Anthelminthic for the prevention of parasitic infections in human and animals

Abstract

The present invention relates to compositions comprising certain active compounds which are suitable as repellents, and to their use for preventing an infection of humans or of animals by the infectious stages of parasitic flatworms (platyhelminths).

1 . Compositions for deterring helmintic parasites, characterized in that they comprise at least one compound of the formula (I)  
       
         
           
           
               
               
           
         
         in which 
 Y represents hydrogen, optionally substituted alkyl or the radical O—X,  
 X represents hydrogen, COR 11 , COOR 12  or R 13 ,  
 R 1  represents an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl or cycloalkenyl radical,  
 R 2 , R 11 , R 12  and R 13  are identical or different and represent optionally substituted alkyl or alkenyl radicals,  
 R 3  to R 10  are identical or different and represent hydrogen or represent optionally substituted alkyl radicals, where R 2  and R 3  or R 3  and R 7  or R 3  and R 5  or R 5  and R 7  together with the atoms to which they are attached may also form an optionally substituted monocyclic ring and  
 n and m are identical or different and are 0 or 1.  
 
       
     
     
         2 . Compositions for deterring helmintic parasites according to  claim 1 , characterized in that they comprise at least one compound of the formula (I) 
 in which 
 Y represents hydrogen, C 1 -C 6 -alkyl or the radical O—X,  
 X represents hydrogen, COR 11  or R 13 ,  
 R 1  represents C 3 -C 7 -cycloalkyl, C 3 -C 7 -cycloalkenyl, C 1 -C 2 -alkyl-C 3 -C 7 -cycloalkyl, C 1 -C 2 -alkyl-C 3 -C 7 -cycloalkenyl, where the cycloalkyl or cycloalkenyl rings of the abovementioned radicals are optionally substituted up to three times by C 1 -C 6 -alkyl or by a C 1 -C 6 -dialkylene bridge, or  
 R 1  represents C 1 -C 7 -alkyl, C 2 -C 7 -alkenyl or C 2 -C 7 -alkinyl,  
 R 2 , R 11 , R 13  are identical or different and represent C-C 6 -alkyl,  
 R 3  to R 8  are identical or different and represent hydrogen or C 1 -C 6 -alkyl, where R 2  and R 3  or R 3  and R 7  or R 3  and R 5  or R 5  and R 7  together with the atoms to which they are attached may also form a 5- or 6-membered monocyclic ring and  
 n represents I and m represents 0.  
   
     
     
         3 . A method for deterring helmintic parasites, characterized in that compounds of the formula (I) according to  claim 1  are applied to the skin of the organism to be protected.  
     
     
         4 . Use of compounds of the formula (I) according to  claim 1  for deterring helmintic parasites.  
     
     
         5 . Process for preparing compositions for deterring helminthic parasites, characterized in that compounds of the formula (I) according to  claim 1  are mixed with extenders and/or surfactants.