Cell membrane directed drugs

Abstract

Drugs in which peptides having affinity specific for phospholipids, preferably those which are contained in the constituents of lipid bilayers forming the surface layers of cells and of which the proportion in the outer part of each lipid bilayer increases when the cell is not normal, for example, in the case where it is damaged, denatured or activated, and biologically active substances bind to each other, deoxyribonucleic acid (DNA) which codes for the amino acid sequence of the drug in the case where the biologically active substance is a peptide, and processes for producing such drugs. The drugs and novel peptides are useful as preventives and therapeutics of diseases involving coagulopathy, inflammations and immune response.

1 . A DNA coding for a peptide comprising both a substance having affinity for a phospholipid and a biologically active substance, wherein said substance having affinity for a phospholipid has an amino acid sequence represented by the following formula: 
 (A1)n1-(A2)n2-(A3)n3    (provided that A1 is the amino acid sequence denoted by SEQ ID NO: 1 or 10; A2 and A3 are the amino acid sequences denoted by SEQ ID NOS: 2 and 3, respectively; n1, n2 and n3 which are the repeating numbers of A1, A2 and A3, respectively, are 0-5,1-5 and 0-5, respectively).    
     
     
         2 . The DNA according to  claim 1 , wherein n1 is 0 or 1, n2 is 1, 2 or 3, and n3 is 0 or 1.  
     
     
         3 . The DNA according to  claim 2 , wherein said substance having affinity for a phospholipid is represented by a formula selected from the group consisting of: 
 (A1)1-(A2)1-(A3)1,    (A2)1-(A3)1,    (A2)2-(A3)1,    (A2)3-(A3)1, and    (A2)2.    
     
     
         4 . The DNA according to  claim 3 , wherein said substance having affinity for a phospholipid is represented by a formula selected from the group consisting of: 
 (A2)2-(A3)1,    (A2)3-(A3)1, and    (A2)2.    
     
     
         5 . A DNA coding for a peptide comprising an amino acid sequence represented by a formula selected from the group consisting of: 
 (A2)n 2 -(A3)1 and    (A2)n 2      (provided that A2 is the amino acid sequence denoted by SEQ ID NO:2, A3 is the amino acid sequence denoted by SEQ ID NO: 3, and n2 is 2 or 3).    
     
     
         6 . The DNA according to  claim 5 , wherein said amino acid sequence is represented by a formula selected from the group consisting of: 
 (A2)2-(A3)1,    (A2)3-(A3)1, and    (A2)2.