 (CH 2 ) r R 1d , NR 3 C(O)NR 3 (CH 2 ) r R 1d , NR 3 C(O)O(CH 2 ) r R 1d , and NR 3 C(O) (CH 2 ) r R 1d , provided that R 1a  forms other than an N-halo, N—N, N—S, N—O, or N—CN bond;  
 R 1b  is selected from H, C 1-3  alkyl, F, Cl, Br, I, —CN, —CHO, (CF 2 ) r CF 3 , (CH 2 ) r OR 2 , NR 2 R 2a , C(O)R 2c , OC(O)R 2 , (CF 2 ) r CO 2 R 2a , S(O) p R 2b , NR 2  (CH 2 ) r OR 2 , C(═NR 2c )NR 2 R 2a , NR 2 C(O)R 2b , NR 2 C(O)NHR 2b , NR 2 C(O) 2 R 2a , OC(O)NR 2a R 2b , C(O)NR 2 R 2a , C(O)NR 2 (CH 2 ) r OR 2 , SO 2 NR 2 R 2a , NR 2 SO 2 R 2b , C 3-6  carbocycle substituted with 0-2 R 4a , and 5-10 membered heterocycle consisting of carbon atoms and from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-2 R 4a , provided that R 1b  forms other than an N-halo, N—N, N—S, N—O, or N—CN bond;  
 R 1c  is selected from H, CH(CH 2 OR 2 ) 2 , C(O)R 2c , C(O)NR 2 R 2a , S(O)R 2b , S(O) 2 R 2b , and SO 2 NR 2 R 2a ;  
 R 1d  is selected from C 3-6  carbocycle substituted with 0-2 R 4a , and 5-10 membered heterocycle consisting of carbon atoms and from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-2 R 4a , provided that R 1d  forms other than an N—N, N—S, or N—O bond;  
 R 2 , at each occurrence, is selected from H, CF 3 , C 1-6  alkyl, benzyl, C 3-6  carbocycle substituted with 0-2 R 4b , a C 3-6  carbocyclic-CH 2 -residue substituted with 0-2 R 4b , and 5-6 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-2 R 4b ;  
 R 2a , at each occurrence, is selected from H, CF 3 , C 1-6  alkyl, benzyl, C 3-6  carbocycle substituted with 0-2 R 4b , and 5-6 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-2 R 4b ;  
 R 2b , at each occurrence, is selected from CF 3 , C 1-4  alkoxy, C 1-6  alkyl, benzyl, C 3-6  carbocycle substituted with 0-2 R 4b , and 5-6 membered heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-2 R 4b ;  
 R 2c , at each occurrence, is selected from CF 3 , OH, C 1-4  alkoxy, C 1-6  alkyl, benzyl, C 3-6  carbocyclic residue substituted with 0-2 R 4b , and 5-6 membered heterocyclic system containing from 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-2 R 4b ;  
 alternatively, R 2  and R 2a , together with the atom to which they are attached, combine to form a 5 or 6 membered saturated, partially saturated or unsaturated ring substituted with 0-2 R 4b  and consisting of: 0-1 additional heteroatoms selected from the group consisting of N, O, and S;  
 R 3 , at each occurrence, is selected from H, C 1-4  alkyl, and phenyl;  
 R 3a , at each occurrence, is selected from H, C 1-4  alkyl, benzyl, and phenyl;  
 R 3b , at each occurrence, is selected from H, C 1-4  alkyl, and phenyl;  
 R 3c , at each occurrence, is selected from C 1-4  alkyl, benzyl, and phenyl;  
 R 3d , at each occurrence, is selected from H, C 1-4  alkyl, C 1-4  alkyl-phenyl, and C(═O)R 3c ;  
 R 4 , at each occurrence, is selected from H, ═O, (CH 2 ) r OR 2 , F, Cl, Br, I, C 1-4  alkyl, —CN, NO 2 , (CH 2 ) r NR 2 R 2a , (CH 2 ) r C(O)R 2c , NR 2 C(O)R 2b , C(O)NR 2 R 2a , NR 2 C(O)NR 2 R 2a , C (═NR 2 )NR 2 R 2a , C (═NS(O) 2 R 5 )NR 2 R 2a , NHC (═NR 2 )NR 2 R 2a , C(O)NHC (═NR 2 )NR 2 R 2a , SO 2 NR 2 R 2a , NR 2 SO 2 NR 2 R 2a , NR 2 SO 2 —C 1-4  alkyl, NR 2 SO 2 R 5 , S(O) p R 5 , (CF 2 ) r CF 3 , NCH 2 R 1c , OCH 2 R 1c , SCH 2 R 1c , N(CH 2 ) 2 (CH 2 ) t R 1b , O(CH 2 ) 2 (CH 2 ) t R 1b , and S(CH 2 ) 2 (CH 2 ) t R 1b ;  
 alternatively, one R 4  is a 5-6 membered aromatic heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S;  
 R 4a , at each occurrence, is selected from H, ═O, (CH 2 ) r OR 2 , (CH 2 ) r —F, (CH 2 ) r —Br, (CH 2 ) r —Cl, Cl, Br, F, I, C 1-4  alkyl, s-CN, NO 2 , (CH 2 ) r NR 2 R 2a , (CH 2 ) r C(O)R 2c , NR 2 C(O)R 2b , C(O)NR 2 R 2a , (CH 2 ) r N═CHOR 3 , C(O)NH(CH 2 ) 2 NR 2 R 2a , NR 2 C(O)NR 2 R 2a , C (═NR 2 )NR 2 R 2a , NHC (═NR 2 )NR 2 R 2a , SO 2 NR 2 R 2a , NR 2 SO 2 NR 2 R 2a , NR 2 SO 2 —C 1-4  alkyl, C(O)NHSO 2 —C 1-4  alkyl, NR 2 SO 2 R 5 , S(O) p R 5 , and (CF 2 ) r CF 3 ;  
 alternatively, one R 4a  is phenyl substituted with 0-1 R 5  or a 5-6 membered aromatic heterocycle consisting of: carbon atoms and 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-1 R 5 ;  
 R 4b , at each occurrence, is selected from H, ═O, (CH 2 ) r OR 3 , F, Cl, Br, I, C 1-4  alkyl, —CN, NO 2 , (CH 2 ) r NR 3 R 3a , (CH 2 ) r C(O)R 3 , (CH 2 ) r C(O)OR 3c , NR 3 C(O)R 3a , C(O)NR 3 R 3a , NR 3 C(O)NR 3 R 3a , C(═NR 3 )NR 3 R 3a , NR 3 C(═NR 3 )NR 3 R 3a , SO 2 NR 3 R 3a , NR 3 SO 2 NR 3 R 3a , NR 3 SO 2 —C 1-4  alkyl, NR 3 SO 2 CF 3 , NR 3 SO 2 -phenyl, S(O) p CF 3 , S(O) p —C 1-4  alkyl, S(O) p -phenyl, and (CF 2 ) r CF 3 ;  
 R 5 , at each occurrence, is selected from H, C 1-6  alkyl, ═O, (CH 2 ) r OR 3 , F, Cl, Br, I, C 1-4  alkyl, —CN, NO 2 , (CH 2 ) r NR 3 R 3a , (CH 2 ) r C(O)R 3 , (CH 2 ) r C(O)OR 3c , NR 3 C(O)R 3a , C(O)NR 3 R 3a , NR 3 C(O)NR 3 R 3a , CH(═NOR 3d ), C(═NR 3 )NR 3 R 3a , NR 3 C(═NR 3 )NR 3 R 3a , SO 2 NR 3 R 3a , NR 3 SO 2 NR 3 R 3a , NR 3 SO 2 —C 1-4  alkyl, NR 3 SO 2 CF 3 , NR 3 SO 2 -phenyl, S(O) p CF 3 , S(O) p —C 1-4  alkyl, S(O) p -phenyl, (CF 2 ) r CF 3 , phenyl substituted with 0-2 R 6 , naphthyl substituted with 0-2 R 6 , and benzyl substituted with 0-2 R 6 ;  
 R 6 , at each occurrence, is selected from H, OH, (CH 2 ) r OR 2 , halo, C 1-4  alkyl, CN, NO 2 , (CH 2 ) r NR 2 R 2a ,(CH 2 ) r C(O)R 2b , NR 2 C(O)R 2b , NR 2 C(O)NR 2 R 2a , C(═NH)NH 2 , NHC(═NH)NH 2 , SO 2 NR 2 R 2a , NR 2 SO 2 NR 2 R 2a , and NR 2 SO 2 C 1-4  alkyl;  
 R 7 , at each occurrence, is selected from H, OH, C 1-6  alkyl, C 1-6  alkylcarbonyl, C 1-6  alkoxy, C 1-4  alkoxycarbonyl, (CH 2 ) n -phenyl, C 6-10  aryloxy, C 6-10  aryloxycarbonyl, C 6-10  arylmethylcarbonyl, C 1-4  alkylcarbonyloxy C 1-4  alkoxycarbonyl, C 6-10  arylcarbonyloxy C 1-4  alkoxycarbonyl, C 1-6  alkylaminocarbonyl, phenylaminocarbonyl, and phenyl C 1-4  alkoxycarbonyl;  
 R 8 , at each occurrence, is selected from H, C 1-6  alkyl, and (CH 2 ) n -phenyl;  
 alternatively, R 7  and R 8  combine to form a 5 or 6 membered saturated, ring which contains from 0-1 additional heteroatoms selected from the group consisting of N, O, and S;  
 R 9 , at each occurrence, is selected from H, C 1-6  alkyl, and (CH 2 ) n-phenyl;  
 n, at each occurrence, is selected from 0, 1, 2, and 3;  
 p, at each occurrence, is selected from 0, 1, and 2;  
 r, at each occurrence, is selected from 0, 1, 2, 3, 4, 5, and 6;  
 s, at each occurrence, is selected from 0, 1, and 2; and,  
 t, at each occurrence, is selected from 0, 1, 2, and 3.  
 
     
     
         9 . A compound according to  claim 8 , wherein: 
 ring M is substituted with 0-2 R 3  and is selected from the group:                                            Z 2  is selected from H, C 1-4  alkyl, phenyl, benzyl, C(O)R 3 , and S(O) p R 3c ;    G is selected from the group:                                                                                A is selected from one of the following carbocyclic and heterocyclic systems which are substituted with 0-2 R 4 ; 
 phenyl, piperidinyl, piperazinyl, pyridyl, pyrimidyl, furanyl, morpholinyl, thiophenyl, pyrrolyl, pyrrolidinyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyrazolyl, imidazolyl, oxadiazolyl, thiadiazolyl, triazolyl, 1,2,3-oxadiazolyl, 1,2,4-oxadiazolyl, 1,2,5-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,3-thiadiazolyl, 1,2,4-thiadiazolyl, 1,2,5-thiadiazolyl, 1,3,4-thiadiazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,5-triazolyl, 1,3,4-triazolyl, benzofuranyl, benzothiofuranyl, indolyl, benzimidazolyl, benzoxazolyl, benzthiazolyl, indazolyl, benzisoxazolyl, benzisothiazolyl, and isoindazolyl;  
   B is Y or X-Y;    X is selected from C 1-4  alkylene, —C(O)—, —C (═NR)—, —CR 2 (NR 2 R 2a )-, —C(O)CR 2 R 2a —, —CR 2 R 2a C(O), —C(O)NR 2 —, —NR 2 C(O)—, —C(O)NR 2 CR 2 R 2a —, —NR 2 C(O)CR 2 R 2a —, —CR 2 R 2a C(O)NR 2 —, —CR 2 R 2a NR 2 C(O)—, —NR 2 C(O)NR 2 —, —NR 2 —, NR 2 CR 2 R 2a —, CR 2 R 2a NR 2 —, O, —CR 2 R 2a O—, and —OCR 2 R 2a ;    Y is CH 2 NR 2 R 2a  or CH 2 CH 2 NR 2 R 2a ;    alternatively, Y is selected from one of the following carbocyclic and heterocyclic systems that are substituted with 0-2 R 4a ; 
 cyclopropyl, cyclopentyl, cyclohexyl, phenyl, piperidinyl, piperazinyl, pyridyl, pyrimidyl, furanyl, morpholinyl, thiophenyl, pyrrolyl, pyrrolidinyl, oxazolyl, isoxazolyl, isoxazolinyl, thiazolyl, isothiazolyl, pyrazolyl, imidazolyl, oxadiazolyl, thiadiazolyl, triazolyl, 1,2,3-oxadiazolyl, 1,2,4-oxadiazolyl, 1,2,5-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,3-thiadiazolyl, 1,2,4-thiadiazolyl, 1,2,5-thiadiazolyl, 1,3,4-thiadiazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,5-triazolyl, 1,3,4-triazolyl, benzofuranyl, benzothiofuranyl, indolyl, benzimidazolyl, benzoxazolyl, benzthiazolyl, indazolyl, benzisoxazolyl, benzisothiazolyl, and isoindazolyl;  
   alternatively, Y is selected from the following bicyclic heteroaryl ring systems:                          K is selected from O, S, NH, and N.    
     
     
         10 . A compound according to  claim 9 , wherein: 
 ring M is substituted with 0-2 R 3  and is selected from the group:                                            G is selected from the group:                                            
     
     
         11 . A compound according to  claim 10 , wherein: 
 ring M is substituted with 0-1 R 3  and is selected from the group:                          G is selected from:                          
     
     
         12 . A compound according to  claim 11 , wherein: 
 A is selected from phenyl, pyridyl, and pyrimidyl, and is substituted with 0-2 R 4 ; and,    B is selected from phenyl, pyrrolidino, N-pyrrolidino-carbonyl, morpholino, N-morpholino-carbonyl, 1,2,3-triazolyl, imidazolyl, and benzimidazolyl, and is substituted with 0-1 R 4a ;    R 2 , at each occurrence, is selected from H, CH 3 , CH 2 CH 3 , cyclopropylmethyl, cyclobutyl, and cyclopentyl;    R 2a , at each occurrence, is H or CH 3 ;    alternatively, R 2  and R 2a , together with the atom to which they are attached, combine to form pyrrolidine substituted with 0-2 R 4b ;    R 4 , at each occurrence, is selected from OH, (CH 2 ) r OR 2 , halo, C 1-4  alkyl, (CH 2 ) r NR 2 R 2a , and (CF 2 ) r CF 3 ;    R 4a  is selected from C 1-4  alkyl, CF 3 , (CH 2 ) r OR 2 , (CH 2 ) r NR 2 R 2a , S(O) p R 5 , SO 2 NR 2 R 2a , and 1-CF 3 -tetrazol-2-yl;    R 4b , at each occurrence, is selected from H, CH 3 , and OH;    R 5 , at each occurrence, is selected from CF 3 , C 1-6  alkyl, phenyl, and benzyl; and,    r, at each occurrence, is selected from 0, 1, and 2.    
     
     
         13 . A compound according to  claim 12 , wherein: 
 A is selected from the group: phenyl, 2-pyridyl, 3-pyridyl, 2-pyrimidyl, 2-Cl-phenyl, 3-Cl-phenyl, 2-F-phenyl, 3-F-phenyl, 2-methylphenyl, 2-aminophenyl, and 2-methoxyphenyl; and,    B is selected from the group: 2-(aminosulfonyl)phenyl, 2-(methylaminosulfonyl)phenyl, 1-pyrrolidinocarbonyl, 2-(methylsulfonyl)phenyl, 2-(N,N-dimethylaminomethyl)phenyl, 2-(N-pyrrolidinylmethyl)phenyl, 1-methyl-2-imidazolyl, 2-methyl-1-imidazolyl, 2-(dimethylaminomethyl)-1-imidazolyl, 2-(N-(cyclopropylmethyl)aminomethyl)phenyl, 2-(N-(cyclobutyl)aminomethyl)phenyl, 2-(cyclopentyl)aminomethyl)phenyl, and 2-(N-(3-hydroxypyrrolidinyl)methyl)phenyl.    
     
     
         14 . A compound according to  claim 8 , wherein the compound is selected from: 
 7-(3-aminomethyl-phenyl)-1-(2′-methanesulfonyl-biphenyl-4-yl)-3-propyl-3,7-dihydro-purine-2,6 dione;    1-(4-methoxyphenyl)-6-{2′-[aminomethyl]-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(4-methoxyphenyl)-6-{2′-[(methylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(4-methoxyphenyl)-6-{2′-[(dimethylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(4-methoxyphenyl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(4-methoxyphenyl)-6-{2′-[(N-methyl-N-propylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(4-methoxyphenyl)-6-{2′-[(N-t-butylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-1,1′-biphenyl-4-yl}-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-{4-[3-(aminosulfonyl)-4-pyridinyl]phenyl}-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(4-methoxyphenyl)-6-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(2-hydroxyethyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(4-methoxyphenyl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-aminosulfonyl-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-methylsulfonyl-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(4-methoxyphenyl)-6-{2′-[aminomethyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(4-methoxyphenyl)-6-{2′-[(methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(4-methoxyphenyl)-6-{2′-[(dimethylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(4-methoxyphenyl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(4-methoxyphenyl)-6-{2′-[(N-methyl-N-propylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro 1H-imidazolo[4,5-c]pyridine;    1-(4-methoxyphenyl)-6-{2′-[(N-t-butylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(2-{[1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl]-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-{4-[3-(aminosulfonyl)-4-pyridinyl]-2-fluoro-phenyl}-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro 1H-imidazolo[4,5-c]pyridine;    1-(4-methoxyphenyl)-6-[4-(2-methyl-1H-imidazol-1-yl)-2-fluoro-phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(2-hydroxyethyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(4-methoxyphenyl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-aminosulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-methylsulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminomethylphenyl)-6-{2′-[aminomethyl]-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminomethylphenyl)-6-{2′-[(methylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminomethylphenyl)-6-{2′-[(dimethylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminomethylphenyl)-6-2′-[(N-ethyl-N-methylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminomethylphenyl)-6-{2′-[(N-methyl-N-propylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminomethylphenyl)-6-{2′-[(N-t-butylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-4,5,6,7-tetrahydro 1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-4,5,6,7-tetrahydro 1H-imidazolo[4,5-c]pyridine;    6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-1,1′-biphenyl-4-yl}-1-(3-aminomethylphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-{4-[3-(aminosulfonyl)-4-pyridinyl]phenyl}-1-(3-aminomethylphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}phenyl)-1-(3-aminomethylphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminomethylphenyl)-6-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-4,5,6,7-tetrahydro 1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(2-hydroxyethyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminomethylphenyl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-aminosulfonyl-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-methylsulfonyl-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminomethylphenyl)-6-{2′-[aminomethyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminomethylphenyl)-6-{2′-[(methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminomethylphenyl)-6-{2′-[(dimethylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminomethylphenyl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminomethylphenyl)-6-{2′-[(N-methyl-N-propylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminomethylphenyl)-6-{2′-[(N-t-butylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl]-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-[(2′-[(4-hydroxy-1-piperidinyl)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-1-(3-aminomethylphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-{4-[3-(aminosulfonyl)-4-pyridinyl]-2-fluoro-phenyl}-1-(3-aminomethylphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl]-2-fluoro-phenyl)-1-(3-aminomethylphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminomethylphenyl)-6-[4-(2-methyl-1H-imidazol-1-yl)-2-fluoro-phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(2-hydroxyethyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminomethylphenyl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-aminosulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-methylsulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[aminomethyl]-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(methylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(dimethylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-methyl-N-propylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-t-butylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-1;1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-1,1′-biphenyl-4-yl}-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-4,5,6,7-tetrahydro 1H-imidazolo[4,5-c]pyridine;    6-{4-[3-(aminosulfonyl)-4-pyridinyl]phenyl}-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}phenyl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-4,5,6,7-tetrahydro 1H-imidazolo[4,5-c]pyridine;    1-(3-aminobenzisoxazol-5′-yl)-6-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(2-hydroxyethyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminobenzisoxazol-5′-yl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-aminosulfonyl-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-methylsulfonyl-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[aminomethyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(dimethylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro 1H-imidazolo[4,5-c]pyridine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-methyl-N-propylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-t-butylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-4,5,6,7-tetrahydro 1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-{4-[3-(aminosulfonyl)-4-pyridinyl]-2-fluoro-phenyl}-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminobenzisoxazol-5′-yl)-6-[4-(2-methyl-1H-imidazol-1-yl)-2-fluoro-phenyl]-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-{[(2-hydroxyethyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    1-(3-aminobenzisoxazol-5′-yl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-aminosulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    6-(2′-methylsulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]pyridine;    3-[4,5,6,7-tetrahydro-6-[2′-[aminomethyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[2′-[[methylamino]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[2′-[[dimethylamino]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[2′-[[4-hydroxypiperidin-1-yl]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[2′-[[N-ethyl-N-methylamino]-methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[2′-[[pyrrolidin-1-yl]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[2′-[[3(R)-hydroxypyrrolidin-1-yl]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[2′-[[3(S)-hydroxypyrrolidin-1-yl]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[2′-[[N-propyl-N-methylamino]-methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[2′-[[t-butylamino]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-{4-[3-(aminosulfonyl)-4-pyridinyl]phenyl}-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}phenyl)-7-oxo-1H-imidazolo[4,5-c]pyridin 1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-(2′-{[(2-hydroxyethyl)amino]methyl}-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}phenyl)-7-oxo-1H-imidazolo[4,5-c]pyridin 1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-(2′-aminosulfonyl-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-(2′-methylsulfonyl-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[2′-[aminomethyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[2′-[[methylamino]methyl]-3-fluoro[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin 1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[2′-[[dimethylamino]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[2′-[[4-hydroxypiperidin-1-yl]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[2′-[[N-ethyl-N-methylamino]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[2′-[[pyrrolidin-1-yl]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[4,5,6,7—tetrahydro-6-[2′-[[3(R)-hydroxypyrrolidin-1-yl]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[2′-[[3(S)-hydroxypyrrolidin-1-yl]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[2′-[[N-propyl-N-methylamino]-methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[2′-[[t-butylamino]methyl]-3-fluoro[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-c]pyridin 1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-{4-[3-(aminosulfonyl)-4-pyridinyl]-2-fluoro-phenyl}-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[4-(2-methyl-1H-imidazol-1-yl)-2-fluoro-phenyl]-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-(2′-{[(2-hydroxyethyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-(2′-aminosulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide; and,    3-[4,5,6,7-tetrahydro-6-(2′-methylsulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-c]pyridin-1-yl]benzamide;    or a pharmaceutically acceptable salt form thereof.    
     
     
         15 . A compound according to  claim 8 , wherein the compound is selected from: 
 1-(4-Methoxyphenyl)-6-{2′-[aminomethyl]-1,1′-biphenyl-4-yl}-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(4-Methoxyphenyl)-6-{2′-[(methylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(4-Methoxyphenyl)-6-{2′-[(dimethylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(4-Methoxyphenyl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(4-Methoxyphenyl)-6-{2′-[(N-methyl-N-propylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(4-Methoxyphenyl)-6-{2′-[(N-t-butylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-{[1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-1,1′-biphenyl-4-yl}-1-(4-methoxyphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-{4-[3-(aminosulfonyl)-4-pyridinyl]phenyl}-1-(4-methoxyphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}phenyl)-1-(4-methoxyphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(4-methoxyphenyl)-6-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-{[(2-hydroxyethyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(4-methoxyphenyl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}phenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-aminosulfonyl-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-methylsulfonyl-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(4-Methoxyphenyl)-6-{2′-[aminomethyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(4-Methoxyphenyl)-6-{2′-[(methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(4-Methoxyphenyl)-6-{2′-[(dimethylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(4-Methoxyphenyl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(4-Methoxyphenyl)-6-2′-[(N-methyl-N-propylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(4-Methoxyphenyl)-6-{2′-[(N-t-butylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-{[1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-1-(4-methoxyphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-{4-[3-(aminosulfonyl)-4-pyridinyl]-2-fluoro-phenyl}-1-(4-methoxyphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-1-(4-methoxyphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(4-methoxyphenyl)-6-[4-(2-methyl-1H-imidazol-1-yl)-2-fluoro-phenyl]-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-{[(2-hydroxyethyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(4-methoxyphenyl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-aminosulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-methylsulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(3-aminomethylphenyl)-6-{2′-[aminomethyl]-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(3-aminomethylphenyl)-6-{2′-[(methylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(3-aminomethylphenyl)-6-{2′-[(dimethylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5 d]pyrimidine;    1-(3-aminomethylphenyl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(3-aminomethylphenyl)-6-{2′-[(N-methyl-N-propylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(3-aminomethylphenyl)-6-{2′-[(N-t-butylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-{[1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-1,1′-biphenyl-4-yl}-1-(3-aminomethylphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-{4-[3-(aminosulfonyl)-4-pyridinyl]phenyl}-1-(3-aminomethylphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}phenyl)-1-(3-aminomethylphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(3-aminomethylphenyl)-6-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-{[(2-hydroxyethyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(3-aminomethylphenyl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}phenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-aminosulfonyl-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-methylsulfonyl-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(3-aminomethylphenyl)-6-{2′-[aminomethyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(3-aminomethylphenyl)-6-{2′-[(methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(3-aminomethylphenyl)-6-{2′-[(dimethylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(3-aminomethylphenyl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(3-aminomethylphenyl)-6-{2′-[(N-methyl-N-propylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(3-aminomethylphenyl)-6-{2′-[(N-t-butylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-{[1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-1-(3-aminomethylphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-{4-[3-(aminosulfonyl)-4-pyridinyl]-2-fluoro-phenyl}-1-(3-aminomethylphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-1-(3-aminomethylphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(3-aminomethylphenyl)-6-[4-(2-methyl-1H-imidazol-1-yl)-2-fluoro-phenyl]-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-{[(2-hydroxyethyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(3-aminomethylphenyl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-aminosulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-methylsulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[aminomethyl]-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(methylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(dimethylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-methyl-N-propylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-t-butylamino)methyl]-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-{[1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-[2′-[(4-hydroxy-1-piperidinyl)methyl]-1,1′-biphenyl-4-yl}-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-{4-[3-(aminosulfonyl)-4-pyridinyl]phenyl}-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}phenyl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(3-aminobenzisoxazol-5′-yl)-6-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-{[(2-hydroxyethyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(3-aminobenzisoxazol-5′-yl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}phenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-aminosulfonyl-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-methylsulfonyl-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[aminomethyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(dimethylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-methyl-N-propylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-t-butylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-{[1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-{4-[3-(aminosulfonyl)-4-pyridinyl]-2-fluoro-phenyl}-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(3-aminobenzisoxazol-5′-yl)-6-[4-(2-methyl-1H-imidazol-1-yl)-2-fluoro-phenyl]-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-{[(2-hydroxyethyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    1-(3-aminobenzisoxazol-5′-yl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-aminosulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-1,6-dihydro-1H-imidazolo[4,5-d]pyrimidine;    6-(2′-methylsulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-7-oxo-1,6-dihydro-1H imidazolo[4,5-d]pyrimidine;    3-[1,6-dihydro-6-[2′-[aminomethyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide;    3-[(1,6-dihydro-6-[2′-[[methylamino]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide;    3-[(1,6-dihydro-6-(2′-[[dimethylamino]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide;    3-[1,6-dihydro-6-[2′-[[4-hydroxypiperidin-1-yl]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide;    3-[1,6-dihydro-6-[2′-[[N-ethyl-N-methylamino]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide;    3-[1,6-dihydro-6-[2′-[[pyrrolidin-1-yl]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide;    3-[1,6-dihydro-6-[2′-[[3(R)-hydroxypyrrolidin-1-yl]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide;    3-[1,6-dihydro-6-[2′-[[3(S)-hydroxypyrrolidin-1-yl]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide;    3-[1,6-dihydro-6-[2′-[[N-propyl-N-methylamino]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide;    3-[1,6-dihydro-6-[2′-[[t-butylamino]methyl][1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide;    3-[1,6-dihydro-6-{4-[3-(aminosulfonyl)-4-pyridinyl]phenyl}-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide;    3-[1,6-dihydro-6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}phenyl)-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide;    3-[1,6-dihydro-6-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide;    3-[1,6-dihydro-6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide;    3-[1,6-dihydro-6-(2′-{[(2-hydroxyethyl)amino]methyl}-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide;    3-[1,6-dihydro-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}phenyl)-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide;    3-[1,6-dihydro-6-(2′-aminosulfonyl-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide;    3-[1,6-dihydro-6-(2′-methylsulfonyl-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide;    3-[1,6-dihydro-6-[2′-[aminomethyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide;    3-[1,6-dihydro-6-[2′-[[methylamino]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide;    3-[1,6-dihydro-6-[2′-[[dimethylamino]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide;    3-[1,6-dihydro-6-[2′-[[4-hydroxypiperidin-1-yl]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide;    3-[1,6-dihydro-6-[2′-[[N-ethyl-N-methylamino]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide;    3-[1,6-dihydro-6-[2′-[[pyrrolidin-1-yl]methyl]-3-fluoro[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide;    3-[1,6-dihydro-6-[2′-[[3(R)-hydroxypyrrolidin-1-yl]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide;    3-[1,6-dihydro-6-[2′-[[3(S)-hydroxypyrrolidin-1-yl]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide;    3-[1,6-dihydro-6-[2′-[[N-propyl-N-methylamino]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide;    3-[1,6-dihydro-6-[2′-[[t-butylamino]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide;    3-[1,6-dihydro-6-{4-[3-(aminosulfonyl)-4-pyridinyl]-2-fluoro-phenyl}-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide;    3-[1,6-dihydro-6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide;    3-[1,6-dihydro-6-[4-(2-methyl-1H-imidazol-1-yl)-2-fluoro-phenyl]-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide;    3-[1,6-dihydro-6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-d]pyrimidin-lyl]benzamide;    3-[1,6-dihydro-6-(2′-{[(2-hydroxyethyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide;    3-[1,6-dihydro-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide;    3-[1,6-dihydro-6-(2′-aminosulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide;    3-[1,6-dihydro-6-(2′-methylsulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-7-oxo-1H-imidazolo[4,5-d]pyrimidin-1-yl]benzamide;    or a pharmaceutically acceptable salt form thereof.    
     
     
         16 . A compound according to  claim 8 , wherein the compound is selected from: 
 1-(4-methoxyphenyl)-6-{2′-[aminomethyl]-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(4-methoxyphenyl)-6-{2′-[(methylamino)methyl]-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(4-methoxyphenyl)-6-{2′-[(dimethylamino)methyl]-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(4-methoxyphenyl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(4-methoxyphenyl)-6-{2′-[(N-methyl-N-propylamino)methyl]-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(4-methoxyphenyl)-6-{2′-[(N-t-butylamino)methyl]-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(2′-{[1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-1,1′-biphenyl-4-yl}-1-(4-methoxyphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-{4-[3-(aminosulfonyl)-4-pyridinyl]phenyl}-1-(4-methoxyphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}phenyl)-1-(4-methoxyphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(4-methoxyphenyl)-6-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(2′-{[(2-hydroxyethyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(4-methoxyphenyl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}phenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(2′-aminosulfonyl-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(2′-methylsulfonyl-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(4-methoxyphenyl)-6-{2′-[aminomethyl]-3-fluoro-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(4-methoxyphenyl)-6-{2′-[(methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(4-methoxyphenyl)-6-{2′-[(dimethylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(4-methoxyphenyl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(4-methoxyphenyl)-6-{2′-[(N-methyl-N-propylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro 1H-imidazolo[4,5-c]azepine;    1-(4-methoxyphenyl)-6-{2′-[(N-t-butylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(2′-{[1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-1-(4-methoxyphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-{4-[3-(aminosulfonyl)-4-pyridinyl]-2-fluoro-phenyl}-1-(4-methoxyphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-1-(4-methoxyphenyl)-8-oxo-4,5,6,7-tetrahydro 1H-imidazolo[4,5-c]azepine;    1-(4-methoxyphenyl)-6-[4-(2-methyl-1H-imidazol-1-yl)-2-fluoro-phenyl]-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(2′-{[(2-hydroxyethyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(4-methoxyphenyl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(2′-aminosulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(2′-methylsulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(4-methoxyphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(3-aminomethylphenyl)-6-{2′-[aminomethyl]-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(3-aminomethylphenyl)-6-{2′-[(methylamino)methyl]-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(3-aminomethylphenyl)-6-{2′-[(dimethylamino)methyl]-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(3-aminomethylphenyl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(3-aminomethylphenyl)-6-{2′-[(N-methyl-N-propylamino)methyl]-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(3-aminomethylphenyl)-6-{2′-[(N-t-butylamino)methyl]-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(2′-{[1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-8-oxo-4,5,6,7-tetrahydro 1H-imidazolo[4,5-c]azepine;    6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-8-oxo-4,5,6,7-tetrahydro 1H-imidazolo[4,5-c]azepine;    6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-1,1′-biphenyl-4-yl}-1-(3-aminomethylphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-{4-[3-(aminosulfonyl)-4-pyridinyl]phenyl}-1-(3-aminomethylphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}phenyl)-1-(3-aminomethylphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(3-aminomethylphenyl)-6-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-8-oxo-4,5,6,7-tetrahydro 1H-imidazolo[4,5-c]azepine;    6-(2′-{[(2-hydroxyethyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(3-aminomethylphenyl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}phenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(2′-aminosulfonyl-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(2′-methylsulfonyl-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(3-aminomethylphenyl)-6-{2′-[aminomethyl]-3-fluoro-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(3-aminomethylphenyl)-6-{2′-[(methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(3-aminomethylphenyl)-6-{2′-[(dimethylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(3-aminomethylphenyl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(3-aminomethylphenyl)-6-{2′-[(N-methyl-N-propylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(3-aminomethylphenyl)-6-{2′-[(N-t-butylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(2′-{[1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-1-(3-aminomethylphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-{4-[3-(aminosulfonyl)-4-pyridinyl]-2-fluoro-phenyl}-1-(3-aminomethylphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-1-(3-aminomethylphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(3-aminomethylphenyl)-6-[4-(2-methyl-1H-imidazol-1-yl)-2-fluoro-phenyl]-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(2′-{[(2-hydroxyethyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(3-aminomethylphenyl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(2′-aminosulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(2′-methylsulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminomethylphenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[aminomethyl]-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(methylamino)methyl]-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(dimethylamino)methyl]-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-methyl-N-propylamino)methyl]-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-t-butylamino)methyl]-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(2′-{[1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-1,1′-biphenyl-4-yl}-1-(3-aminobenzisoxazol-5′-yl)-8-oxo-4,5,6,7-tetrahydro 1H-imidazolo[4,5-c]azepine;    6-{4-[3-(aminosulfonyl)-4-pyridinyl]phenyl}-1-(3-aminobenzisoxazol-5′-yl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}phenyl)-1-(3-aminobenzisoxazol-5′-yl)-8-oxo-4,5,6,7-tetrahydro 1H-imidazolo[4,5-c]azepine;    1-(3-aminobenzisoxazol-5′-yl)-6-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(2′-{[(2-hydroxyethyl)amino]methyl}-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-8-oxo-4,5,6,7-tetrahydro 1H-imidazolo[4,5-c]azepine;    1-(3-aminobenzisoxazol-5′-yl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}phenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(2′-aminosulfonyl-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(2′-methylsulfonyl-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[aminomethyl]-3-fluoro-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(dimethylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro 1H-imidazolo[4,5-c]azepine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-ethyl-N-methylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-methyl-N-propylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(3-aminobenzisoxazol-5′-yl)-6-{2′-[(N-t-butylamino)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(2′-{[1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-8-oxo-4,5,6,7-tetrahydro 1H-imidazolo[4,5-c]azepine;    6-(2′-{[(3S)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(2′-{[(3R)-3-hydroxy-1-pyrrolidinyl]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-{2′-[(4-hydroxy-1-piperidinyl)methyl]-3-fluoro-1,1′-biphenyl-4-yl}-1-(3-aminobenzisoxazol-5′-yl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-{4-[3-(aminosulfonyl)-4-pyridinyl]-2-fluoro-phenyl}-1-(3-aminobenzisoxazol-5′-yl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-1-(3-aminobenzisoxazol-5′-yl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(3-aminobenzisoxazol-5′-yl)-6-[4-(2-methyl-1H-imidazol-1-yl)-2-fluoro-phenyl]-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(2′-{[(2-hydroxyethyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    1-(3-aminobenzisoxazol-5′-yl)-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(2′-aminosulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    6-(2′-methylsulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-1-(3-aminobenzisoxazol-5′-yl)-8-oxo-4,5,6,7-tetrahydro-1H-imidazolo[4,5-c]azepine;    3-[4,5,6,7-tetrahydro-6-[2′-[aminomethyl][1,1′-biphenyl]-4-yl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[2′-[[methylamino]methyl][1,1′-biphenyl]-4-yl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[2′-[[dimethylamino]methyl][1,1′-biphenyl]-4-yl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[2′-[[4-hydroxypiperidin-1-yl]methyl][1,1′-biphenyl]-4-yl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[2′-[[N-ethyl-N-methylamino]-methyl][1,1′-biphenyl]-4-yl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[2′-[[pyrrolidin-1-yl]methyl][1,1′-biphenyl]-4-yl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[2′-[[3(R)-hydroxypyrrolidin-1-yl]methyl][1,1′-biphenyl]-4-yl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[2′-[[3(S)-hydroxypyrrolidin-1-yl]methyl][1,1′-biphenyl]-4-yl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[2′-[[N-propyl-N-methylamino]-methyl][1,1′-biphenyl]-4-yl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[2′-[[t-butylamino]methyl][1,1′-biphenyl]-4-yl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-{4-[3-(aminosulfonyl)-4-pyridinyl]phenyl}-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}phenyl)-8-oxo-1H-imidazolo[4,5-c]azepin 1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-1,1′-biphenyl-4-yl)-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-(2′-{[(2-hydroxyethyl)amino]methyl}-1,1′-biphenyl-4-yl)-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}phenyl)-8-oxo-1H-imidazolo[4,5-c]azepin 1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-(2′-aminosulfonyl-1,1′-biphenyl-4-yl)-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-(2′-methylsulfonyl-1,1′-biphenyl-4-yl)-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[2′-[aminomethyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[2′-[[methylamino]methyl]-3-fluoro[1,1′-biphenyl]-4-yl]-8-oxo-1H-imidazolo[4,5-c]azepin 1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[2′-[[dimethylamino]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[2′-[[4-hydroxypiperidin-1-yl]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[2′-[[N-ethyl-N-methylamino]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[2′-[[pyrrolidin-1-yl]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[2′-[[3(R)-hydroxypyrrolidin-1-yl]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[2′-[[3(S)-hydroxypyrrolidin-1-yl]methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[2′-[[N-propyl-N-methylamino]-methyl]-3-fluoro-[1,1′-biphenyl]-4-yl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[2′-[[t-butylamino]methyl]-3-fluoro[1,1′-biphenyl]-4-yl]-8-oxo-1H-imidazolo[4,5-c]azepin 1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-{4-[3-(aminosulfonyl)-4-pyridinyl]-2-fluoro-phenyl}-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-[4-(2-methyl-1H-imidazol-1-yl)-2-fluoro-phenyl]-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-(2′-{[(2-hydroxyethyl)(methyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-(2′-{[(2-hydroxyethyl)amino]methyl}-3-fluoro-1,1′-biphenyl-4-yl)-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-(4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}-2-fluoro-phenyl)-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-(2′-aminosulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide;    3-[4,5,6,7-tetrahydro-6-(2′-methylsulfonyl-3-fluoro-1,1′-biphenyl-4-yl)-8-oxo-1H-imidazolo[4,5-c]azepin-1-yl]benzamide; or a pharmaceutically acceptable salt form thereof.    
     
     
         17 . A pharmaceutical composition, comprising: a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of  claim 1  or a pharmaceutically acceptable salt form thereof.  
     
     
         18 . A method for treating a thromboembolic disorder, comprising: administering to a patient in need thereof a therapeutically effective amount of a compound of  claim 1  or a pharmaceutically acceptable salt form thereof.
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