Therapeutic uses of N-terminal BPI protein products in ANCA-positive patients

Abstract

Improved therapeutic uses for N-terminal BPI protein products are described in patients that have BPI-reactive anti-neutrophil cytoplasmic antibodies.

What is claimed are:  
     
         1 . In a method of treating a subject with a bactericidal/permeability-increasing (BPI) protein product, the improvement comprising administering an N-terminal BPI protein product to a subject having non-N-terminal-BPI-reactive antibodies.  
     
     
         2 . The method of  claim 1  wherein the N-terminal BPI protein product is being administered to a human subject to ameliorate adverse effects associated with endotoxin in circulation.  
     
     
         3 . The method of  claim 1  wherein the N-terminal BPI protein product is being administered to a human subject to ameliorate adverse effects associated with meningococcemia.  
     
     
         4 . The method of  claim 1  wherein the N-terminal BPI protein product is being administered to a human subject to ameliorate adverse effects associated with hemorrhagic trauma.  
     
     
         5 . The method of  claim 1  wherein the N-terminal BPI protein product is being administered to a subject to ameliorate adverse effects associated with burn injury.  
     
     
         6 . The method of  claim 1  wherein the subject being treated is suffering from a gram-negative bacterial infection.  
     
     
         7 . The method of  claim 1  wherein the subject being treated is suffering from a gram-positive bacterial or mycoplasmal infection.  
     
     
         8 . The method of  claim 1  wherein the subject being treated is suffering from a fungal infection.  
     
     
         9 . The method of  claim 1  wherein the subject being treated is suffering from a protozoan infection.  
     
     
         10 . The method of  claim 1  wherein the subject being treated is suffering from a chlamydial infection.  
     
     
         11 . The method of  claim 1  wherein the subject being treated is suffering from a mycobacterial infection.  
     
     
         12 . The method of  claim 1  wherein the subject being treated is suffering from a chronic inflammatory disease.  
     
     
         13 . The method of  claim 1  wherein the N-terminal BPI protein product is being administered to a subject to inhibit angiogenesis.  
     
     
         14 . The method of  claim 1  wherein the N-terminal BPI protein product is being administered to a subject to promote fibrinolysis.  
     
     
         15 . The method of  claim 1  wherein the N-terminal BPI protein product is an amino-terminal fragment of BPI protein having a molecular weight of about 20 kD to 25 kD.  
     
     
         16 . The method of  claim 1  wherein the BPI protein product is rBPI 23  or a dimeric form thereof.  
     
     
         17 . The method of  claim 1  wherein the BPI protein product is rBPI 21 .