Galenical formulations

Abstract

A pharmaceutical composition containing macrolide, e.g. a rapamycin compound in an emulsion preconcentrate or microemulsion preconcentrate for oral administration. The carrier medium for the rapamycin compound includes a hydrophilic phase, a lipophilic phase and a surfactant. The composition is stable and provides high absorption efficiency.

1 . A pharmaceutical composition comprising a macrolide and a carrier medium comprising a hydrophilic phase, a lipophilic phase and a surfactant.  
     
     
         2 . A composition according to  claim 1  in the form of an emulsion or a microemulsion preconcentrate.  
     
     
         3 . A composition according to  claim 1  or  claim 2  in which the lipophilic phase comprises 10 to 85% by weight of the carrier medium.  
     
     
         4 . A composition according to any one of  claims 1  to  3  in which the surfactant comprises 5 to 80% by weight of the carrier medium.  
     
     
         5 . A composition according to any one of  claims 1  to  4  in which the hydrophilic phase comprises 10 to 50% by weight of the carrier medium.  
     
     
         6 . A composition according to any one of  claims 1  to  5  in which the compound of the rapamycin class is present in an amount of 2 to 15% by weight of the composition.  
     
     
         7 . A composition according to any one of  claims 1  to  6  in which the macrolide is a compound of the rapamycin class.  
     
     
         8 . A composition according to any one of  claims 1  to  6  in which the macrolide is a FK 506 compound.  
     
     
         9 . An microemulsion preconcentrate carrier medium for an orally administrable active agent other than a cyclosporin which comprises 
 i) a reaction product of a castor oil and ethylene oxide,    ii) a transesterification product of a vegetable oil and glycerol comprising predominantly linoleic acid or oleic acid, mono-, di- and triglycerides or a polyoxyalkylated vegetable oil,    iii) 1,2 propylene glycol and    iv) ethanol.