Active oxygen scavenger and cancer chemopreventer from Grifola

Abstract

The present invention relates to an active oxygen scavenging agent and a cancer chemopreventing agent both comprising a dried Grifola, a dry Grifola powder and/or a Grifola extract, and to a food or animal feed comprising the active oxygen scavenging agent or the cancer chemopreventing agent.

What is claimed is:  
     
         1 . An active oxygen scavenging agent comprising a dried Grifola, a dry Grifola powder and/or a Grifola extract.  
     
     
         2 . The active oxygen scavenging agent of  claim 1 , wherein the dried Grifola is produced by drying a fresh Grifola at a temperature ranging from 50 to 90° C.  
     
     
         3 . The active oxygen scavenging agent of  claim 1 , wherein the dry Grifola powder is produced by: drying a fresh Grifola at a temperature ranging from 50 to 90° C. to give a dried Grifola; and then grinding the dried Grifola into powder using a milling apparatus.  
     
     
         4 . The active oxygen scavenging agent of  claim 1 , wherein the Grifola extract is produced by extracting a fresh Grifola, a dried Grifola and/or a dry Grifola powder with water or hot water.  
     
     
         5 . The active oxygen scavenging agent of  claim 1 , wherein the Grifola extract is produced by: extracting a fresh Grifola, a dried Grifola and/or a dry Grifola powder with water or hot water to give an extract; adding an alcohol to the extract; leaving the resultant solution to stand; and then removing matters floating on and/or in the solution and/or adhered to the wall surface of the vessel in which the solution is contained, from the solution.  
     
     
         6 . The active oxygen scavenging agent of  claim 1 , wherein the Grifola extract is produced by: extracting a fresh Grifola, a dried Grifola and/or a dry Grifola powder with water or hot water to give an extract; adding an alcohol to the extract; leaving the resultant solution to stand; removing matters floating on and/or in the solution and/or adhered to the wall surface of the vessel in which the solution is contained, from the solution; removing the alcohol from the solution; and then drying the resultant solution.  
     
     
         7 . The active oxygen scavenging agent of any one of  claims 1  to  6 , wherein the active oxygen to be scavenged with the scavenging agent is a hydroxyl radical and/or a superoxide anion radical.  
     
     
         8 . A food or animal feed with active oxygen scavenging activity, comprising the active oxygen scavenging agent of any one of  claims 1  to  7 .  
     
     
         9 . A cancer chemopreventing agent comprising a dried Grifola, a dry Grifola powder and/or a Grifola extract.  
     
     
         10 . The cancer chemopreventing agent of  claim 9 , wherein the target cancer to be treated by the cancer chemopreventing agent is gastrointestinal cancer.  
     
     
         11 . The cancer chemopreventing agent of  claim 9 , wherein the target cancer to be treated by the cancer chemopreventing agent is colorectal cancer.  
     
     
         12 . The cancer chemopreventing agent of  claim 9 , wherein the dried Grifola is produced by drying a fresh Grifola at a temperature ranging from 50 to 90° C.  
     
     
         13 . The cancer chemopreventing agent of  claim 9 , wherein the dry Grifola powder is produced by: drying a fresh Grifola at a temperature ranging from 50 to 90° C. to give a dried Grifola; and then grinding the dried Grifola into powder using a milling apparatus.  
     
     
         14 . The cancer chemopreventing agent of any one of  claims 9  to  11 , wherein the Grifola extract is produced by extracting a fresh Grifola, a dried Grifola and/or a dry Grifola powder with water or hot, water.  
     
     
         15 . The cancer chemopreventing agent of any one of  claims 9  to  11 , wherein the Grifola extract is produced by: extracting a fresh Grifola, a dried Grifola and/or a dry Grifola powder with water or hot water to give an extract; adding an alcohol to the extract; leaving the resultant solution to stand; removing matters floating on and/or in the solution and/or adhered to the wall surface of the vessel in which the solution is contained, from the solution; removing the alcohol from the solution; and then drying the resultant solution.  
     
     
         16 . A process for producing a cancer chemopreventing agent, comprising: 
 mixing a water-soluble excipient with a Grifola extract produced by extracting a fresh Grifola, a dried Grifola and/or a dry Grifola powder with water or hot water; and then spray-drying the resultant mixture.    
     
     
         17 . A process for producing a cancer chemopreventing agent comprising: 
 mixing a water-soluble excipient with a Grifola extract produced by extracting a fresh Grifola, a dried Grifola and/or a dry Grifola powder with water or hot water to give an extract, adding an alcohol to the extract, leaving the resultant solution to stand, and then removing matters floating on and/or in the solution and/or adhered to the wall surface of the vessel in which the solution is contained from the solution; and then spray-drying the resultant mixture.    
     
     
         18 . A food or animal feed for the chemoprevention of cancer, comprising the cancer chemopreventing agent of any one of  claims 9  to  17 .