US2003229216A1PendingUtilityA1
Constitutively activated human G protein coupled receptors
Priority: Oct 13, 1998Filed: Apr 16, 2003Published: Dec 11, 2003
Est. expiryOct 13, 2018(expired)· nominal 20-yr term from priority
C07K 14/705A61K 38/00C07K 14/723G01N 33/566
56
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Claims
Abstract
The invention disclosed in this patent document relates to transmembrane receptors, more particularly to a human G protein-coupled receptor for which the endogenous ligand is unknown (“orphan GPCR receptors”), and most particularly to mutated (non-endogenous) versions of the human GPCRs for evidence of constitutive activity.
Claims
exact text as granted — not AI-modifiedWhat is claimed is:
1 . A cDNA encoding a non-endogenous, constitutively activated version of a human G protein-coupled receptor comprising hARE-3(F313K).
2 . A non-endogenous version of a human G protein-coupled receptor encoded by the cDNA of claim 1 .
3 . A Plasmid comprising a Vector and the cDNA of claim 1 .
4 . A Host Cell comprising the Plasmid of claim 3 .
5 . A cDNA encoding a non-endogenous, constitutively activated version of a human G protein-coupled receptor comprising hARE-4(V233K)
6 . A non-endogenous version of a human G protein-coupled receptor encoded by the cDNA of claim 5 .
7 . A Plasmid comprising a Vector and the cDNA of claim 5 .
8 . A Host Cell comprising the Plasmid of claim 7 .
9 . A cDNA encoding a non-endogenous, constitutively activated version of a human G protein-coupled receptor comprising hARE-5(A240K).
10 . A non-endogenous version of a human G protein-coupled receptor encoded by the cDNA of claim 9 .
11 . A Plasmid comprising a Vector and the cDNA of claim 5 .
12 . A Host Cell comprising the Plasmid of claim 11 .
13 . A cDNA encoding a non-endogenous, constitutively activated version of a human G protein-coupled receptor comprising hGPCR14(L257K).
14 . A non-endogenous version of a human G protein-coupled receptor encoded by the cDNA of claim 13 .
15 . A Plasmid comprising a Vector and the cDNA of claim 13 .
16 . A Host Cell comprising the Plasmid of claim 15 .
17 . A cDNA encoding a non-endogenous, constitutively activated version of a human G protein-coupled receptor comprising hGPCR27(C283K).
18 . A non-endogenous version of a human G protein-coupled receptor encoded by the cDNA of claim 17 .
19 . A Plasmid comprising a Vector and the cDNA of claim 17 .
20 . A Host Cell comprising the Plasmid of claim 19 .
21 . A cDNA encoding a non-endogenous, constitutively activated version of a human G protein-coupled receptor comprising hARE-1(E232K).
22 . A non-endogenous version of a human G protein-coupled receptor encoded by the cDNA of claim 21 .
23 . A Plasmid comprising a Vector and the cDNA of claim 21 .
24 . A Host Cell comprising the Plasmid of claim 23 .
25 . A cDNA encoding a non-endogenous, constitutively activated version of a human G protein-coupled receptor comprising hARE-2(G285K).
26 . A non-endogenous version of a human G protein-coupled receptor encoded by the cDNA of claim 25 .
27 . A Plasmid comprising a Vector and the cDNA of claim 25 .
28 . A Host Cell comprising the Plasmid of claim 27 .
29 . A cDNA encoding a non-endogenous, constitutively activated version of a human G protein-coupled receptor comprising hPPR1(L239K).
30 . A non-endogenous version of a human G protein-coupled receptor encoded by the cDNA of claim 29 .
31 . A Plasmid comprising a Vector and the cDNA of claim 29 .
32 . A Host Cell comprising the Plasmid of claim 31 .
33 . A cDNA encoding a non-endogenous, constitutively activated version of a human G protein-coupled receptor comprising hG2A(K232A).
34 . A non-endogenous version of a human G protein-coupled receptor encoded by the cDNA of claim 33 .
35 . A Plasmid comprising a Vector and the cDNA of claim 33 .
36 . A Host Cell comprising the Plasmid of claim 35 .
37 . A cDNA encoding a non-endogenous, constitutively activated version of a human G protein-coupled receptor comprising hRUP3(L224K).
38 . A non-endogenous version of a human G protein-coupled receptor encoded by the cDNA of claim 37 .
39 . A Plasmid comprising a Vector and the cDNA of claim 37 .
40 . A Host Cell comprising the Plasmid of claim 39 .
41 . A cDNA encoding a non-endogenous, constitutively activated version of a human G protein-coupled receptor comprising hRUP5(A236K).
42 . A non-endogenous version of a human G protein-coupled receptor encoded by the cDNA of claim 41 .
43 . A Plasmid comprising a Vector and the cDNA of claim 41 .
44 . A Host Cell comprising the Plasmid of claim 42 .
45 . A cDNA encoding a non-endogenous, constitutively activated version of a human G protein-coupled receptor comprising hRUP6(N267K)
46 . A non-endogenous version of a human G protein-coupled receptor encoded by the cDNA of claim 45 .
47 . A Plasmid comprising a Vector and the cDNA of claim 45 .
48 . A Host Cell comprising the Plasmid of claim 47 .
49 . A cDNA encoding a non-endogenous, constitutively activated version of a human G protein-coupled receptor comprising hRUP7(A302K).
50 . A non-endogenous version of a human G protein-coupled receptor encoded by the cDNA of claim 49 .
51 . A Plasmid comprising a Vector and the cDNA of claim 49 .
52 . A Host Cell comprising the Plasmid of claim 51 .
53 . A cDNA encoding a non-endogenous, constitutively activated version of a human G protein-coupled receptor comprising hCHN4(V236K).
54 . A non-endogenous version of a human G protein-coupled receptor encoded by the cDNA of claim 53 .
55 . A Plasmid comprising a Vector and the cDNA of claim 53 .
56 . A Host Cell comprising the Plasmid of claim 55 .
57 . A cDNA encoding a non-endogenous, constitutively activated version of a human G protein-coupled receptor comprising hMC4(A244K).
58 . A non-endogenous version of a human G protein-coupled receptor encoded by the cDNA of claim 57 .
59 . A Plasmid comprising a Vector and the cDNA of claim 57 .
60 . A Host Cell comprising the Plasmid of claim 60 .
61 . A cDNA encoding a non-endogenous, constitutively activated version of a human G protein-coupled receptor comprising hCHN3(S284K).
62 . A non-endogenous version of a human G protein-coupled receptor encoded by the cDNA of claim 61 .
63 . A Plasmid comprising a Vector and the cDNA of claim 61 .
64 . A Host Cell comprising the Plasmid of claim 63 .
65 . A cDNA encoding a non-endogenous, constitutively activated version of a human G protein-coupled receptor comprising hCHN6(L352K).
66 . A non-endogenous version of a human G protein-coupled receptor encoded by the cDNA of claim 65 .
67 . A Plasmid comprising a Vector and the cDNA of claim 65 .
68 . A Host Cell comprising the Plasmid of claim 67 .
69 . A cDNA encoding a non-endogenous, constitutively activated version of a human G protein-coupled receptor comprising hCHN8(N235K).
70 . A non-endogenous version of a human G protein-coupled receptor encoded by the cDNA of claim 69 .
71 . A Plasmid comprising a Vector and the cDNA of claim 69 .
72 . A Host Cell comprising the Plasmid of claim 71 .
73 . A cDNA encoding a non-endogenous, constitutively activated version of a human G protein-coupled receptor comprising hH9(F236K).
74 . A non-endogenous version of a human G protein-coupled receptor encoded by the cDNA of claim 73 .
75 . A Plasmid comprising a Vector and the cDNA of claim 73 .
76 . A Host Cell comprising the Plasmid of claim 74 .
77 . A cDNA encoding a non-endogenous, constitutively activated version of a human G protein-coupled AT1 receptor selected from the group consisting of: hAT1(F239K); hAT1(N111A); hAT1(AT2K255IC3); and hAT1(A243+).
78 . A non-endogenous version of a human G protein-coupled receptor encoded by a cDNA of claim 77 .
79 . A Plasmid comprising a Vector and the cDNA of claim 77 .
80 . A Host Cell comprising the Plasmid of claim 79.Join the waitlist — get patent alerts
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