US2003191292A1PendingUtilityA1

Filtration

61
Assignee: OCTAPHARMA AG A CORP OF SWITZEPriority: Jun 23, 1994Filed: Nov 26, 2002Published: Oct 9, 2003
Est. expiryJun 23, 2014(expired)· nominal 20-yr term from priority
Inventors:Stefan Winge
C07K 14/76C07K 1/34C07K 14/755C12N 9/644C12Y 304/21022C07K 14/8128C07K 14/4717A61K 38/37C12N 7/02C07K 14/47A61K 38/39A61K 38/38A61K 38/36
61
PatentIndex Score
0
Cited by
0
References
0
Claims

Abstract

Filtration methods comprise virus-filtering a solution containing a least one macromolecule. The total salt content of the solution for virus-filtering is within the range of from about 0.2 M up to saturation with the salt. Salts that can be used in the filtering methods include sodium chloride, potassium chloride, sodium acetate, sodium citrate, sodium phosphate, potassium dyhydrophosphate and combinations thereof.

Claims

exact text as granted — not AI-modified
1 . A method of virus-filtering a solution containing at least one macromolecule, characterized in that the total salt content of the solution lies within the range of from about 0.2 M up to saturation of the solution with the salt concerned.  
     
     
         2 . A method according to  claim 1 , characterized in that the total salt content of the solution lies within the range of from 0.4 up to 2.5 M.  
     
     
         3 . A method according to  claim 2 , characterized in that the total salt content of the solution lies within the range of from 0.6 up to 2.0 M.  
     
     
         4 . A method according to any previous claim, characterized in that the salt is selected from the group consisting of sodium chloride, potassium chloride, sodium acetate and sodium citrate and combinations thereof.  
     
     
         5 . A method according to any previous claim, characterized in that the macromolecule is selected from the group consisting of proteins, polysaccharides and polypeptides and combinations thereof.  
     
     
         6 . A method according to  claim 5 , characterized in that the macromolecule is factor IX.  
     
     
         7 . A method according to  claim 5 , characterized in that the macromolecule is gammaglobulin.  
     
     
         8 . A method according to  claim 5 , characterized in that the macromolecule is albumin.  
     
     
         9 . A method according to  claim 5 , characterized in that the macromolecule is antithrombin III.  
     
     
         10 . A method according to  claim 5 , characterized in that the macromolecule is a deletion derivative of recombinant factor VIII.  
     
     
         11 . A method according to any previous claim, characterized in that the virus-filtering process is carried out in accordance with the “dead-end” filtering technique.  
     
     
         12 . A method according to any previous claim, characterized in that the virus-filtering process reduces the content of non-enveloped viruses by at least 4 logs.

Join the waitlist — get patent alerts

Track US2003191292A1 — get alerts on status changes and closely related new filings.

We store only your email — no account needed. See our privacy policy.