US2003220480A1PendingUtilityA1

Cell-permeable peptide inhibitors of the JNK signal transduction pathway

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Priority: Oct 12, 1999Filed: Jan 15, 2003Published: Nov 27, 2003
Est. expiryOct 12, 2019(expired)· nominal 20-yr term from priority
Inventors:Christophe Bonny
A61P 37/04A61P 37/08A61P 39/00A61P 9/10A61P 31/18A61P 7/00A61P 37/00A61P 9/00A61P 37/02A61P 39/06A61P 43/00A61P 35/02A61P 35/00A61P 3/00A61P 25/18A61P 29/00A61P 11/16A61P 17/06A61P 17/16A61P 17/00A61P 19/02C07K 2319/10C07K 14/4703C07K 2319/00A61K 38/00
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Claims

Abstract

The invention provides cell-permeable peptides that bind to JNK proteins and inhibit JNK-mediated effects in JNK-expressing cells.

Claims

exact text as granted — not AI-modified
What is claimed is:  
     
         1 . A D-enantiomeric peptide comprising the amino acid sequence of SEQ ID NO: 8.  
     
     
         2 . The peptide of  claim 1 , wherein said peptide facilitates transport across a biological membrane.  
     
     
         3 . A D-enantiomeric peptide comprising the amino acid sequence of SEQ ID NO: 10.  
     
     
         4 . The peptide of  claim 3 , wherein said peptide facilitates transport across a biological membrane.  
     
     
         5 . A protein comprising a D-enantiomeric peptide comprising the amino acid sequence of SEQ ID NO: 8.  
     
     
         6 . A protein comprising a D-enantiomeric peptide comprising the amino acid sequence of SEQ ID NO: 8.  
     
     
         7 . A protein comprising a D-enantiomeric peptide consisting of the amino acid sequence of SEQ ID NO: 8.  
     
     
         8 . A protein comprising a D-enantiomeric peptide consisting of the amino acid sequence of SEQ ID NO: 10.

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