Methods for treating an impairment in memory consolidation

Abstract

Impairments in memory consolidation are treated with an amphetamine compound. In one embodiment, the method includes administering an 1-amphetamine compound. In another embodiment, the method includes administering an 1-methamphetamine compound. The method can include determining memory consolidation before, during and/or after administering the amphetamine compound.

What is claimed is:  
     
         1 . A method of improving memory consolidation in a human, comprising the step of administering at least one member selected from the group consisting of 1-amphetamine and 1-methamphetamine to a human having an impairment in memory consolidation.  
     
     
         2 . The method of  claim 1 , wherein 1-amphetamine is administered, and wherein the 1-amphetamine is administered as a component of a composition that includes at least about 80 mole percent 1-amphetamine relative to a total amphetamine content of the composition.  
     
     
         3 . The method of  claim 1 , wherein 1-methamphetamine is administered, and wherein the 1-methamphetamine is administered as a component of a composition that includes at least about 80 mole percent 1-methamphetamine relative to a total methamphetamine content of the composition.  
     
     
         4 . The method of  claim 1 , wherein the impairment in memory consolidation in the human is determined by a Rey Auditory Verbal Learning Test.  
     
     
         5 . The method of  claim 1 , wherein 1-amphetamine and 1-methamphetamine is administered in a single dose.  
     
     
         6 . The method of  claim 5 , wherein the single dose is a dose of at least about a 0.01 mg dose.  
     
     
         7 . The method of  claim 1 , wherein the 1-amphetamine and 1-methamphetamine is administered in multiple doses.  
     
     
         8 . The method of  claim 7 , wherein each dose of the multiple doses is administered at a dose of at least about a 0.01 mg dose.  
     
     
         9 . A method of improving memory consolidation in a human, comprising the step of administering at least one member selected from the group consisting of 1-amphetamine and 1-methamphetamine to a human having an impairment in memory consolidation, wherein the 1-amphetamine is administered as a component of a composition that includes at least about 80 mole percent 1-amphetamine relative to a total amphetamine content in the composition and the 1-methamphetamine is administered as a component of a composition that includes at least about 80 mole percent 1-methamphetamine relative to a total methamphetamine content in the composition.  
     
     
         10 . The method of  claim 9 , wherein the impairment in memory consolidation in the human is determined by a Rey Auditory Verbal Learning Test.  
     
     
         11 . The method of  claim 9 , wherein the 1-amphetamine and 1-methamphetamine is administered as a single dose.  
     
     
         12 . The method of  claim 11 , wherein the single dose is a dose of at least about a 0.01 mg dose.  
     
     
         13 . The method of  claim 9 , wherein the 1-amphetamine and 1-methamphetamine is administered in multiple doses.  
     
     
         14 . The method of  claim 13 , wherein each dose of the multiple doses is administered at a dose of at least about a 0.01 mg dose.  
     
     
         15 . A method of improving memory consolidation in a human, comprising the step of administering at least one member selected from the group consisting of 1-amphetamine and 1-methamphetamine to a human having an impairment in memory consolidation, wherein the 1-amphetamine is administered as a component of a composition that includes at least about 90 mole percent 1-amphetamine relative to a total amphetamine content in the composition and the 1-methamphetamine is administered as a component of a composition that includes at least about 90 mole percent 1-methamphetamine relative to a total methamphetamine content in the composition.  
     
     
         16 . A method of improving memory consolidation in a human, comprising the steps of: 
 a) assessing the degree of an impairment in memory consolidation in a human;    b) administering at least one member selected from the group consisting of 1-amphetamine and 1-methamphetamine to the human; and    c) determining the improvement in memory consolidation after administering the 1-amphetamine and 1-methamphetamine to the human.    
     
     
         17 . The method of  claim 16 , further including the step of comparing the impairment in memory consolidation in the human before administering the 1-amphetamine and 1-methamphetamine to the improvement in memory consolidation in the human after administering the 1-amphetamine and 1-methamphetamine.  
     
     
         18 . The method of  claim 16 , wherein memory consolidation is assessed and determined by a Rey Auditory Verbal Learning Test.  
     
     
         19 . The method of  claim 16 , wherein the 1-amphetamine and 1-methamphetamine is administered in a dose of at least about a 0.01 mg dose.  
     
     
         20 . The method of  claim 16 , wherein 1-amphetamine is administered, and wherein the 1-amphetamine is administered as a component of a composition that includes at least about 80 mole percent 1-amphetamine relative to a total amphetamine content of the composition.  
     
     
         21 . The method of  claim 16 , wherein 1-methamphetamine is administered, and wherein the 1-methamphetamine is administered as a component of a composition that includes at least about 80 mole percent 1-methamphetamine relative to a total methamphetamine content of the composition.  
     
     
         22 . The method of  claim 16 , wherein the 1-amphetamine and 1-methamphetamine is administered in a single dose.  
     
     
         23 . The method of  claim 16 , wherein the 1-amphetamine and 1-methamphetamine is administered in multiple doses.