Transgenic non-human mammals carrying human pituitary tumor transforming gene (PTTG) sequences

Abstract

Disclosed is a transgenic non-human mammal, which carries in its cells an exogenously supplied human pituitary tumor transforming gene (PTTG) polynucleotide sequence.

We claim:  
     
         1 . A transgenic non-human mammal, wherein the non-human mammal carries in its cells at least one exogenous nucleic acid comprising a polynucleotide having a nucleotide sequence consisting of: 
 (A) contiguous nucleotide positions 95-700 of SEQ ID NO:3;    (B) a degenerate sequence of (A); or    (C) a sequence complementary to (A) or (B).    
     
     
         2 . The transgenic non-human mammal of  claim 1 , wherein the polynucleotide encodes a PTTG protein having an amino acid sequence of SEQ ID NO:4.  
     
     
         3 . The transgenic non-human mammal of  claim 1 , wherein the non-human mammal is a mouse.  
     
     
         4 . The transgenic non-human mammal of  claim 1 , wherein the polynucleotide is operatively linked to a promoter.  
     
     
         5 . The transgenic non-human mammal of  claim 4 , wherein the promoter is an inducible promoter and/or a tissue specific promoter.  
     
     
         6 . The transgenic non-human mammal of  claim 4 , wherein the polynucleotide is operatively linked to the promoter, such that transcription of the polynucleotide results in an antisense mRNA complementary to contiguous nucleotide positions 95-700 of SEQ ID NO:3.  
     
     
         7 . The transgenic non-human mammal of  claim 4 , wherein the polynucleotide further comprises a mutation, such that transcription and translation result in inactive human PTTG protein being produced.