US2003176434A1PendingUtilityA1
Compounds and methods for promoting smoking cessation
Est. expiryNov 8, 2020(expired)· nominal 20-yr term from priority
Inventors:F. Ivy Carroll
A61P 43/00A61P 25/18A61P 25/08A61P 25/28A61P 25/34A61P 3/04A61P 25/24A61P 25/22A61P 25/00A61P 25/16A61P 25/04A61K 31/4439C07D 487/22A61P 1/04A61K 31/44
52
PatentIndex Score
0
Cited by
0
References
0
Claims
Abstract
Compounds and methods for promoting smoking cessation. The compounds may be used to treat a variety of other conditions and disease states.
Claims
exact text as granted — not AI-modified1 . A method of training a smoker to quit smoking, comprising administering to a smoker in need thereof an effective amount of a compound represented by formula (I):
wherein
A 1 and A 2 are each, independently, H, —OH, —N(R)C(═NR)N(R) 2 , or —N(R) 2 ;
or
A 1 and A 2 together form ═O, ═NOR, ═NR, —O—NR—, —NR—O—, or —NR—NR—;
each Q is, independently, C—X or N, with the proviso that at least one Q is N and at least one Q is C—X;
each X is, independently, H, halogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, —OH, —OR, —CH 2 —CO 2 R, —CO—R, —CO 2 R, —N(R) 2 , —NR—CO—R, —CO—N(R) 2 , —NRCO 2 R, —SO 3 CF 3 , —NO 2 , —N 3 , —CF 3 , —CH═CHY, or —CN;
Y is a halogen; and
each R is, independently, H, alkyl, alkenyl, alkynyl, aryl, or aralkyl;
or a pharmaceutically acceptable salt thereof.
2 . The method of claim 1 , wherein A, and A 2 are each, independently, H, —OH, —N(R)C(═NR)N(R) 2 , or —N(R) 2 .
3 . The method of claim 1 , wherein A, and A 2 together form ═O, ═NOR, ═NR, —O—NR—, —NR—O—, or —NR—NR—.
4 . The method of claim 1 , wherein one of A 1 and A 2 is —NH 2 and the other is H.
5 . The method of claim 1 , wherein A 1 and A 2 together form ═NOH or ═NOCH 3 .
6 . The method of claim 1 , wherein one Q is N.
7 . The method of claim 1 , wherein each X is independently selected from the group consisting of H, F, Cl, Br, I, CH 3 , OH, NH 2 , (CH 3 ) 2 N, NHAc, CF 3 SO 3 , unsubstituted phenyl, phenyl substituted with a substituent selected from the group consisting of nitro and methoxy.
8 . The method of claim 1 , wherein R is H, alkyl or benzyl.
9 . The method of claim 1 , wherein at least one X is aryl.
10 . The method of claim 9 , wherein said aryl is unsubstituted phenyl or phenyl substituted with one or more substituents selected from the group consisting of halogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, —OH, —OR, —CH 2 —CO 2 R, —CO—R, —CO 2 R, —N(R) 2 , —NR—CO—R, —CO—N(R) 2 , —NRCO 2 R, —SO 3 CF 3 , —NO 2 , —N 3 , —CF 3 , —CH═CHY and —CN.
11 . The method of claim 1 , wherein the compound is represented by formula (Ia):
wherein
A 1 and A 2 are as defined in claim 1;
X 1 , X 2 , X 3 and X 4 are each, independently, H, halogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, —OH, —OR, —CH 2 —CO 2 R, —CO—R, —CO 2 R, —N(R) 2 , —NR—CO—R, —CO—N(R) 2 , —NRCO 2 R, —SO 3 CF 3 , —NO 2 , —N 3 , —CF 3 , —CH═CHY, or —CN;
Y is as defined in claim 1; and
R is as defined in claim 1 .
12 . The method of claim 1 , wherein the compound is represented by formula (Ib):
wherein
A 1 and A 2 are as defined in claim 1;
X 1 , X 3 and X 4 are each, independently, H, halogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, —OH, —OR, —CH 2 —CO 2 R, —CO—R, —CO 2 R, —N(R) 2 , —NR—CO—R, —CO—N(R) 2 , —NRCO 2 R, SO 3 CF 3 , —NO 2 , —N 3 , —CF 3 , —CH═CHY, or —CN;
Y is as defined in claim 1; and
R is as defined in claim 1 .
13 . The method of claim 1 , wherein said alkyl group in the definition of R is represented by the formula —(CH 2 ) n —Y, wherein Y is a halogen and n is an integer from 1 to 8.
14 . A method of training a smoker to quit smoking, comprising administering to a smoker in need thereof an effective amount of a compound represented by formula (II):
wherein
A 3 is —R, —N(R) 2 , —C(═NR)N(R) 2 or —OR;
each Q is, independently, C—X or N, with the proviso that at least one Q is N and at least one Q is C—X;
each X is, independently, H, halogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, —OH, —OR, —CH 2 —CO 2 R, —CO—R, —CO 2 R, —N(R) 2 , —NR—CO—R, —CO—N(R) 2 , —NRCO 2 R, —SO 3 CF 3 , —NO 2 , —N 3 , —CF 3 , —CH═CHY, or —CN;
Y is a halogen; and
each R is, independently, H, alkyl, alkenyl, alkynyl, aryl, or aralkyl;
or a pharmaceutically acceptable salt thereof.
15 . The method of claim 14 , wherein A 3 is H or alkyl.
16 . The method of claim 14 , wherein A 3 is H.
17 . The method of claim 14 , wherein one Q is N.
18 . The method of claim 14 , wherein each X is independently selected from the group consisting of H, F, Cl, Br, I, CH 3 , OH, NH 2 , (CH 3 ) 2 N, NHAc, CF 3 SO 3 , unsubstituted phenyl, phenyl substituted with a substituent selected from the group consisting of nitro and methoxy.
19 . The method of claim 14 , wherein R is H, alkyl or benzyl.
20 . The method of claim 14 , wherein at least one X is aryl.
21 . The method of claim 20 , wherein said aryl is unsubstituted phenyl or phenyl substituted with one or more substituents selected from the group consisting of halogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, —OH, —OR, —CH 2 —CO 2 R, —CO—R, —CO 2 R, —N(R) 2 , —NR—CO—R, —CO—N(R) 2 , —NRCO 2 R, —SO 3 CF 3 , —NO 2 , —N 3 , —CF 3 , —CH═CHY and —CN.
22 . The method of claim 14 , wherein the compound is represented by formula (IIa):
wherein
A 3 is as defined in claim 14;
X 1 , X 2 , X 3 and X 4 are each, independently, H, halogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, —OH, —OR, —CH 2 —CO 2 R, —CO—R, —CO 2 R, —N(R) 2 , —NR—CO—R, —CO—N(R) 2 , —NRCO 2 R, —SO 3 CF 3 , —NO 2 , —N 3 , —CF 3 , —CH═CHY, or —CN;
Y is as defined in claim 14; and
R is as defined in claim 14 .
23 . The-method of claim 14 , wherein the-com-pound is represented by formula (IIb):
wherein
A 3 is as defined in claim 14;
X 1 , X 2 , X 3 and X 4 are each, independently, H, halogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, —OH, —OR, —CH 2 —CO 2 R, —CO—R, —CO 2 R, —N(R) 2 , —NR—CO—R, —CO—N(R) 2 , —NRCO 2 R, —SO 3 CF 3 , —NO 2 , —N 3 , —CF 3 , —CH═CHY, or —CN;
each S is, independently, halogen, alkyl, alkenyl, alkynyl, phenyl, aralkyl, —OH, —OR, —CH 2 —CO 2 R, —CO—R, —CO 2 R, —N(R) 2 , —NR—CO—R, —CO—N(R) 2 , —NRCO 2 R, —SO 3 CF 3 , —NO 2 , —N 3 , —CF 3 , —CH═CHY, or —CN, or
two S, taken together with the phenyl group to which they are bonded, form a 2-naphthyl group;
Y is a halogen; and
c is 0, 1, 2, 3, 4 or 5.
24 . The method of claim 14 , wherein said alkyl group in the definition of R is represented by the formula —(CH 2 ) n —Y, wherein Y is a halogen and n is an integer from 1 to 8.
25 . A method of training a smoker to quit smoking, comprising administering to a smoker in need thereof an effective amount of a compound represented by formula (III):
wherein
Z is —(CH 2 ) m —, —O—, —NR—, —(CH 2 ) m —O—, —O—(CH 2 ) m —, —(CH 2 ) m N(R)—, —N(R)(CH 2 ) m —, —C(═NR)—, —(CH 2 ) m S—, —(CH 2 ) m CH═CH—, or —(CH 2 ) m C≡C—;
m is 1, 2, 3 or 4;
each Q is, independently, C—X or N, with the proviso that at least one Q is N and at least one Q is C—X;
each X is, independently, H, halogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, —OH, —OR, —CH 2 —CO 2 R, —CO—R, —CO 2 R, —N(R) 2 , —NR—CO—R, —CO—N(R) 2 , —NRCO 2 R, —SO 3 CF 3 , —NO 2 , —N 3 , —CF 3 , —CH═CHY, or —CN;
Y is a halogen; and
each R is, independently, H, alkyl, alkenyl, alkynyl, aryl, or aralkyl;
or a pharmaceutically acceptable salt thereof.
26 . The method of claim 25 , wherein Z is —CH 2 —.
27 . The method of claim 25 , wherein one Q is N.
28 . The method of claim 25 , wherein each X is independently selected from the group consisting of H, F, Cl, Br, I, CH 3 , OH, NH 2 , (CH 3 ) 2 N, NHAc, CF 3 SO 3 , unsubstituted phenyl, phenyl substituted with a substituent selected from the group consisting of nitro and methoxy.
29 . The method of claim 25 , wherein at least one X is aryl.
30 . The method of claim 25 , wherein said aryl is unsubstituted phenyl or phenyl substituted with one or more substituents selected from the group consisting of halogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, —OH, —OR, —CH 2 —CO 2 R, —CO—R, —CO 2 R, —N(R) 2 , —NR—CO—R, —CO—N(R) 2 , —NRCO 2 R, —SO 3 CF 3 , —NO 2 , —N 3 , —CF 3 , —CH═CHY and —CN.
31 . The method of claim 25 , wherein the compound is represented by (IIa):
wherein
Z is as defined in claim 25;
X 1 , X 2 and X 3 are each, independently, H, halogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, —OH, —OR, —CH 2 —CO 2 R, —CO—R, —CO 2 R, —N(R) 2 , —NR—CO—R, —CO—N(R) 2 , —NRCO 2 R, —SO 3 CF 3 , —NO 2 , —N 3 , —CF 3 , —CH═CHY, or —CN;
Y is a halogen; and
R is as defined in claim 25 .
32 . The method of claim 25 , wherein the compound is represented by formula (IIIb):
wherein
Z is as defined in claim 25;
X 1 , X 2 and X 3 are each, independently, H, halogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, —OH, —OR, —CH 2 —CO 2 R, —CO—R, —CO 2 R, —N(R) 2 , —NR—CO—R, —CO—N(R) 2 , —NRCO 2 R, —SO 3 CF 3 , —NO 2 , —N 3 , —CF 3 , —CH═CHY, or —CN;
Y is a halogen; and
R is as defined in claim 25 .
33 . The method of claim 25 , wherein said alkyl group in the definition of R is represented by the formula —(CH 2 ) n —Y, wherein Y is a halogen and n is an integer from 1 to 8.
34 . A compound represented by formula (I):
wherein
A 1 and A 2 are each, independently, H, —OH, —N(R)C(═NR)N(R) 2 , or —N(R) 2 ;
or
A 1 and A 2 together form ═O, ═NOR, ═NR, —O—NR—, —NR—O—, or —NR—NR—;
each Q is, independently, C—X or N, with the proviso that at least one Q is N and at least one Q is C—X;
each X is, independently, H, halogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, —OH, —OR, —CH 2 —CO 2 R, —CO—R, —CO 2 R, —N(R) 2 , —NR—CO—R, —CO—N(R) 2 , —NRCO 2 R, —SO 3 CF 3 , —NO 2 , —N 3 , —CF 3 , —CH═CHY, or —CN;
Y is a halogen; and
each R is, independently, H, alkyl, alkenyl, alkynyl, aryl, or aralkyl;
or a pharmaceutically acceptable salt thereof.
35 . The compound of claim 34 , wherein A 1 and A 2 are each, independently, H, —OH, —N(R)C(═NR)N(R) 2 , or —N(R) 2 .
36 . The compound of claim 34 , wherein A, and A 2 together form ═O, ═NOR, ═NR, —O—NR—, —NR—O—, or —NR—NR—.
37 . The compound of claim 34 , wherein one of A 1 and A 2 is —NH 2 and the other is H.
38 . The compound of claim 34 , wherein A 1 and A 2 together form ═NOH or ═NOCH 3 .
39 . The compound of claim 34 , wherein one Q is N.
40 . The compound of claim 34 , wherein each X is independently selected from the group consisting of H, F, Cl, Br, I, CH 3 , OH, NH 2 , (CH 3 ) 2 N, NHAc, CF 3 SO 3 , unsubstituted phenyl, phenyl substituted with a substituent selected from the group consisting of nitro and methoxy.
41 . The compound of claim 34 , wherein R is H, alkyl or benzyl.
42 . The method of claim 34 , wherein said alkyl group in the definition of R is represented by the formula —(CH 2 ), —Y, wherein Y is a halogen and n is an integer from 1 to 8.
43 . The compound of claim 34 , wherein the compound is represented by formula (Ia):
wherein
A 1 and A 2 are as defined in claim 34;
X 1 , X 2 , X 3 and X 4 are each, independently, H, halogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, —OH, —OR, —CH 2 —CO 2 R, —CO—R, —CO 2 R, —N(R) 2 , —NR—CO—R, —CO—N(R) 2 , —NRCO 2 R, —SO 3 CF 3 , —NO 2 , —N 3 , —CF 3 , —CH═CHY, or —CN;
Y is as defined in claim 34; and
R is as defined in claim 34 .
44 . The compound of claim 34 , wherein at least one X is aryl.
45 . The compound of claim 44 , wherein said aryl is unsubstituted phenyl or phenyl substituted with one or more substituents selected from the group consisting of halogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, —OH, —OR, —CH 2 —CO 2 R, —CO—R, —CO 2 R, —N(R) 2 , —NR—CO—R, —CO—N(R) 2 , —NRCO 2 R, —SO 3 CF 3 , —NO 2 , —N 3 , —CF 3 , —CH═CHY and —CN.
46 . The compound of claim 34 , wherein the compound is represented by formula (Ib):
wherein
A 1 and A 2 are as defined in claim 34;
X 1 , X 3 and X 4 are each, independently, H, halogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, —OH, —OR, —CH 2 —CO 2 R, —CO—R, —CO 2 R, —N(R) 2 , —NR—CO—R, —CO—N(R) 2 , —NRCO 2 R, —SO 3 CF 3 , —NO 2 , —N 3 , —CF 3 , —CH═CHY, or —CN; and
R is as defined in claim 34;
Y is as defined in claim 34;
each S is, independently, halogen, alkyl, alkenyl, alkynyl, phenyl, aralkyl, —OH, —OR, —CH 2 —CO 2 R, —CO—R, —CO 2 R, —N(R) 2 , —NR—CO—R, —CO—N(R) 2 , —NRCO 2 R, —SO 3 CF 3 , —NO 2 , —N 3 , —CF 3 , —CH═CHY, or —CN, or
two S, taken together with the phenyl group to which they are bonded, form a 2-naphthyl group; and
c is O, 1, 2, 3, 4 or 5
47 . A compound represented by formula (II):
wherein
A 3 is —R, —N(R) 2 , —C(═NR)N(R) 2 , or —OR;
each Q is, independently, C—X or N, with the proviso that at least one Q is N and at least one Q is C—X;
each X is, independently, H, halogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, —OH, —OR, —CH 2 —CO 2 R, —CO—R, —CO 2 R, —N(R) 2 , —NR—CO—R, —CO—N(R) 2 , —NRCO 2 R, —SO 3 CF 3 , —NO 2 , —N 3 , —CF 3 , —CH═CHY, or —CN, with the proviso that at least one X is aryl;
Y is a halogen; and
each R is, independently, H, alkyl, alkenyl, alkynyl, aryl, or aralkyl;
or a pharmaceutically acceptable salt thereof.
48 . The compound of claim 47 , wherein A 3 is H or alkyl.
49 . The compound of claim 47 , wherein A 3 is H.
50 . The compound of claim 47 , wherein one Q is N.
51 . The compound of claim 47 , wherein each X is independently selected from the group consisting of H, F, Cl, Br, I, CH 3 , OH, NH 2 , (CH 3 ) 2 N, NHAc, CF 3 SO 3 , unsubstituted phenyl, phenyl substituted with a substituent selected from the group consisting of nitro and methoxy.
52 . The compound of claim 47 , wherein R is H, alkyl or benzyl.
53 . The compound of claim 47 , wherein said aryl is unsubstituted phenyl or phenyl substituted with one or more substituents selected from the group consisting of halogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, —OH, —OR, —CH 2 —CO 2 R, —CO—R, —CO 2 R, —N(R) 2 , —NR—CO—R, —CO—N(R) 2 , —NRCO 2 R, —SO 3 CF 3 , —NO 2 , —N 3 , —CF 3 , —CH═CHY and —CN.
54 . The method of claim 47 , wherein said alkyl group in the definition of R is represented by the formula —(CH 2 ) n —Y, wherein Y is a halogen and n is an integer from 1 to 8.
55 . The compound of claim 47 , wherein the compound is represented by formula (IIa):
wherein
A 3 is as defined in claim 47;
X 1 , X 2 , X 3 and X 4 are X 1 , X 2 , X 3 and X 4 are each, independently, H, halogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, —OH, —OR, —CH 2 —CO 2 R, —CO—R, —CO 2 R, —N(R) 2 , —NR—CO—R, —CO—N(R) 2 , —NRCO 2 R, —SO 3 CF 3 , —NO 2 , —N 3 , —CF 3 , —CH═CHY, or —CN;
Y is as defined in claim 47; and
R is as defined in claim 47 .
56 . The compound of claim 47 , wherein the compound is represented by formula (IIb):
wherein
A 3 is as defined in claim 47;
X 1 , X 2 , X 3 and X 4 are each, independently, H, halogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, —OH, —OR, —CH 2 —CO 2 R, —CO—R, —CO 2 R, —N(R) 2 , —NR—CO—R, —CO—N(R) 2 , —NRCO 2 R, —SO 3 CF 3 , —NO 2 , —N 3 , —CF 3 , —CH═CHY, or —CN;
R is as defined in claim 47;
Y is as defined in claim 47;
each S is, independently, halogen, alkyl, alkenyl, alkynyl, phenyl, aralkyl, —OH, —OR, —CH 2 —CO 2 R, —CO—R, —CO 2 R, —N(R) 2 , —NR—CO—R, —CO—N(R) 2 , —NRCO 2 R, —SO 3 CF 3 , —NO 2 , —N 3 , —CF 3 , —CH═CHY, or —CN, or
two S, taken together with the phenyl group to which they are bonded, form a 2-naphthyl group; and
c is 0, 1, 2, 3, 4 or 5.
57 . A compound represented by formula (III):
wherein
Z is —(CH 2 ) m —, —O—, —NR—, —(CH 2 ) m —O—, —O—(CH 2 ) m —, —(CH 2 ) m N(R)—, —N(R)(CH 2 ) m —, —C(═NR)—, —(CH 2 ) m S—, —(CH 2 ) m CH═CH—, or —(CH 2 ) m C≡C—;
m is 1, 2, 3 or 4;
each Q is, independently, C—X or N, with the proviso that at least one Q is N and at least one Q is C—X;
each X is, independently, H, halogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, —OH, —OR, —CH 2 —CO 2 R, —CO—R, —CO 2 R, —N(R) 2 , —NR—CO—R, —CO—N(R) 2 , —NRCO 2 R, —SO 3 CF 3 , —NO 2 , —N 3 , —CF 3 , —CH═CHY, or —CN;
Y is a halogen; and
each R is, independently, H, alkyl, alkenyl, alkynyl, aryl, or aralkyl;
or a pharmaceutically acceptable salt thereof.
58 . The compound of claim 57 , wherein Z is —CH 2 —.
59 . The compound of claim 57 , wherein one Q is N.
60 . The compound of claim 57 , wherein each X is independently selected from the group consisting of H, F, Cl, Br, I, CH 3 , OH, NH 2 , (CH 3 ) 2 N, NHAc, CF 3 SO 3 , unsubstituted phenyl, phenyl substituted with a substituent selected from the group consisting of nitro and methoxy.
61 . The compound of claim 57 , wherein at least one X is aryl.
62 . The compound of claim 61 , wherein said aryl is unsubstituted phenyl or phenyl substituted with one or more substituents selected from the group consisting of halogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, —OH, —OR, —CH 2 —CO 2 R, —CO—R, —CO 2 R, —N(R) 2 , —NR—CO—R, —CO—N(R) 2 , —NRCO 2 R, —SO 3 CF 3 , —NO 2 , —N 3 , —CF 3 , —CH═CHY and —CN.
63 . The method of claim 57 , wherein said alkyl group in the definition of R is represented by the formula —(CH 2 ).—Y, wherein Y is a halogen and n is an integer from 1 to 8.
64 . The compound of claim 57 , wherein the compound is represented by (IIa):
wherein
Z is as defined in claim 57; and
X 1 , X 2 and X 3 are each, independently, H, halogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, —OH, —OR, —CH 2 —CO 2 R, —CO—R, —CO 2 R, —N(R) 2 , —NR—CO—R, —CO—N(R) 2 , —NRCO 2 R, —SO 3 CF 3 , —NO 2 , —N 3 , —CF 3 , —CH═CHY, or —CN;
Y is as defined in claim 57; and
R is as defined claim 57 .
65 . The compound of claim 57 , wherein the compound is represented by formula (IIIb):
wherein
Z is as defined in claim 57;
X 1 , X 2 and X 3 are each, independently, H, halogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, —OH, —OR, —CH 2 —CO 2 R, —CO—R, —CO 2 R, —N(R) 2 , —NR—CO—R, —CO—N(R) 2 , —NRCO 2 R, —SO 3 CF 3 , —NO 2 , —N 3 , —CF 3 , —CH═CHY, or —CN;
Y is as defined in claim 57; and
R is as defined in claim 57 .
66 . The compound of claim 34 , which is labeled with at least one labeling atom.
67 . The compound of claim 47 , which is labeled with at least one labeling atom.
68 . The compound of claim 57 , which is labeled with at least one labeling atom.
69 . A method of treating a condition selected from the group consisting of Alzheimer's disease, Parkinson's disease, pain, depression, Tourette's syndrome, inflammatory bowel syndrome, schizophrenia, anxiety, epilepsy, attention-deficit hyperactivity disorder, ulcerative colitis and obesity, comprising administering an effective amount of the compound of claim 34 to a patient in need thereof.
70 . A method of treating a condition selected from the group consisting of Alzheimer's disease, Parkinson's disease, pain, depression, Tourette's syndrome, inflammatory bowel syndrome, schizophrenia, anxiety, epilepsy, attention-deficit hyperactivity disorder, ulcerative colitis and obesity, comprising administering an effective amount of the compound of claim 47 to a patient in need thereof.
71 . A method of treating a condition selected from the group consisting of Alzheimer's disease, Parkinson's disease, pain, depression, Tourette's syndrome, inflammatory bowel syndrome, schizophrenia, anxiety, epilepsy, attention-deficit hyperactivity disorder, ulcerative colitis and obesity, comprising administering an effective amount of the compound of claim 57 to a patient in need thereof.Join the waitlist — get patent alerts
Track US2003176434A1 — get alerts on status changes and closely related new filings.
We store only your email — no account needed. See our privacy policy.