Progression elevated Gene-3 and uses thereof

Abstract

This invention provides a vector suitable for introduction into a cell, comprising: a) an inducible PEG-3 regulatory region; and b) a gene encoding a product that causes or may be induced to cause the death or inhibition of cancer cell growth. In addition, this invention further provides the above-described vectors, wherein the inducible PEG-3 regulatory region is a promoter. This invention further provides the above-described vectors, wherein the gene encodes an inducer of apoptosis. In addition, this invention provides the above-described vectors, wherein the gene is a tumor suppressor gene. In addition, this invention provides the above-described vectors, wherein the gene encodes a viral replication protein. This invention also provides the above-described vectors, wherein the gene encodes a product toxic to cells or an intermediate to a product toxic to cells. In addition, this invention provides the above-described vectors, wherein the gene encodes a product causing enhanced immune recognition of the cell. This invention further provides the above-described vectors, wherein the gene encodes a product causing the cell to express a specific antigen.

25 . A method of treating cancer in a subject, comprising: 
 a. administering the vector of claim  14  to the subject; and    b. administering gancyclovir or acyclovir to the subject.    
     
     
         26 . A method of treating cancer in a subject, comprising: 
 a. administering the vector of claim  24  to the subject; and    b. administering an antibody or a fragment of an antibody to the antigen of claim  24  to the subject.    
     
     
         27 . The method of  claim 26 , wherein the antibody is toxic or linked to a toxic substance.  
     
     
         28 . The method of  claim 26 , wherein the antibody is labeled and used for tumor imaging.  
     
     
         29 . The method of  claim 27 , wherein the antibody is radioactive.  
     
     
         30 . A pharmaceutical composition comprising the vector of claim  2  and a carrier.