Method and composition for inhibiting arteriosclerosis

Abstract

The present invention has for its object to provide a method and a composition for achieving a more efficient recovery of the antioxidant activity of plasma LDL, or even augmentation thereof, which has been depressed by the use of an antihyperlipidemic or cholesterol-lowering drug to thereby insure a potentiated antiarteriosclerotic efficacy. A method for inhibiting arteriosclerosis, which comprises using a combination of a cholesterol-lowering agent and a reduced coenzyme Q 10 represented by the following formula (1), and a composition for inhibiting arteriosclerosis containing both a cholesterol-lowering agent and said reduced coenzyme Q 10 .

1 . A method for inhibiting arteriosclerosis, which comprises using a combination of a cholesterol-lowering agent and a reduced coenzyme Q 10  represented by the following formula (1).  
       
         
           
           
               
               
           
         
       
     
     
         2 . The method according to  claim 1 , 
 wherein the cholesterol-lowering agent is a hydroxymethylglutaryl-CoA reductase inhibitor.    
     
     
         3 . A composition for inhibiting arteriosclerosis, which comprises both a cholesterol-lowering agent and a reduced coenzyme Q 10  represented by the following formula (1).  
       
         
           
           
               
               
           
         
       
     
     
         4 . The composition according to  claim 3 , 
 wherein the cholesterol-lowering agent is a hydroxymethylglutaryl-CoA reductase inhibitor.