US2003195346A1PendingUtilityA1
Secreted protein HEMCM42
Est. expiryMay 30, 2017(expired)· nominal 20-yr term from priority
Inventors:Steven RubenCraig RosenKenneth CarterPatrick J. DillonGregory EndressGuo-Liang YuJian NiPing Feng
A61K 38/00C07K 14/47C07K 14/525G01N 2500/04
59
PatentIndex Score
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Claims
Abstract
The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
Claims
exact text as granted — not AI-modifiedWhat is claimed is:
1 . An isolated protein comprising amino acid residues 30 to 113 of SEQ ID NO: 59.
2 . The isolated protein of claim 1 which comprises amino acid residues 2 to 113 of SEQ ID NO: 59.
3 . The isolated protein of claim 1 which comprises amino acid residues 1 to 113 of SEQ ID NO: 59.
4 . The protein of claim 1 which comprises a heterologous polypeptide sequence.
5 . A composition comprising the protein of claim 1 and a pharmaceutically acceptable carrier.
6 . An isolated protein produced by the method comprising:
(a) expressing the protein of claim 1 by a cell; and (b) recovering said protein.
7 . An isolated protein comprising the amino acid sequence of the secreted portion of the polypeptide encoded by the HEMCM42 cDNA contained in ATCC Deposit Number 209075.
8 . The isolated protein of claim 7 which comprises the amino acid sequence of the complete polypeptide encoded by the BEMCM42 cDNA contained in ATCC Deposit Number 209075, excepting the N-terminal methionine.
9 . The isolated protein of claim 7 which comprises the amino acid sequence of the complete polypeptide encoded by the HEMCM42 cDNA contained in ATCC Deposit Number 209075.
10 . The protein of claim 7 which comprises a heterologous polypeptide sequence.
11 . A composition comprising the protein of claim 7 and a pharmaceutically acceptable carrier.
12 . An isolated protein produced by the method comprising:
(a) expressing the protein of claim 7 by a cell; and (b) recovering said protein.
13 . An isolated protein comprising a polypeptide sequence which is at least 90% identical to amino acid residues 30 to 113 of SEQ ID NO: 59.
14 . The isolated protein of claim 13 , wherein said polypeptide sequence is at least 95% identical to amino acid residues 30 to 113 of SEQ ID NO: 59.
15 . The protein of claim 13 which comprises a heterologous polypeptide sequence.
16 . A composition comprising the protein of claim 13 and a pharmaceutically acceptable carrier.
17 . An isolated protein produced by the method comprising:
(a) expressing the protein of claim 13 by a cell; and (b) recovering said protein.
18 . An isolated protein comprising a polypeptide sequence which is at least 90% identical to amino acid residues 1 to 113 of SEQ ID NO: 59.
19 . The isolated protein of claim 18 , wherein said polypeptide sequence is at least 95% identical to amino acid residues 1 to 113 of SEQ ID NO: 59.
20 . The protein of claim 18 which comprises a heterologous polypeptide sequence.
21 . A composition comprising the protein of claim 18 and a pharmaceutically acceptable carrier.
22 . An isolated protein produced by the method comprising:
(a) expressing the protein of claim 18 by a cell; and (b) recovering said protein.
23 . An isolated protein comprising a polypeptide sequence which is at least 90% identical to the secreted portion of the polypeptide encoded by the HEMCM42 cDNA contained in ATCC Deposit Number 209075.
24 . The isolated protein of claim 23 , wherein said polypeptide sequence is at least 95% identical to the secreted portion of the polypeptide encoded by the HEMCM42 cDNA contained in ATCC Deposit Number 209075.
25 . The protein of claim 23 which comprises a heterologous polypeptide sequence.
26 . A composition comprising the protein of claim 23 and a pharmaceutically acceptable carrier.
27 . An isolated protein produced by the method comprising:
(a) expressing the protein of claim 23 by a cell; and (b) recovering said protein.
28 . An isolated protein comprising a polypeptide sequence which is at least 90% identical to the complete polypeptide encoded by the HEMCM42 cDNA contained in ATCC Deposit Number 209075.
29 . The isolated protein of claim 28 , wherein said polypeptide sequence is at least 95% identical to the complete polypeptide encoded by the HEMCM42 cDNA contained in ATCC Deposit Number 209075.
30 . The protein of claim 28 which comprises a heterologous polypeptide sequence.
31 . A composition comprising the protein of claim 28 and a pharmaceutically acceptable carrier.
32 . An isolated protein produced by the method comprising:
(a) expressing the protein of claim 28 by a cell; and (b) recovering said protein.
33 . An isolated protein comprising at least 30 contiguous amino acid residues of amino acid residues 30 to 113 of SEQ ID NO: 59.
34 . The isolated protein of claim 33 which comprises at least 50 contiguous amino acid residues of amino acid residues 30 to 113 of SEQ ID NO: 59.
35 . The protein of claim 33 which comprises a heterologous polypeptide sequence.
36 . A composition comprising the protein of claim 33 and a pharmaceutically acceptable carrier.
37 . An isolated protein produced by the method comprising:
(a) expressing the protein of claim 33 by a cell; and (b) recovering said protein.
38 . An isolated protein comprising at least 30 contiguous amino acid residues of the secreted portion of the polypeptide encoded by the HEMCM42 cDNA contained in ATCC Deposit Number 209075.
39 . The isolated protein of claim 38 comprising at least 50 contiguous amino acid residues of the secreted portion of the polypeptide encoded by the HEMCM42 cDNA contained in ATCC Deposit Number 209075.
40 . The protein of claim 38 which comprises a heterologous polypeptide sequence.
41 . A composition comprising the protein of claim 38 and pharmaceutically acceptable carrier.
42 . An isolated protein produced by the method comprising:
(a) expressing the protein of claim 38 by a cell; and (b) recovering said protein.
43 . An isolated protein comprising at least 30 contiguous amino acid residues of amino acid residues 1 to 113 of SEQ ID NO: 59.
44 . The isolated protein of claim 43 comprising at least 50 contiguous amino acid residues of amino acid residues 1 to 113 of SEQ ID NO: 59.
45 . The protein of claim 43 which comprises a heterologous polypeptide sequence.
46 . A composition comprising the protein of claim 43 and a pharmaceutically acceptable carrier.
47 . An isolated protein produced by the method comprising:
(a) expressing the protein of claim 43 by a cell; and (b) recovering said protein.
48 . An isolated protein comprising at least 30 contiguous amino acid residues of the complete polypeptide encoded by the HEMCM42 cDNA contained in ATCC Deposit Number 209075.
49 . The isolated protein of claim 48 comprising at least 50 contiguous amino acid residues of the complete polypeptide encoded by the HEMCM42 cDNA contained in ATCC Deposit Number 209075.
50 . The protein of claim 48 which comprises a heterologous polypeptide sequence.
51 . A composition comprising the protein of claim 48 and pharmaceutically acceptable carrier.
52 . An isolated protein produced by the method comprising:
(a) expressing the protein of claim 48 by a cell; and (b) recovering said protein.Join the waitlist — get patent alerts
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