US2003191085A1PendingUtilityA1

Topical delivery of vaccines

Priority: May 22, 2000Filed: May 13, 2003Published: Oct 9, 2003

Est. expiryMay 22, 2020(expired)· nominal 20-yr term from priority

Inventors:John Mikszta John Brittingham Jason B. Alarcon Ronald J. Pettis John Dekker

A61K 9/0021A61M 2037/0046A61M 37/00A61B 17/205A61M 2037/0061A61M 37/0015

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Claims

Abstract

The present invention provides improved methods for delivery of substances into the skin. It has been discovered that delivery of substances such as nucleic acids, amino acids, amino acid derivatives, peptides and polypeptides simultaneously with abrasion of the skin enhances delivery and the biological response as compared to application of the substance to previously abraded skin.

Claims

exact text as granted — not AI-modified

What is claimed is:  
     
         1 . A method for the targeted delivery of a vaccine to the epidermal tissue of skin to enhance the immune response comprising simultaneously disrupting the stratum corneum and delivering the vaccine to the epidermal tissue of the skin.  
     
     
         2 . The method of  claim 1  wherein the vaccine is a DNA vaccine.

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