US2004005352A1PendingUtilityA1

Biologically functionalized porous microspheres

55
Priority: Apr 16, 2002Filed: Apr 16, 2003Published: Jan 8, 2004
Est. expiryApr 16, 2022(expired)· nominal 20-yr term from priority
Inventors:Gabriel P. LopezTione BurandaVenkata Rama Rao GoparajuJinman HuangLinnea K. IstaLarry A. Sklar
A61K 9/1272A61K 9/1617
55
PatentIndex Score
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Claims

Abstract

The present invention provides functionalized mesoporous microspheres comprising a microsphere including surface mesopores; a lipid bilayer covering at least a portion of the microsphere; and enclosed mesoporous spaces comprising the surface mesopores and respective portions of the lipid bilayer.

Claims

exact text as granted — not AI-modified
What is claimed is:  
     
         1 . A product comprising: 
 a microsphere including surface mesopores;    a lipid bilayer covering at least a portion of said microsphere; and    enclosed mesoporous spaces comprising said surface mesopores and respective portions of said lipid bilayer.    
     
     
         2 . The product of  claim 1 , wherein said enclosed mesoporous spaces contain a dispersion.  
     
     
         3 . The product of  claim 2 , wherein said enclosed mesoporous spaces contain a solution.  
     
     
         4 . The product of  claim 2 , wherein said enclosed mesoporous spaces contain a colloidal suspension.  
     
     
         5 . The product of  claim 1 , wherein said microsphere has internal mesopores within said microsphere in communication with at least one of said surface mesopores.  
     
     
         6 . The product of  claim 1 , wherein said surface mesopores are 10-20 nm in diameter.  
     
     
         7 . The product of  claim 1 , wherein said surface mesopores are 2 nm in diameter.  
     
     
         8 . The product of  claim 1 , wherein said surface mesopores are 5 nm in diameter.  
     
     
         9 . The product of  claim 1 , wherein said surface mesopores are 10 nm in diameter.  
     
     
         10 . The product of  claim 1 , wherein all of said mesopores are the same size.  
     
     
         11 . The product of  claim 1 , wherein said mesopores are divided into a plurality of regions and within each region, said mesopores are the same size.  
     
     
         12 . The product of  claim 1 , wherein said microsphere has a diameter of 0.5 to 20 μm  
     
     
         13 . The product of  claim 1 , wherein said microsphere has a diameter of about 15 μm.  
     
     
         14 . The product of  claim 1 , wherein at least one of said enclosed mesoporous spaces contains an indicator.  
     
     
         15 . The product of  claim 1 , wherein at least one of said enclosed mesoporous spaces contains a biomolecule.  
     
     
         16 . The product of  claim 1 , wherein at least one of said enclosed mesoporous spaces contains an organelle.  
     
     
         17 . The product of  claim 1 , wherein at least one of said enclosed mesoporous spaces contains a whole cell.  
     
     
         18 . The product of  claim 1 , wherein at least one of said enclosed mesoporous spaces contains a magnetic material.  
     
     
         19 . The product of  claim 1 , wherein at least one of said enclosed mesoporous spaces contains a charged material.  
     
     
         20 . The product of  claim 1 , wherein said lipid bilayer includes at least one integral protein therein.  
     
     
         21 . The product of  claim 1 , wherein said lipid bilayer includes at least one peripheral protein thereon.  
     
     
         22 . A product comprising: 
 at least one external phase comprising an external dispersant; and    a plurality of functionalized microspheres dispersed in said external dispersant, each of said functionalized microspheres comprising: 
 a microsphere body including surface mesopores;  
 a lipid bilayer covering at least a portion of said microsphere; and  
 enclosed mesoporous spaces comprising said surface mesophores and respective portions of said lipid bilayer.  
   
     
     
         23 . The product of  claim 22 , wherein said enclosed mesoporous spaces include an internal dispersant.  
     
     
         24 . The product of  claim 23 , wherein said internal dispersant is different from said external dispersant.  
     
     
         25 . The product of  claim 23 , wherein said enclosed mesoporous spaces contain a solution.  
     
     
         26 . The product of  claim 23 , wherein said enclosed mesoporous spaces contain a colloidal suspension.  
     
     
         27 . The product of  claim 22 , wherein said at least one external phase comprises an external dispersion including said external dispersant.  
     
     
         28 . The product of  claim 22 , wherein said microsphere has internal mesopores within said microsphere in communication with at least one of said surface mesopores.  
     
     
         29 . The product of  claim 22 , wherein said surface mesopores are 10-20 nm in diameter.  
     
     
         30 . The product of  claim 22 , wherein said surface mesopores are 2 nm in diameter.  
     
     
         31 . The product of  claim 22 , wherein said surface mesopores are 5 nm in diameter.  
     
     
         32 . The product of  claim 22 , wherein said surface mesopores are 10 nm in diameter.  
     
     
         33 . The product of  claim 22 , wherein all of said mesopores are the same size.  
     
     
         34 . The product of  claim 22 , wherein said mesopores are divided into a plurality of regions and within each region, said mesopores are the same size.  
     
     
         35 . The product of  claim 22 , wherein each of said microspheres has a diameter of 0.5 to 20 μm.  
     
     
         36 . The product of  claim 22 , wherein each of said microspheres has a diameter of about 15 μm.  
     
     
         37 . The product of  claim 22 , wherein at least one of said enclosed mesoporous spaces contains an indicator.  
     
     
         38 . The product of  claim 22 , wherein at least one of said enclosed mesoporous spaces contains a biomolecule.  
     
     
         39 . The product of  claim 22 , wherein at least one of said enclosed mesoporous spaces contains an organelle.  
     
     
         40 . The product of  claim 22 , wherein at least one of said enclosed mesoporous spaces contains a whole cell.  
     
     
         41 . The product of  claim 22 , wherein at least one of said enclosed mesoporous spaces contains a magnetic material.  
     
     
         42 . The product of  claim 22 , wherein at least one of said enclosed mesoporous spaces contains a charged material.  
     
     
         43 . A method comprising the steps of: 
 transferring a substance from at least one external phase comprising a dispersant to an enclosed mesoporous space of a functionalized microsphere; and    reacting said substance with at least one internal phase in said enclosed mesoporous space, wherein said enclosed mesoporous space comprises a surface mesopore of said microsphere body of said functionalized microsphere and a portion of a lipid bilayer covering said microsphere body.    
     
     
         44 . The method of  claim 43 , wherein said enclosed mesoporous space includes an internal dispersant.  
     
     
         45 . The method of  claim 44 , wherein said internal dispersant is different from said external dispersant.  
     
     
         46 . The method of  claim 44 , wherein said enclosed mesoporous spaces contain a solution.  
     
     
         47 . The method of  claim 44 , wherein said enclosed mesoporous space contains a colloidal suspension.  
     
     
         48 . The method of  claim 43 , wherein said at least one external phase comprises an external dispersion including said external dispersant.  
     
     
         49 . The method of  claim 43 , wherein said microsphere has internal mesopores within said microsphere in communication with at least one of said surface mesopores.  
     
     
         50 . The method of  claim 43 , wherein said surface mesopore is 10-20 nm in diameter.  
     
     
         51 . The method of  claim 43 , wherein said surface mesopore is 2 nm in diameter.  
     
     
         52 . The method of  claim 43 , wherein said surface mesopore is 5 nm in diameter.  
     
     
         53 . The method of  claim 43 , wherein said surface mesopore is 10 nm in diameter.  
     
     
         54 . The method of  claim 43 , wherein all of said mesopores are the same size.  
     
     
         55 . The method of  claim 43 , wherein said mesopores are divided into a plurality of regions and within each region, said mesopores are the same size.  
     
     
         56 . The method of  claim 43 , wherein said microsphere has a diameter of 0.5 to 20 μm  
     
     
         57 . The method of  claim 43 , wherein said microsphere has a diameter of about 15 μm.  
     
     
         58 . The method of  claim 43 , wherein said enclosed mesoporous space contains an indicator.  
     
     
         59 . The method of  claim 43 , wherein said enclosed mesoporous space contains a biomolecule.  
     
     
         60 . The method of  claim 43 , wherein said enclosed mesoporous space contains an organelle.  
     
     
         61 . The method of  claim 43 , wherein said enclosed mesoporous space contains a whole cell.  
     
     
         62 . The method of  claim 43 , wherein said enclosed mesoporous space contains a magnetic material.  
     
     
         63 . The method of  claim 43 , wherein said enclosed mesoporous space contains a charged material.

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