Antinfective free intramammary veterinary composition

Abstract

An antiinfective-free formulation for prophylactic traetment of mastitis in dry cows comprises a seal formulation having approximately 65% by weight of bismuth sub-nitrate in a gel based on aluminium stearate. The seal formulation is prepared by adding the bismuth sub-nitrate to the gel base in at least two separate stages.

1 . An antiinfective-free formulation for prophylaxis of intramammary infection comprising a seal formulation to provide an antiinfective-free physical barrier in the teat canal.  
     
     
         2 . A formulation as claimed in  claim 1  wherein the seal formulation comprises a non-toxic heavy metal salt in a gel base.  
     
     
         3 . A formulation as claimed in  claim 2  wherein the seal formulation contains at least 40% by weight of the heavy metal salt.  
     
     
         4 . A formulation as claimed in  claim 3  wherein the seal formulation contains from 50% to 75% by weight of the heavy metal salt.  
     
     
         5 . A formulation as claimed in  claim 4  wherein the seal formulation contains approximately 65% by weight of the heavy metal salt.  
     
     
         6 . A formulation as claimed in any of  claims 2  to  5  wherein the salt is bismuth sub-nitrate.  
     
     
         7 . A formulation as claimed in any of  claims 1  to  6  wherein the base is a gel based on aluminium stearate.  
     
     
         8 . A formulation as claimed in any of  claims 1  to  7  wherein the base includes liquid paraffin as a vehicle.  
     
     
         9 . An antiinfective-free formulation substantially as hereinbefore described with reference to the Examples.  
     
     
         10 . An antiinfective-free method of prophylactic treatment of mammary disorders in non-human animals during an animal's dry period by sealing the teat canal with a seal formulation to provide a physical barrier in the teat canal.  
     
     
         11 . A prophylactic method of controlling infection of the mammary gland by a mastitis-causing organism comprising sealing the gland with a seal formulation to provide a physical barrier in the teat canal.  
     
     
         12 . A method as claimed in  claim 10  or  11  wherein the seal formulation comprises a non-toxic heavy metal salt in a gel base.  
     
     
         13 . A method as claimed in any of  claims 10  to  12  wherein the seal formulation contains at least 40% by weight of the heavy metal salt.  
     
     
         14 . A method as claimed in  claim 13  wherein the seal formulation contains from 50% to 75% by weight of the heavy metal salt.  
     
     
         15 . A method as claimed in  claim 14  wherein the seal formulation contains approximately 65% by weight of the heavy metal salt.  
     
     
         16 . A method as claimed in any of  claims 10  to  15  wherein the salt is bismuth sub-nitrate.  
     
     
         17 . A method as claimed in any of  claims 10  to  16  wherein the base is a gel based on aluminium stearate.  
     
     
         18 . A method as claimed in any of  claims 10  to  17  wherein the base includes liquid paraffin as a vehicle.  
     
     
         19 . An antiinfective-free method of prophylactic treatment of mammary disorders substantially as hereinbefore described with reference to the Examples.  
     
     
         20 . A process for preparing a seal formulation comprising the steps of adding a non-toxic heavy metal salt to a gel base in at least two separate stages.  
     
     
         21 . A process as claimed in  claim 19  wherein a first portion of heavy metal salt is added to a gel base in a first stage and a second portion of the heavy metal salt is added to a gel base containing the first portion of the heavy metal salt.  
     
     
         22 . A process as claimed in  claim 21  wherein the weight ratio of the second portion of the heavy metal salt to the first portion of the heavy metal salt is at least 1:1.  
     
     
         23 . A process as claimed in  claim 22  wherein the weight ratio is approximately 2:1.  
     
     
         24 . A process as claimed in any of  claims 20  to  23  wherein the seal formulation contains at least 40% by weight of the heavy metal salt.  
     
     
         25 . A process as claimed in  claim 24  wherein the seal formulation contains from 50% to 75% by weight of the heavy metal salt.  
     
     
         26 . A process as claimed in any of  claims 20  to  25  wherein the seal formulation contains approximately 65% by weight of the heavy metal salt.  
     
     
         27 . A process as claimed in any of  claims 20  to  26  wherein the salt is bismuth sub-nitrate.  
     
     
         28 . A process as claimed in any of  claims 20  to  27  wherein the base is a gel based on aluminium stearate.  
     
     
         29 . A process as claimed in any of  claims 20  to  28  wherein the gel contains liquid paraffin as a vehicle.  
     
     
         30 . A process substantially as hereinbefore described with reference to the Examples.  
     
     
         31 . A seal formulation whenever prepared by a process as claimed in any of  claims 20  to  30 .