Substituted benzimidazoles, their preparation and their use as agents against parasitic protozoa

Abstract

The present invention relates to new substituted benzimidazoles, their preparation and their use as agents against parasitic protozoa. The active compounds are characterized by the following formula (I): in which X 1 represents chlorine or bromine, R 1 represents hydrogen or C 1-4 -alkyl, R 3 represents fluoroalkyl, R 2 represents the radical R 4 represents alkyl or substituted phenyl, R 5 represents alkyl.

1 . The benzimidazoles of the formula (I)  
       
         
           
           
               
               
           
         
       
       in which 
 X 1  represents chlorine or bromine,  
 R 1  represents hydrogen or C 1-4 -alkyl,  
 R 3  represents fluoroalkyl,  
 R 2  represents the radical  
                     
 R 4  represents alkyl or substituted phenyl,  
 R 5  represents alkyl.  
 
     
     
         2 . Process for the preparation of the benzimidazoles of the formula (I)  
       
         
           
           
               
               
           
         
       
       in which 
 X 1  represents chlorine or bromine  
 R 1  represents hydrogen or C 1-4 -alkyl,  
 R 3  represents fluoroalkyl,  
 R 2  represents the radical  
                     
 R 4  represents alkyl or substituted phenyl  
 R 5  represents alkyl,  
 characterized in that 
 1H-benzimidazoles of the formula (II)  
                     
 in which  
 
 X 1  and R 3  have the meaning indicated above,  
 are reacted with an alkylating agent of the formula (III) 
 A—CHR 1 R 2   (III), 
 in which  
 A represents a suitable leaving group,  
 R 1  and R 2  have the meaning indicated above,  
 if appropriate in the presence of diluents and/or reaction auxiliaries.  
 
     
     
         3 . Composition against parasitic protozoa, characterized in that it contains at least one substituted benzimidazole of the formula (I) according to  claim 1 .  
     
     
         4 . Process for controlling parasitic protozoa, characterized in that substituted benzimidazoles of the formula (I) according to  claim 1  are allowed to act on these and/or their environment.  
     
     
         5 . Use of substituted benzimidazoles of the formula (I) according to  claim 1  for controlling parasitic protozoa.  
     
     
         6 . Use of substituted benzimidazoles of the formula (I) according to  claim 1  for the preparation of compositions/against parasitic protozoa.  
     
     
         7 . Mixtures of substituted benzimidazoles of the formula (I) according to  claim 1  with polyether antibiotics or synthetic coccidiosis agents for controlling parasitic protozoa.