Use of stilbene derivatives for dandruff treatment

Abstract

The present invention relates to the use of resveratrol and its derivatives as active principles in antidandruff formulations.

1 . Use in the cosmetic treatment of dandruff of resveratrol and its ethers, esters and hydroxylated, ethoxylated and glycosylated derivatives, of formula (I)  
       
         
           
           
               
               
           
         
       
       wherein: 
 R 1 , R 2 , R 3  are C 1 -C 36  alkyl groups, optionally substituted by OH groups and optionally comprising one or more double bonds; C 1 -C 36  acyl groups, optionally substituted by OH groups and optionally comprising one or more double bonds; a —(CH 2 —CH 2 —O) n —H group where n is an integer from 1 to 30; or a glycosidic residue; and R 4  is H or OH.  
 
     
     
         2 . Use as claimed in  claim 1 , wherein the resveratrol ether derivatives have formula (I), wherein at least one of R 1 , R 2 , R 3  is a C 1 -C 36  alkyl group, optionally substituted by OH groups and optionally comprising one or more double bonds, and the others can be H; and R 4  is H.  
     
     
         3 . Use as claimed in  claim 1 , wherein the resveratrol ester derivatives have formula (I), wherein at least one of R 1 , R 2 , R 3  is a C 1 -C 36  acyl group, optionally substituted by OH groups and optionally comprising one or more double bonds, and the others can be H; and R 4  is OH.  
     
     
         4 . Use as claimed in  claim 1 , wherein the resveratrol ethoxylated derivatives have formula (I), wherein at least one of R 1 , R 2 , R 3  is a —(CH 2 —CH 2 —O) n —H group where n is an integer from 1 to 30, and the others can be H; and R 4  is H.  
     
     
         5 . Use as claimed in  claim 1 , wherein resveratrol glycosylated derivatives have formula (I), wherein at least one of R 1 , R 2 , R 3  is a glycosidic residue, and the others can be H; and R 4  is H.  
     
     
         6 . Antidandruff preparations comprising resveratrol derivatives according to the claims  1 - 5  and a cosmetic acceptable carrier selected from the group consisting of a solution, an oil, a cream, a lotion, a gel and a powder and auxiliary agents selected from the group consisting of thickeners, emulsifiers, preservatives and fragrances, and having an acid pH between 3.5 and 5.0.  
     
     
         7 . Antidandruff preparations according to  claim 6  containing 0.01 to 30% w/w resveratrol or derivatives thereof, preferably 0.1 to 5% w/w.  
     
     
         8 . Antidandruff preparations, according to the claims  6  or  7  containing resveratrol derivatives, according to the claims  1 - 5 , in association with coal tar, pyrition and its derivatives, undecilenic acid and its derivatives and anti-fungine and anti-inflammatory compounds.