US2003159166A1PendingUtilityA1

H2-O modified transgenic animals

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Priority: Feb 17, 1998Filed: Feb 28, 2002Published: Aug 21, 2003
Est. expiryFeb 17, 2018(expired)· nominal 20-yr term from priority
Inventors:Lars KarlssonWai-Ping LeungPer A. PetersonChristopher Alfonso
A01K 2207/15A01K 67/0276A01K 2217/00C12N 15/8509A01K 2227/105C07K 14/4703A01K 2267/03A01K 2217/075
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Claims

Abstract

A transgenic animal with alterations in an H2-O gene is prepared by introduction of an altered H2-O gene into a host animal. The resulting transgenic animals produce a substantially greater frequency of high affinity antibodies compared to H2-O wild type animals. A method for the production of high affinity antibodies is disclosed.

Claims

exact text as granted — not AI-modified
What is claimed is:  
     
         1 . A method for the production of B-cells, comprising: 
 a) immunizing an H2-O−/− mouse with a sufficient amount of an antigen to produce an immune response; and    b) collecting B-cells from said immunized mouse.    
     
     
         2 . A method for the production of antibodies, comprising: 
 a) immunizing an H2-O−/− mouse with a sufficient amount of an antigen to cause antibody production; and    b) collecting antibodies from said immunized mouse.

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