US2003198989A1PendingUtilityA1
Nucleic acid ligands
Est. expiryJun 11, 2010(expired)· nominal 20-yr term from priority
C12Q 1/70C12N 9/1276A61K 47/549G01N 2333/9726G01N 33/76G01N 2333/62G01N 33/56988G01N 2333/8125G01N 33/532G01N 2333/163G01N 2333/966C12N 15/1048G01N 2333/976G01N 2333/503C40B 40/00C12Q 1/6811C12Q 1/6804C07H 19/10F02B 2075/027G01N 2333/575C07H 21/00C12N 2310/322C07K 14/001G01N 2333/16G01N 33/68G01N 2333/96433G01N 2333/96486C12N 2310/13C12N 15/115C07H 19/06C12Q 1/37C12N 2310/53G01N 2333/974B82Y 5/00G01N 33/535G01N 33/531G01N 2333/96436G01N 2333/96455A61K 47/547G01N 33/6842A61P 43/00
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Claims
Abstract
This invention comprises nucleic acid ligand for use as a diagnostic reagent for detecting the presence or absence of a target molecule in a sample, and a diagnostic reagent to measure the amount of a target molecule in a sample. In a preferred embodiment the nucleic acid ligands are identified by the method of the invention referred to as the Systematic Evolution of Ligands by EXponential enrichment (SELEX), wherein a candidate mixture of nucleic acids are iteratively enriched in high affinity nucleic acids and amplified by further partitioning.
Claims
exact text as granted — not AI-modified1 . A diagnostic composition comprising a nucleic acid ligand.
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