Chemokine

Abstract

The present invention relates to the discovery of novel genes and proteins, which function in pathways involved in brain pathogenesis. In particular, the novel genes and proteins relate to inflammatory tissue responses caused by brain injuries such trauma, ischemia or autoimmune-inflammation or other diseases or processes related to neuroinflammation. The compounds disclosed in the present invention are useful as therapeutics, diagnostics and in screening assays.

What is claimed is:  
     
         1 . At least one isolated nucleic acid molecule selected from: 
 (a) a nucleic acid molecule comprising of a sequence selected from SEQ ID NO:1 or a complement thereof,    (b) a nucleic acid molecule encoding a polypeptide comprising a sequence comprising of sequence SEQ ID No:2 or SEQ ID NO:3.    
     
     
         2 . A vector, comprising the nucleic acid molecule of  claim 1 .  
     
     
         3 . An expression vector, comprising the nucleic acid molecule of  claim 1  operably linked to a transcriptional regulatory sequence.  
     
     
         4 . A host cell transfected with the expression vector of  claim 3 .  
     
     
         5 . A method of obtaining an isolated polypeptide encoded by a nucleic acid molecule selected from: 
 (a) a nucleic acid molecule consisting of a sequence SEQ ID NO:1; and    (b) a nucleic acid molecule encoding a polypeptide comprising a sequence comprising sequence SEQ ID No:2 or SEQ ID NO:3.    
     
     
         6 . A nucleic acid molecule having a sequence comprising the sequence of nucleotides 53 to 340 of SEQ ID NO:1.  
     
     
         7 . The nucleic acid molecule of  claim 6  having the sequence SEQ ID NO:1.  
     
     
         8 . An expression vector, comprising the nucleic acid molecule of  claim 6  operably linked to a transcriptional regulatory sequence.  
     
     
         9 . A host cell transfected with the expression vector of  claim 8.