US2004014692A1PendingUtilityA1

Compositions incorporating(-)-hydroxycitric acid, chromium, and gymnemic acid, and related methods for promoting healthy body weight and improving related health factors

49
Priority: Dec 20, 2001Filed: Dec 20, 2002Published: Jan 22, 2004
Est. expiryDec 20, 2021(expired)· nominal 20-yr term from priority
Inventors:Debasis BagchiHarry Preuss
A61P 3/06A61K 31/704A61K 36/38A61K 31/194A23L 33/105A23V 2002/00A61K 31/19A61K 31/555A61P 3/04A23L 33/165A61K 36/27A61K 33/24
49
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Claims

Abstract

Methods for promoting healthy body weight and improving a variety of related physiological factors, including serum serotonin levels, serum leptin levels, fat oxidation, cholesterol levels, and body mass index, in persons or other mammals, include administering to those persons or other mammals effective amounts of hydroxycitric acid or a combination of hydroxycitric acid, chromium and gymnemic acid, which work synergistically to further to promote healthy body weight and improve these physiological factors.

Claims

exact text as granted — not AI-modified
We claim:  
     
         1 . A composition comprising hydroxycitric acid, chromium, and gymnemic acid.  
     
     
         2 . A composition as defined in  claim 1 , wherein the hydroxycitric acid is bound to calcium and potassium.  
     
     
         3 . A composition as defined in  claim 1 , wherein the composition of hydroxycitric acid comprises hydroxycitric acid is derived from a plant of the genus Garcinia.  
     
     
         4 . A composition as defined in  claim 3 , wherein the plant is  Garcinia cambogia.    
     
     
         5 . A composition as defined in  claim 1 , wherein the chromium comprises niacin-bound chromium.  
     
     
         6 . A composition as defined in  claim 5 , wherein the chromium comprises oxygen-coordinated niacin-bound chromium.  
     
     
         7 . A composition as defined in  claim 1 , wherein the gymnemic acid is derived from a plant of the genus Gymnema.  
     
     
         8 . A composition as defined in  claim 7 , wherein the plant is  Gymnema sylvestre.    
     
     
         9 . A composition as defined in  claim 1 , wherein the composition is in the form of a pill, tablet, capsule, lozenge, gum, liquid, powder, food, beverage or other orally administered form.  
     
     
         10 . A method for increasing serotonin level in a person or other mammal comprising: 
 identifying a person or other mammal that can benefit from increased serotonin level; and    administering to the person or other mammal a composition comprising hydroxycitric acid in an amount sufficient to increase serotonin level in the person or other mammal.    
     
     
         11 . A method as defined in  claim 10 , wherein the composition comprises hydroxycitric acid bound to calcium and potassium.  
     
     
         12 . A method as defined in  claim 10 , wherein the composition comprises hydroxycitric acid is derived from a plant of the genus Garcinia.  
     
     
         13 . A method as defined in  claim 12 , wherein the plant is  Garcinia cambogia.    
     
     
         14 . A method as defined in  claim 10 , wherein the step of administering comprises administering approximately 100 milligrams to approximately 5,000 milligrams of hydroxycitric acid daily.  
     
     
         15 . A method as defined in  claim 14 , wherein the step of administering comprises administering approximately 2,700 milligrams to approximately 2,800 milligrams of hydroxycitric acid daily.  
     
     
         16 . A method as defined in  claim 10 , wherein the step of administering comprises administering the composition daily in three substantially equally divided doses, approximately 30 to 60 minutes before meals.  
     
     
         17 . A method as defined is  claim 10 , wherein the step of administering comprises administering the composition orally.  
     
     
         18 . A method as defined in  claim 10 , wherein the composition further comprises chromium and gymnemic acid.  
     
     
         19 . A method as defined in  claim 18 , wherein the composition comprises niacin-bound chromium.  
     
     
         20 . A method as defined in  claim 19 , wherein the composition comprises oxygen-coordinated niacin-bound chromium.  
     
     
         21 . A method as defined in  claim 18 , wherein the composition comprises gymnemic acid derived from a plant of the genus Gymnema.  
     
     
         22 . A method as defined in  claim 21 , wherein the plant is  Gymnema sylvestre.    
     
     
         23 . A method as defined in  claim 18 , wherein the step of administering comprises administering approximately 10 micrograms to approximately 1,000 micrograms of chromium and approximately 10 milligrams to approximately 1,000 milligrams of gymnemic acid daily.  
     
     
         24 . A method as defined in  claim 23 , wherein the step of administering comprises administering approximately 400 micrograms of chromium and approximately 100 milligrams of gymnemic acid daily.  
     
     
         25 . A method for decreasing leptin level in a person or other mammal comprising: 
 identifying a person or other mammal that can benefit from decreased leptin level; and    administering to the person or other mammal a composition comprising hydroxycitric acid in an amount sufficient to decrease leptin level in the person or other mammal.    
     
     
         26 . A method as defined in  claim 25 , wherein the composition comprises hydroxycitric acid bound to calcium and potassium.  
     
     
         27 . A method as defined in  claim 25 , wherein the composition comprises hydroxycitric acid is derived from a plant of the genus Garcinia.  
     
     
         28 . A method as defined in  claim 27 , wherein the plant is  Garcinia cambogia.    
     
     
         29 . A method as defined in  claim 25 , wherein the step of administering comprises administering approximately 100 milligrams to approximately 5,000 milligrams of hydroxycitric acid daily.  
     
     
         30 . A method as defined in  claim 29 , wherein the step of administering comprises administering approximately 2,700 milligrams to approximately 2,800 milligrams of hydroxycitric acid daily.  
     
     
         31 . A method as defined in  claim 25 , wherein the step of administering comprises administering the composition daily in three substantially equally divided doses, approximately 30 to 60 minutes before meals.  
     
     
         32 . A method as defined is  claim 25 , wherein the step of administering comprises administering the composition orally.  
     
     
         33 . A method as defined in  claim 25 , wherein the composition further comprises chromium and gymnemic acid.  
     
     
         34 . A method as defined in  claim 33 , wherein the composition comprises niacin-bound chromium.  
     
     
         35 . A method as defined in  claim 34 , wherein the composition comprises oxygen-coordinated niacin-bound chromium.  
     
     
         36 . A method as defined in  claim 33 , wherein the composition comprises gymnemic acid derived from a plant of the genus Gymnema.  
     
     
         37 . A method as defined in  claim 36 , wherein the plant is Gymnema sylvestre.  
     
     
         38 . A method as defined in  claim 33 , wherein the step of administering comprises administering approximately 10 micrograms to approximately 1,000 micrograms of chromium and approximately 10 milligrams to approximately 1,000 milligrams of gymnemic acid daily.  
     
     
         39 . A method as defined in  claim 38 , wherein the step of administering comprises administering approximately 400 micrograms of chromium and approximately 100 milligrams of gymnemic acid daily.  
     
     
         40 . A method for increasing fat oxidation in a person or other mammal comprising: 
 identifying a person or other mammal that can benefit from increased fat oxidation; and    administering to the person or other mammal a composition comprising hydroxycitric acid in an amount sufficient to increase fat oxidation in the person or other mammal.    
     
     
         41 . A method as defined in  claim 40 , wherein the composition comprises hydroxycitric acid bound to calcium and potassium.  
     
     
         42 . A method as defined in  claim 40 , wherein the composition comprises hydroxycitric acid is derived from a plant of the genus Garcinia.  
     
     
         43 . A method as defined in  claim 42 , wherein the plant is  Garcinia cambogia.    
     
     
         44 . A method as defined in  claim 40 , wherein the step of administering comprises administering approximately 100 milligrams to approximately 5,000 milligrams of hydroxycitric acid daily.  
     
     
         45 . A method as defined in  claim 44 , wherein the step of administering comprises administering approximately 2,700 milligrams to approximately 2,800 milligrams of hydroxycitric acid daily.  
     
     
         46 . A method as defined in  claim 40 , wherein the step of administering comprises administering the composition daily in three substantially equally divided doses, approximately 30 to 60 minutes before meals.  
     
     
         47 . A method as defined is  claim 40 , wherein the step of administering comprises administering the composition orally.  
     
     
         48 . A method as defined in  claim 40 , wherein the composition further comprises chromium and gymnemic acid.  
     
     
         49 . A method as defined in  claim 48 , wherein the composition comprises niacin-bound chromium.  
     
     
         50 . A method as defined in  claim 49 , wherein the composition comprises oxygen-coordinated niacin-bound chromium.  
     
     
         51 . A method as defined in  claim 50 , wherein the composition comprises gymnemic acid is derived from a plant of the genus Gymnema.  
     
     
         52 . A method as defined in  claim 51 , wherein the plant is  Gymnema sylvestre.    
     
     
         53 . A method as defined in  claim 48 , wherein the step of administering comprises administering approximately 10 micrograms to approximately 1,000 micrograms of chromium and approximately 10 milligrams to approximately 1,000 milligrams of gymnemic acid daily.  
     
     
         54 . A method as defined in  claim 53 , wherein the step of administering comprises administering approximately 400 micrograms of chromium and approximately 100 milligrams of gymnemic acid daily.  
     
     
         55 . A method for reducing excess, or maintaining healthy, body weight in a person or other mammal comprising: 
 identifying a person or other mammal suffering, or at risk for suffering, from excess body weight; and    administering to the person or other mammal a composition comprising hydroxycitric acid, chromium and gymnemic acid in an amount sufficient to reduce excess, or maintain healthy, body weight in the person or other mammal.    
     
     
         56 . A method as defined in  claim 55 , wherein the composition comprises hydroxycitric acid bound to calcium and potassium.  
     
     
         57 . A method as defined in  claim 55 , wherein the hydroxycitric acid is derived from a plant of the genus Garcinia.  
     
     
         58 . A method as defined in  claim 57 , wherein the plant is  Garcinia cambogia.    
     
     
         59 . A method as defined in  claim 55 , wherein the composition comprises niacin-bound chromium.  
     
     
         60 . A method as defined in  claim 59 , wherein the composition comprises oxygen-coordinated niacin-bound chromium.  
     
     
         61 . A method as defined in  claim 55 , wherein the gymnemic acid is derived from a plant of the genus Gymnema.  
     
     
         62 . A method as defined in  claim 61 , wherein the plant is  Gymnema sylvestre.    
     
     
         63 . A method as defined in  claim 55 , wherein the step of administering comprises administering approximately 100 milligrams to approximately 5,000 milligrams of hydroxycitric acid, approximately 10 micrograms to approximately 1,000 micrograms of chromium, and approximately 10 milligrams to approximately 1,000 milligrams of gymnemic acid daily.  
     
     
         64 . A method as defined in  claim 63 , wherein the step of administering comprises administering approximately 2,700 milligrams to approximately 2,800 milligrams of hydroxycitric acid, approximately 400 micrograms of chromium, and approximately 100 milligrams of gymnemic acid daily.  
     
     
         65 . A method as defined in  claim 55 , wherein the step of administering comprises administering the composition daily in three substantially equally divided doses, approximately 30 to 60 minutes before meals.  
     
     
         66 . A method as defined is  claim 55 , wherein the step of administering comprises administering the composition orally.  
     
     
         67 . A method for reducing excess, or maintaining healthy, body mass index in a person or other mammal comprising: 
 identifying a person or other mammal suffering, or at risk for suffering, from excess body weight; and    administering to the person or other mammal a composition comprising hydroxycitric acid, chromium and gymnemic acid in an amount sufficient to reduce excess or maintain healthy body mass index in the person or other mammal.    
     
     
         68 . A method as defined in  claim 67 , wherein the composition comprises hydroxycitric acid bound to calcium and potassium.  
     
     
         69 . A method as defined in  claim 67 , wherein the hydroxycitric acid is derived from a plant of the genus Garcinia.  
     
     
         70 . A method as defined in  claim 69 , wherein the plant is  Garcinia cambogia.    
     
     
         71 . A method as defined in  claim 67  wherein the composition comprises niacin-bound chromium.  
     
     
         72 . A method as defined in  claim 71  wherein the composition comprises oxygen-coordinated niacin-bound chromium.  
     
     
         73 . A method as defined in  claim 67  wherein the gymnemic acid is derived from a plant of the genus Gymnema.  
     
     
         74 . A method as defined in  claim 73 , wherein the plant is  Gymnema sylvestre.    
     
     
         75 . A method as defined in  claim 67 , wherein the step of administering comprises administering approximately 100 milligrams to approximately 5,000 milligrams of hydroxycitric acid, approximately 10 micrograms to approximately 1,000 micrograms of chromium, and approximately 10 milligrams to approximately 1,000 milligrams of gymnemic acid daily.  
     
     
         76 . A method as defined in  claim 75 , wherein the step of administering comprises administering approximately 2,700 milligrams to approximately 2,800 milligrams of hydroxycitric acid, approximately 400 micrograms of chromium, and approximately 100 milligrams of gymnemic acid daily.  
     
     
         77 . A method as defined in  claim 67 , wherein the step of administering comprises administering the composition daily in three substantially equally divided doses, approximately 30 to 60 minutes before meals.  
     
     
         78 . A method as defined is  claim 67 , wherein the step of administering comprises administering the composition orally.  
     
     
         79 . A method for decreasing appetite and/or reducing food intake in a person or other mammal comprising: 
 identifying a person or other mammal that can benefit from decreased appetite and/or reduced food intake; and    administering to the person or other mammal a composition comprising hydroxycitric acid, chromium and gymnemic acid in an amount sufficient to decrease appetite and/or reduce food intake in the person or other mammal.    
     
     
         80 . A method as defined in  claim 79 , wherein the composition comprises hydroxycitric acid bound to calcium and potassium.  
     
     
         81 . A method as defined in  claim 79 , wherein the hydroxycitric acid is derived from a plant of the genus Garcinia.  
     
     
         82 . A method as defined in  claim 81 , wherein the plant is  Garcinia cambogia.    
     
     
         83 . A method as defined in  claim 79 , wherein the composition comprises niacin-bound chromium.  
     
     
         84 . A method as defined in  claim 83 , wherein the composition comprises oxygen-coordinated niacin-bound chromium.  
     
     
         85 . A method as defined in  claim 79 , wherein the gymnemic acid is derived from a plant of the genus Gymnema.  
     
     
         86 . A method as defined in  claim 85 , wherein the plant is  Gymnema sylvestre.    
     
     
         87 . A method as defined in  claim 79 , wherein the step of administering comprises administering approximately 100 milligrams to approximately 5,000 milligrams of hydroxycitric acid, approximately 10 micrograms to approximately 1,000 micrograms of chromium, and approximately 10 milligrams to approximately 1,000 milligrams of gymnemic acid daily.  
     
     
         88 . A method as defined in  claim 87 , wherein the step of administering comprises administering approximately 2,700 milligrams to approximately 2,800 milligrams of hydroxycitric acid, approximately 400 micrograms of chromium, and approximately 100 milligrams of gymnemic acid daily.  
     
     
         89 . A method as defined in  claim 79 , wherein the step of administering comprises administering the composition daily in three substantially equally divided doses, approximately 30 to 60 minutes before meals.  
     
     
         90 . A method as defined is  claim 79 , wherein the step of administering comprises administering the composition orally.  
     
     
         91 . A method for decreasing total cholesterol, LDL cholesterol and/or triglyceride levels, and/or increasing HDL cholesterol levels, in a person or other mammal comprising: 
 identifying a person or other mammal that can benefit from decreased total cholesterol, LDL cholesterol and/or triglyceride levels, and/or increased HDL cholesterol levels; and    administering to the person or other mammal a composition comprising hydroxycitric acid, chromium and gymnemic acid in an amount sufficient to decrease total cholesterol, LDL cholesterol and/or triglyceride levels, and/or increase HDL cholesterol levels, in the person or other mammal.    
     
     
         92 . A method as defined in  claim 91 , wherein the composition comprises hydroxycitric acid bound to calcium and potassium.  
     
     
         93 . A method as defined in  claim 91 , wherein the hydroxycitric acid is derived from a plant of the genus Garcinia.  
     
     
         94 . A method as defined in  claim 93 , wherein the plant is  Garcinia cambogia.    
     
     
         95 . A method as defined in  claim 91 , wherein the composition comprises niacin-bound chromium.  
     
     
         96 . A method as defined in  claim 95 , wherein the composition comprises oxygen-coordinated niacin-bound chromium.  
     
     
         97 . A method as defined in  claim 91 , wherein the gymnemic acid is derived from a plant of the genus Gymnema.  
     
     
         98 . A method as defined in  claim 97 , wherein the plant is  Gymnema sylvestre.    
     
     
         99 . A method as defined in  claim 91 , wherein the step of administering comprises administering approximately 100 milligrams to approximately 5,000 milligrams of hydroxycitric acid, approximately 10 micrograms to approximately 1,000 micrograms of chromium, and approximately 10 milligrams to approximately 1,000 milligrams of gymnemic acid daily.  
     
     
         100 . A method as defined in  claim 99 , wherein the step of administering comprises administering approximately 2,700 milligrams to approximately 2,800 milligrams of hydroxycitric acid, approximately 400 micrograms of chromium, and approximately 100 milligrams of gymnemic acid daily.  
     
     
         101 . A method as defined in  claim 91 , wherein the step of administering comprises administering the composition daily in three substantially equally divided doses, approximately 30 to 60 minutes before meals.  
     
     
         102 . A method as defined is  claim 91 , wherein the step of administering comprises administering the composition orally.

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