US2003188324A1PendingUtilityA1

P300 transgenic animal

42
Priority: Jul 14, 2000Filed: Jul 13, 2001Published: Oct 2, 2003
Est. expiryJul 14, 2020(expired)· nominal 20-yr term from priority
Inventors:Koji HasegawaYosuke KawaseHiroshi Suzuki
A01K 2227/105C07K 14/4702A01K 2217/00A01K 2207/15A61P 9/04A01K 2267/0375A01K 67/0275A01K 2217/05C12N 2830/008C12N 15/8509A01K 2267/03A01K 67/0278
42
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Claims

Abstract

The present invention relates to a transgenic animal wherein DNA encoding p300 and a promoter exerting its activity in myocardial cells are introduced, and a screening method using the same.

Claims

exact text as granted — not AI-modified
1 . A transgenic animal wherein DNA encoding p300 and a promoter exerting its activity in myocardial cells are introduced.  
     
     
         2 . The transgenic animal according to  claim 1 , wherein the promoter exerting its activity in myocardial cells is α-myosin heavy chain promoter.  
     
     
         3 . A method of screening a substance having therapeutic activity for heart failure, the method comprising the steps of: 
 (1) administering a test substance to a transgenic animal according to  claim 1  or  2 ; and    (2) confirming whether or not cardiac hypertrophy is suppressed in the transgenic animal.    
     
     
         4 . A substance obtained by a screening method of  claim 3 .  
     
     
         5 . A therapeutic agent for heart failure containing as an active component a substance obtained by a screening method of  claim 3.

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