Crystalline 1-methylcarbapenem derivatives

Abstract

This invention provides crystalline forms of a 1-methylcarbapenem derivative of formula (I) or of pharmaceutically acceptable salts thereof. The crystalline forms of the 1-methylcarbapenem derivative exhibit excellent antibiotic activity against various bacterial strains and sufficient stability for practical use.

What is claimed is:  
     
         1 . A 1-methylcarbapenem derivative of formula (I) or a pharmaceutically acceptable salt thereof in crystalline form:  
       
         
           
           
               
               
           
         
       
     
     
         2 . A 1-methylcarbapenem derivative of formula (I-1) in crystalline form:  
       
         
           
           
               
               
           
         
       
     
     
         3 . A 1-methylcarbapenem derivative of formula (I-2) in crystalline form:  
       
         
           
           
               
               
           
         
       
     
     
         4 . A 1-methylcarbapenem derivative of formula (I) in crystalline form:  
       
         
           
           
               
               
           
         
       
     
     
         5 . A 1-methylcarbapenem derivative of formula (I-3) in crystalline form:  
       
         
           
           
               
               
           
         
       
     
     
         6 . A pharmaceutical composition for the prevention or treatment of bacterial infections comprising a therapeutically effective amount of a 1-methylcarbapenem derivative of formula (I) or a pharmaceutically acceptable salt thereof in crystalline form as claimed in  claim 1  as an active ingredient together with a diluent or carrier therefor.  
     
     
         7 . A pharmaceutical composition for the prevention or treatment of bacterial infections comprising a therapeutically effective amount of a 1-methylcarbapenem derivative of formula (I-1) in crystalline form as claimed in  claim 2  as an active ingredient together with a diluent or carrier therefor.  
     
     
         8 . A pharmaceutical composition for the prevention or treatment of bacterial infections comprising a therapeutically effective amount of a 1-methylcarbapenem derivative of formula (I-2) in crystalline form as claimed in  claim 3  as an active ingredient together with a diluent or carrier therefor.  
     
     
         9 . A pharmaceutical composition for the prevention or treatment of bacterial infections comprising a therapeutically effective amount of a 1-methylcarbapenem derivative of formula (I) in crystalline form as claimed in  claim 4  as an active ingredient together with a diluent or carrier therefor.  
     
     
         10 . A pharmaceutical composition for the prevention or treatment of bacterial infections comprising a therapeutically effective amount of a 1-methylcarbapenem derivative of formula (I-3) in crystalline form as claimed in  claim 5  as an active ingredient together with a diluent or carrier therefor.  
     
     
         11 . A method for preventing or treating bacterial infections which comprises administering to a warm-blooded animal in need of such prevention or treatment a pharmacologically effective amount of a 1-methylcarbapenem derivative of formula (I) or a pharmaceutically acceptable salt thereof in crystalline form as claimed in  claim 1 .  
     
     
         12 . A method for preventing or treating bacterial infections which comprises administering to a warm-blooded animal in need of such prevention or treatment a pharmacologically effective amount of a 1-methylcarbapenem derivative of formula (I-1) in crystalline form as claimed in  claim 2 .  
     
     
         13 . A method for preventing or treating bacterial infections which comprises administering to a warm-blooded animal in need of such prevention or treatment a pharmacologically effective amount of a 1-methylcarbapenem derivative of formula (I-2) in crystalline form as claimed in  claim 3 .  
     
     
         14 . A method for preventing or treating bacterial infections which comprises administering to a warm-blooded animal in need of such prevention or treatment a pharmacologically effective amount of a 1-methylcarbapenem derivative of formula (I) in crystalline form as claimed in  claim 4 .  
     
     
         15 . A method for preventing or treating bacterial infections which comprises administering to a warm-blooded animal in need of such prevention or treatment a pharmacologically effective amount of a 1-methylcarbapenem derivative of formula (I-3) in crystalline form as claimed in  claim 5.