Storage solution containing photosensitizer for inactivation of biological contaminants

Abstract

A platelet/additive solution comprising bicarbonate, citrate and glucose. Additionally, a platelet/additive and treatment solution comprising bicarbonate, citrate, glucose and a photosensitizer.

We claim:  
     
         1 . A fluid comprising 
 a collected blood or blood component removed from a donor/patient; and    a decontamination treatment solution wherein the decontamination treatment solution further comprises: 
 a nutrient;  
 an endogenous alloxazine;  
 a buffer; and  
 an anticoagulant  
 wherein the decontamination treatment solution is used in the decontamination treatment of the collected blood or blood components.  
   
     
     
         2 . The fluid of  claim 1  wherein the nutrient comprises glucose.  
     
     
         3 . The fluid of  claim 2  wherein the glucose is in a concentration between 33-52 mM.  
     
     
         4 . The fluid of  claim 1  wherein the buffer comprises a bicarbonate.  
     
     
         5 . The fluid of  claim 4  wherein the bicarbonate is in a concentration between 63-95 mM.  
     
     
         6 . The fluid of  claim 1  wherein the endogenous alloxazine comprises 7,8-dimethyl-10-ribityl isoalloxazine.  
     
     
         7 . The fluid of  claim 6  wherein the 7, 8-dimethyl-10-ribytl isoalloxazine is in a concentration of approximately 8-50 μM.  
     
     
         8 . The fluid of  claim 1  wherein the anticoagulant comprises citrate.  
     
     
         9 . The fluid of  claim 8  wherein the citrate is in a concentration between 5.1-8.8 mM.  
     
     
         10 . A bag containing the fluid of  claim 1 .  
     
     
         11 . A bag containing the fluid of  claim 6 .  
     
     
         12 . The fluid of  claim 1  wherein the collected blood or blood component comprises platelets.  
     
     
         13 . The fluid of  claim 1  wherein the collected blood or blood component comprises platelets with about 40% retained plasma.  
     
     
         14 . The fluid of  claim 1  wherein the decontamination treatment solution is further used for storing the collected blood or blood components after the decontamination treatment.  
     
     
         15 . The fluid of  claim 12  wherein the decontamination treatment solution is further used for storing the platelets after the decontamination treatment.