Acylsulfonamide derivative

Abstract

This invention provides a novel acylsulfonamide derivative which can be used as an ACC activity inhibitor effective for the treatment of visceral fat syndrome that becomes the risk-factor of diseases of adult people such as myocardial infarction, cerebral infarction and diabetes. Particularly, it relates to an acylsulfonamide derivative represented by a general formula 1 wherein R 1 is substituted/unsubstituted C 1 -C 12 alkyl or alkoxy group or substituted/unsubstituted C 2 -C 12 alkenyl or alkynyl group, R 2 is hydrogen atom, hydroxyl group, mercapto group, substituted/unsubstituted C 1 -C 6 alkoxy or alkylthio group, nitro group, halogen atom, trichloromethyl group, trifluoromethyl group or cyano group, R 3 is substituted/unsubstituted C 1 -C 20 alkyl or alkoxy group, substituted/unsubstituted C 2 -C 20 alkenyl or alkynyl group, substituted/unsubstituted aromatic hydrocarbon or aromatic heterocyclic group, substituted amino group, substituted/unsubstituted C 2 -C 20 alkenyloxy or alkynyloxy group or R 4 O— (wherein R 4 is substituted/unsubstituted aromatic hydrocarbon or aromatic heterocyclic group), Y is —CH═CH—, —N═CH—, —CH═N—, sulfur or oxygen, and ring A is aromatic hydrocarbon, aromatic heterocyclic ring or cyclic alkyl group.

What is claimed is:  
     
         1 . An acylsulfonamide derivative represented by a general formula 1  
       
         
           
           
               
               
           
         
       
       wherein 
 R 1  represents a substituted or unsubstituted C 1 -C 12  alkyl group, a substituted or unsubstituted C 2 -C 12  alkenyl group, a substituted or unsubstituted C 2 -C 12  alkynyl group or a substituted or unsubstituted C 1 -C 12  alkoxy group,  
 R 2  represents a hydrogen atom, a hydroxyl group, a mercapto group, a substituted or unsubstituted C 1 -C 6  alkoxy group, a substituted or unsubstituted C 1 -C 6  alkylthio group, a nitro group, a halogen atom, a trichloromethyl group, a trifluoromethyl group or a cyano group,  
 R 3  represents a substituted or unsubstituted C 1 -C 20  alkyl group, a substituted or unsubstituted C 2 -C 20  alkenyl group, a substituted or unsubstituted C 2 -C 20  alkynyl group, a substituted or unsubstituted aromatic hydrocarbon group, a substituted or unsubstituted aromatic heterocyclic group, a substituted amino group, a substituted or unsubstituted C 1 -C 20  alkoxy group, a substituted or unsubstituted C 2 -C 20  alkenyloxy group, a substituted or unsubstituted C 2 -C 20  alkynyloxy group or a group represented by R 4 O— (wherein R 4  represents a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted aromatic heterocyclic group),  
 Y is a group represented by CH═CH—, —N═CH— or —CH═N—, sulfur atom or oxygen atom, and  
 ring A represents a substituted or unsubstituted aromatic hydrocarbon group, a substituted or unsubstituted aromatic heterocyclic group or a substituted or unsubstituted cyclic alkyl group.  
 
     
     
         2 . An acylsulfonamide derivative according to  claim 1 , wherein the ring A is an aromatic hydrocarbon group having a substitution position at the 1,2-position, an aromatic heterocyclic group having a substitution position at the 1,2-position or a cyclic alkyl group having a substitution position at the 1,1-position.  
     
     
         3 . An acylsulfonamide derivative according to  claim 2 , wherein R 1  is a C 1 -C 4  alkyl group having a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted aromatic heterocyclic group as a substituent, a C 2 -C 4  alkenyl group having a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted aromatic heterocyclic group as a substituent, a C 2 -C 4  alkynyl group having a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted aromatic heterocyclic group as a substituent or a C 1 -C 4  alkoxy group having a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted aromatic heterocyclic group as a substituent.  
     
     
         4 . An acylsulfonamide derivative according to  claim 2 , wherein R 1  is an unsubstituted C 5 -C 12  alkyl group, an unsubstituted C 5 -C 12  alkenyl group, an unsubstituted C 5 -C 12  alkynyl group or an unsubstituted C 5 -C 12  alkoxy group.  
     
     
         5 . A medicament which comprises any one of the acylsulfonamide derivatives of  claims 1  to  4 , or a pharmacologically acceptable salt thereof, as an active ingredient.