US2003203849A1PendingUtilityA1

Composition promoting lacrimal secretion

38
Priority: Dec 27, 1999Filed: Dec 8, 2000Published: Oct 30, 2003
Est. expiryDec 27, 2019(expired)· nominal 20-yr term from priority
Inventors:Hiromasa ArakiAtsufumi KawabataShuichi TanakaKenzo KawaiSachiyo NishimuraHiroyuki Nishikawa
A61P 43/00G02B 1/043A61K 38/4826A61P 27/02A61K 38/06A61L 27/227A61K 38/177A61K 38/482A61K 38/08
38
PatentIndex Score
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Cited by
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References
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Claims

Abstract

A composition for promoting lacrimal secretion which can be used safely and effectively in the lacrimal secretion promoting therapy, not in the conventional supplemental therapy of lacrimal fluid components is provided. The composition comprises a component which activates PAR-2. Also, a contact lens which retains and/or contains said composition for promoting lacrimal secretion is provided.

Claims

exact text as granted — not AI-modified
What is claimed is:  
     
         1 . A composition for promoting lacrimal secretion comprising a component which activates PAR-2.  
     
     
         2 . The composition for promoting lacrimal secretion according to  claim 1 , wherein the component is a peptide.  
     
     
         3 . The composition for promoting lacrimal secretion according to  claim 2 , wherein the peptide comprises a sequence selected from the group consisting of Ser-Leu-Ile-Gly-Arg-Leu-NH 2  (SEQ ID NO: 1), Ser-Leu-Ile-Gly-Arg-Leu-OH (SEQ ID NO: 2) and trans-cynnamoyl-Leu-Ile-Gly-Arg-Leu-ornithine-NH 2  (SEQ ID NO: 3).  
     
     
         4 . The composition for promoting lacrimal secretion according to  claim 1 , wherein the component is a protein.  
     
     
         5 . The composition for promoting lacrimal secretion according to  claim 4 , wherein the protein is trypsin and/or tryptase.  
     
     
         6 . The composition for promoting lacrimal secretion according to any one of claims  1 - 5 , wherein a substance which inhibits inactivation or degradation of the component is used together and/or is incorporated therein.  
     
     
         7 . The composition for promoting lacrimal secretion according to  claim 6 , wherein the substance is a peptidase inhibitor.  
     
     
         8 . The composition for promoting lacrimal secretion according to  claim 7 , wherein the peptidase inhibitor is amastatine.  
     
     
         9 . The composition for promoting lacrimal secretion according to any one of claims  1 - 8 , which is formulated into a DDS preparation.  
     
     
         10 . The composition for promoting lacrimal secretion according to any one of claims  1 - 9 , which is formulated into a percutaneously absorbing preparation.  
     
     
         11 . The composition for promoting lacrimal secretion according to any one of claims  1 - 9 , which is an ophthalmic composition.  
     
     
         12 . The composition for promoting lacrimal secretion according to  claim 11 , wherein the ophthalmic composition has a form of a washing solution, an eye drop, an ophthalmic ointment or an ophthalmic gel.  
     
     
         13 . The composition for promoting lacrimal secretion according to  claim 11 , wherein the ophthalmic composition has a form of an eye drop for contact lens, a preserving solution for contact lens or a washing solution for contact lens.  
     
     
         14 . A contact lens which retains and/or contains the composition for promoting lacrimal secretion of any one of claims  1 - 8 .  
     
     
         15 . The contact lens according to  claim 14  which retains and/or contains the composition for promoting lacrimal secretion of any one of claims  1 - 8  such that it is sustainedly released.  
     
     
         16 . An agent for treating or preventing an ocular disease, which comprises the composition for promoting lacrimal secretion of any one of claims  1 - 8 .  
     
     
         17  The. agent for treating or preventing an ocular disease according to  claim 16 , wherein the ocular disease is dry eye, ectocorneal desquamation, corneitis, corneal ulcer or conjunctivitis.

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