Algorithmic design of peptides for binding and/or modulation of the functions of receptors and/or other proteins

Abstract

Methods of synthesizing a peptide or peptide-like molecule to a polypeptide or protein target based on mode-matching each member of a set of peptide constituents of the peptide or peptide-like molecule to peptide constituents of the target polypeptide or protein target.

What is claimed is:  
     
         1 . An isolated peptide having the amino acid sequence of any member selected from the group consisting of SEQ ID NO: 1 through SEQ ID NO: 33.  
     
     
         2 . A complex comprising an isolated peptide having the amino acid sequence of any member of the group consisting of SEQ ID NO: 1 through SEQ ID NO: 33, and a polypeptide.  
     
     
         3 . The complex of  claim 2 , wherein said polypeptide is a D 2 DA receptor.  
     
     
         4 . The complex of  claim 2 , wherein said polypeptide is an NGF receptor.  
     
     
         5 . The complex of  claim 2 , wherein said polypeptide is a muscarinic M1 receptor.  
     
     
         6 . An isolated peptide having the amino acid sequence of any member selected from the group consisting of SEQ ID NO: 34 through SEQ ID NO: 93.  
     
     
         7 . A complex comprising an isolated peptide having the amino acid sequence of any member of the group consisting of SEQ ID NO: 34 through SEQ ID NO: 93, and a polypeptide.  
     
     
         8 . The complex of  claim 7 , wherein said polypeptide consists essentially of the calcitonin receptor.