Popping oral administration form

Abstract

Disclosed are popping pharmaceutical oral administration forms, which comprise an active ingredient, and pressurized gas trapped within cavities in a pharmaceutically acceptable material in a manner that allows the gas to escape from the administration form upon dissolution or shattering of said form. Such an oral administration form may be popular with children that will prefer it on other ones, which do not pop. Methods for preparation of such oral administration forms are also disclosed.

1 . An oral administration form comprising an active ingredient and a pressurized gas, said pressurized gas being trapped in cavities within a pharmaceutically acceptable material, in a manner that allows its escape upon dissolution or shattering of the administration form.  
     
     
         2 . An oral administration form according to  claim 1 , wherein said pharmaceutically acceptable material comprises said active ingredient.  
     
     
         3 . An oral administration form according to  claim 1 , comprising more than one active ingredient.  
     
     
         4 . An oral administration form according to  claim 1 , including a pharmaceutically acceptable carrier.  
     
     
         5 . An oral administration form according to  claim 1 , wherein said active ingredient includes a prescription drug.  
     
     
         6 . An oral administration form according to  claim 1 , wherein said active ingredient includes a drug sold over the counter.  
     
     
         7 . An oral administration form according to  claim 1 , wherein said active ingredient includes a neutraceutical.  
     
     
         8 . An oral administration form according to  claim 1 , suitable for veterinary use.  
     
     
         9 . An oral administration form according to  claim 1 , wherein said active ingredient includes a vitamin, an expectorant, an analgesic, an antipyretic, an anti-inflamatory, an antibiotic, or an anti-hypertensive agent.  
     
     
         10 . An oral administration form according to  claim 1 , wherein said active ingredient is selected from paracetamol, diphenhydramine, dextromethorphan, loratadine, lidocaine, ibuprofen, pseudoephedrine, enalapril and calcium carbonate.  
     
     
         11 . An oral administration form according to  claim 1 , wherein said active ingredient includes a vitamin or a mineral.  
     
     
         12 . An oral administration form according to  claim 11 , wherein said vitamin or mineral is selected from vitamin C, vitamin E, biotin, selenium and zinc.  
     
     
         13 . An oral administration form according to  claim 7 , wherein said neutraceutical is selected from echinacea, propolis and soy extract.  
     
     
         14 . An oral administration form according to  claim 8 , wherein said active ingredient is selected from nitroscanate, abamectin and ivermectin.  
     
     
         15 . An oral administration form according to  claim 1 , wherein said active ingredient is coated by a coating.  
     
     
         16 . An oral administration form according to  claim 15 , wherein said coating comprises taste-masking materials, biodegradable polymers, enteric polymers, humidity protective materials and/or oxidation protective materials.  
     
     
         17 . An oral administration form according to  claim 16 , wherein said coating is a taste masking coating.  
     
     
         18 . An oral administration form according to  claim 1 , having a form of a tablet, powder, pellets, capsule, syrup, oil, suspension, gel, drops, or candylike form.  
     
     
         19 . An oral administration form according to  claim 1 , wherein said pharmaceutically acceptable material is selected from sugars, corn syrup or mixtures thereof.  
     
     
         20 . An oral administration form according to  claim 1 , wherein said gas is selected from carbon dioxide, nitrogen, air, helium, argon, and neon.  
     
     
         21 . A method for preparing an oral administration form according to  claim 1  comprising: 
 (i) preparing a mixture comprising an active ingredient, and a pharmaceutically acceptable material trapping pressurized gas within cavities thereof; and  
 (ii) processing said mixture to obtain an administration form that permits said gas to escape upon dissolution or shattering of the administration form.  
 
     
     
         22 . A method according to  claim 21 , wherein the mixture in (i) comprising more than one active ingredient.  
     
     
         23 . A method according to  claim 21 , wherein the mixture obtained in (i) further comprising other excipients.  
     
     
         24 . A method for preparing a gasified oral administration form comprising: 
 (a) melting a pharmaceutically acceptable carrier material to obtain a melt;    (b) adding a gas and at least one active ingredient into the melt under superatmospheric pressure to obtain a liquid pharmaceutical composition;    (c) casting the liquid pharmaceutical composition into a mold under superatmospheric pressure; and    (d) solidifying the cast pharmaceutical composition under conditions suitable to obtain a gasified oral administration form.    
     
     
         25 . A method according to  claim 24 , wherein in (ii) a pharmaceutically acceptable excipient is also added into the melt.  
     
     
         26 . A method for preparing a gasified oral administration form comprising: 
 (i) melting a pharmaceutically acceptable carrier material to obtain a melt;    (ii) adding a gas and at least one active ingredient into the melt under superatmospheric pressure to obtain a liquid pharmaceutical composition;    (iii) casting the liquid pharmaceutical composition into a mold under superatmospheric pressure;    (iv) solidifying the liquid pharmaceutical composition to obtain a gasified solid pharmaceutical composition;    (v) grinding the gasified solid pharmaceutical composition to obtain a popping powder; and    (vi) processing the obtained powder to obtain an oral administration form which produces popping sensation upon wetting.    
     
     
         27 . A method according to  claim 26 , wherein in (ii) a pharmaceutically acceptable excipient is also added into the melt.  
     
     
         28 . A method according to  claim 26 , wherein an excipient is added to the popping powder obtained in (v) to be processed in (vi).  
     
     
         29 . A method for treating a subject comprising administering to said subject a pharmaceutical administration form according to  claim 1 .  
     
     
         30 . A method according to  claim 29 , wherein said pharmaceutical administration form is of a prescription drug.  
     
     
         31 . A method for administration of an active ingredient to a subject in need thereof, said method comprising orally administering to said subject an oral administration form according to  claim 1 .  
     
     
         32 . A method according to  claim 31 , wherein said subject is reluctant to swallowing pharmaceutical administration forms that do not produce popping sensation upon wetting.