US2003209291A1PendingUtilityA1
Products and methods
Priority: Jun 11, 1999Filed: Jun 2, 2003Published: Nov 13, 2003
Est. expiryJun 11, 2019(expired)· nominal 20-yr term from priority
C23C 22/68G21G 4/06A61N 5/1001A61N 2005/1019G21G 4/08
42
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Claims
Abstract
A method for the immobilisation of a radioactive anion on the surface of a metal substrate, said method comprising treating the substrate with an oxidising agent in the presence of a solution of a radioactive anion which forms an insoluble salt with ions of said metal. Preferably, a binding agent will also be present. Preferably, the metal is silver, the radioactive anion is 125 I − and the binding agent comprises bromide ions.
Claims
exact text as granted — not AI-modifiedWhat is claimed is:
1 . A method for the immobilisation of a radioisotope on the metal surface of a substrate, said method comprising treating the substrate with an oxidising agent in the presence of a source of a radioactive anion wherein the oxidising agent is capable of oxidising the metal to the corresponding metal ion, and the radioactive anion is capable of forming an insoluble salt with said metal cation.
2 . The method of claim 1 , wherein the metal is selected from the group consisting of silver, gold, copper and lead.
3 . The method of claim 2 , wherein the metal is silver.
4 . The method of claim 1 , wherein the radioactive anion comprises 125 I, 35 S or 32 P.
5 . The method of claim 1 , wherein the radioactive anion is selected from the group consisting of 125 I − , 131 I − , 123 I − , 35 S 2− , 35 SO 4 2− , 35 SO 3 2− , 125 IO 3 − , 131 IO 3 − , 123 IO 3 − , 51 CrO 4 2− , 32 PO 4 3− , H 32 PO 4 2− , H 2 32 PO 4 − and H 3 32 P 2 O 7 − .
6 . The method of claim 5 , wherein the radioactive anion is 125 I − .
7 . The method of claim 1 which further comprises adding a binding agent.
8 . The method of claim 7 , wherein the metal is silver and the radioactive anion is 125 I − .
9 . The method of claim 8 , wherein the binding agent comprises bromide or chloride ions.
10 . The method of claim 1 , wherein the oxidising agent is selected from the group consisting of sodium chlorite (NaClO 2 ), sodium chlorate (NaClO 3 ), sodium chromate (Na 2 CrO 4 ), hydrogen peroxide (H 2 O 2 ), potassium dichromate (K 2 Cr 2 O 7 ), potassium permanganate (KMnO 4 ), and potassium ferricyanide (K 3 Fe(CN) 6 ).
11 . The method of claim 10 , wherein the oxidising agent is potassium ferricyanide.
12 . The method of claim 11 which further comprises adding potassium ferrocyanide, to a molar ratio of Fe(CN) 6 3− :[Fe(CN) 6 4− of about 10:1 at the start of the oxidising reaction.
13 . The method of claim 1 , wherein the source of the radioactive anion comprises a solution or dispersion.
14 . The method of claim 1 , wherein the immobilisation takes place in a solution comprising an elevated concentration of a salt additive.
15 . The method of claim 14 , wherein the salt additive is NaCl, KCl, CsCl, LiCl, CaCl 2 , NaNO 3 or MgCl 2 .
16 . The method of claim 14 , wherein the concentration of the salt additive is in the range of about 0.01 molar to the saturation level of the added salt.
17 . A radioactive metal substrate prepared by the method as of claim 7 .
18 . A radioactive source for use in brachytherapy comprising a radioactive metal substrate prepared by the method of claim 1 .
19 . A radioactive source for use in brachytherapy comprising the radioactive metal substrate of claim 17 .
20 . The method of claim 1 wherein the source of the radioactive anion comprises two or more radioisotopes.Join the waitlist — get patent alerts
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