Ethanolaminephosphate cytidylyltransferase gene and promoter

Abstract

The invention provides a gene encoding a protein having ethanolaminephosphate cytidylyltransferase activity, and a promoter of an ethanolaminephosphate cytidylyltransferase gene. Nucleotide sequences according to SEQ ID NO: 1 and SEQ ID NO: 2 relate to the gene and the promoter, respectively. An antibody against mECT peptide (SEQ ID NO: 53) is also provided.

1 . A gene encoding a protein having ethanolarninephosphate cytidylyltransferase activity consisting of a sequence selected from the group consisting of: 
 (a) SEQ ID NO: 1;    (b) a degenerate sequence of SEQ ID NO: 1 and    (c) a sequence which hybridizes to the complement of SEQ ID NO: 1 under stringent conditions.    
     
     
         2 . The gene according to  claim 1  consisting of SEQ ID NO: 1.  
     
     
         3 . The gene according to  claim 1  derived from a human or a mouse.  
     
     
         4 . A promoter of an ethanolaminephosphate cytidylyltransferase gene, said promoter consisting of a sequence selected from the group consisting of: 
 (a) SEQ ID NO: 2;    (b) a sequence having at least 90% identity to SEQ ID NO: 2 having substitutions or deletions and maintaining promoter activity; and    (c) a sequence which hybridizes to the complement of SEQ ID NO: 2 under stringent conditions.    
     
     
         5 . The promoter according to  claim 4  consisting of SEQ ID NO: 2.  
     
     
         6 . A CTP:Ethanolaminephosphate Citidylyltransferase (ECT) peptide having the sequence CTKAHHSSQEMSSEYRE according to SEQ ID NO: 53.  
     
     
         7 . A CTP:Ethanolaminephosphate Citidylyltransferase (ECT) specific antibody against the peptide of  claim 6.