Substituted (aminoiminomethyl or aminomethyl) benzoheteroaryl compounds

Abstract

This invention is directed to an (aminoiminomethyl or aminomethyl)benzoheteroaryl compound of formula I which is useful for inhibiting the activity of Factor Xa by combining said compound with a composition containing Factor Xa. The present invention is also directed to compositions containing compounds of the formula I, methods for their preparation, their use, such as in inhibiting the formation of thrombin or for treating a patient suffering from, or subject to, a disease state associated with a physiologically detrimental excess amount of thrombin.

What is claimed is:  
     
         1 . A compound of formula I:  
       
         
           
           
               
               
           
         
       
       wherein 
 X is O, S or NR 1 ;  
 R is hydrogen, cycloalkyl, cycloalkenyl, heterocyclyl, heterocyclenyl, fused arylcycloalkyl, fused heteroarylcycloalkyl, fused arylcycloalkenyl, fused heteroarylcycloalkenyl, fused arylheterocyclyl, fused heteroarylheterocyclyl, fused arylheterocyclenyl, fused heteroarylheterocyclenyl, aryl, fused cycloalkenylaryl, fused cycloalkylaryl, fused heterocyclylaryl, fused heterocyclenylaryl, heteroaryl, fused cycloalkylheteroaryl, fused cycloalkenylheteroaryl, fused heterocyclenylheteroaryl or fused heterocyclylheteroaryl, provided that where L 2  is a chemical bond then Q is attached to R through a carbon atom thereof or where R is hydrogen then L 2  is not a chemical bond;  
 R 1  is hydrogen, alkyl, aralkyl, heteroaralkyl, acyl, aroyl, heteroaroyl, alkoxycarbonyl, aryloxycarbonyl or heteroaryloxycarbonyl;  
 R 2  and R 3  are hydrogen, or taken together are ═NR 4 ;  
 R 4  is hydrogen, R 5 O 2 C—, R 5 O—, HO—, cyano, R 5 CO—, HCO—, lower alkyl, nitro, or R 6 R 7 N—;  
 R 5  is alkyl, aryl, heteroaryl, aralkyl, or heteroaralkyl;  
 R 6  and R 7  are independently hydrogen or alkyl;  
 L 1  is alkylene, alkenylene or alkynylene;  
 L 2  is a chemical bond, alkylene, alkenylene or alkynylene;  
 Q is —NR 8′ , —O—, —C(O)—, —C(O)—O—, —O—C(O)—, —NR 8′ C(X 1 )—, —C(X 1 )NR 8′ —, —NR 8 C(X 1 )O—, —OC(X 1 )NR 8 —, —NR 8 C(X 1 )NR 8 —, —NR 8 C(X 1 )NR 8 —, —S(O) n —, —NR 8 SO 2 — or —SO 2 NR 8 —, provided that a nitrogen atom or oxygen atom of Q is not directly bonded to a carbon atom of L 1  or L 2  having a double bond or triple bond, or Q-L 2 -R is cycloalkyl, cycloalkenyl, heterocyclyl, heterocyclenyl, fused arylcycloalkyl, fused heteroarylcycloalkyl, fused arylcycloalkenyl, fused heteroarylcycloalkenyl, fused arylheterocyclyl, fused heteroarylheterocyclyl, fused arylheterocyclenyl, fused heteroarylheterocyclenyl, aryl, fused cycloalkenylaryl, fused cycloalkylaryl, fused heterocyclylaryl, fused heterocyclenylaryl, heteroaryl, fused cycloalkylheteroaryl, fused cycloalkenylheteroaryl, fused heterocyclenylheteroaryl or fused heterocyclylheteroaryl, provided that a nitrogen atom or oxygen atom of Q is not directly bonded to a carbon atom of L 1  having a double bond or triple bond;  
 X 1  is O or S;  
 R 8′  is hydrogen, alkyl, aralkyl, heteroaralkyl, acyl, aroyl, heteroaroyl or alkoxycarbonyl;  
 R 8  is hydrogen, alkyl, aralkyl, heteroaralkyl, acyl, aroyl or heteroaroyl; and  
 n is 0, 1 or 2, or  
 an oxide thereof, a pharmaceutically acceptable salt thereof, a solvate thereof, or prodrug thereof.  
 
     
     
         2 . The compound of  claim 1  wherein R is aryl, heteroaryl or heterocyclyl.  
     
     
         3 . The compound of  claim 1  wherein R is substituted phenyl.  
     
     
         4 . The compound of  claim 1  wherein R is optionally substituted (phenyl substituted phenyl), optionally substituted (heteroaryl substituted phenyl), optionally substituted (phenyl substituted heteroaryl), optionally substituted (heteroaryl substituted heteroaryl), optionally substituted (phenyl substituted cyclyoalkyl), optionally substituted (heteroaryl substituted cyclyoalkyl), optionally substituted (cyclyoalkyl substituted heteroaryl), optionally substituted (cyclyoalkyl substituted phenyl), optionally substituted (cyclyoalkyl substituted cyclyoalkyl), optionally substituted (phenyl substituted cyclyoalkenyl), optionally substituted (heteroaryl substituted cyclyoalkenyl), optionally substituted (cyclyoalkenyl substituted heteroaryl), optionally substituted (cyclyoalkenyl substituted phenyl), optionally substituted (cyclyoalkenyl substituted cyclyoalkenyl), optionally substituted (phenyl substituted heterocyclyl), optionally substituted (heteroaryl substituted heterocyclyl), optionally substituted (cyclyoalkyl substituted heterocyclyl), optionally substituted (heterocyclyl substituted phenyl), optionally substituted (heterocyclyl substituted heterocyclyl), optionally substituted (phenyl substituted heterocyclenyl), optionally substituted (heteroaryl substituted heterocyclenyl), optionally substituted (cyclyoalkenyl substituted heterocyclenyl), optionally substituted (heterocyclenyl substituted phenyl), or optionally substituted (heterocyclenyl substituted heterocyclenyl).  
     
     
         5 . The compound of  claim 1  wherein R is optionally substituted (phenyl substituted phenyl), optionally substituted (heteroaryl substituted phenyl), optionally substituted (phenyl substituted heteroaryl), optionally substituted (heteroaryl substituted heteroaryl), optionally substituted (phenyl substituted heterocyclyl), optionally substituted (heteroaryl substituted heterocyclyl), optionally substituted (cyclyoalkyl substituted heterocyclyl), optionally substituted (heterocyclyl substituted phenyl), optionally substituted (heterocyclyl substituted heterocyclyl), optionally substituted (phenyl substituted heterocyclenyl), optionally substituted (heteroaryl substituted heterocyclenyl), optionally substituted (cyclyoalkenyl substituted heterocyclenyl), optionally substituted (heterocyclenyl substituted phenyl), or optionally substituted (heterocyclenyl substituted heterocyclenyl).  
     
     
         6 . The compound of  claim 1  wherein R is optionally substituted (phenyl substituted heteroaryl), optionally substituted (phenyl substituted heterocyclyl), or optionally substituted (phenyl substituted heterocyclenyl).  
     
     
         7 . The compound of  claim 1  wherein R is optionally substituted (phenyl substituted heteroaryl), optionally substituted (phenyl substituted heterocyclyl), or optionally substituted (phenyl substituted heterocyclenyl); L 2  is bonded to said phenyl in the 1-position of the phenyl moiety and said heterocyclyl, heterocyclenyl, or heteroaryl, is bonded to said phenyl in the 4-position of the phenyl moiety.  
     
     
         8 . The compound of  claim 1  wherein X is NR 1 .  
     
     
         9 . The compound of  claim 1  wherein R 1  is hydrogen.  
     
     
         10 . The compound of  claim 1  wherein R 8  is hydrogen.  
     
     
         11 . The compound of  claim 1  wherein R 1  and R 3  taken together are ═NR 4 .  
     
     
         12 . The compound of  claim 1  wherein R 4  is hydrogen.  
     
     
         13 . The compound of  claim 1  wherein R 5  is alkyl.  
     
     
         14 . The compound of  claim 9  wherein R 5  is methyl.  
     
     
         15 . The compound of  claim 1  wherein R 6  and R 7  are hydrogen.  
     
     
         16 . The compound of  claim 1  wherein L 1  is alkylene.  
     
     
         17 . The compound of  claim 1  wherein L 1  is ethylene.  
     
     
         18 . The compound of  claim 1  wherein L 1  is bonded to the 5-position of the  
       
         
           
           
               
               
           
         
       
       moiety.  
     
     
         19 . The compound of  claim 1  wherein L 2  is a chemical bond or alkylene.  
     
     
         20 . The compound of  claim 14  wherein L 2  is a chemical bond.  
     
     
         21 . The compound of  claim 1  wherein X 1  is O.  
     
     
         22 . The compound of  claim 1  wherein Q is —NR 8 CO, —CONR 8 —, —NR 8 SO 2 — or —SO 2 NR 8 —.  
     
     
         23 . The compound of  claim 1  wherein Q is —NR 8 CO—.  
     
     
         24 . The compound of  claim 1  wherein R 8  and R 8′  are hydrogen.  
     
     
         25 . The compound of  claim 1  wherein n is 2.  
     
     
         26 . The compound of  claim 1  wherein L 1  is bonded to the 5-position of the  
       
         
           
           
               
               
           
         
       
       moiety; and 
 R is optionally substituted (phenyl substituted pyridinonyl), optionally substituted (phenyl substituted pyrrolopyrimidinyl), optionally substituted (phenyl substituted pyridazinyl), optionally substituted (phenyl substituted pyridazinonyl), optionally substituted (phenyl substituted pyridyl), or optionally substituted (phenyl substituted pyrimidinyl).  
 
     
     
         27 . The compound of  claim 1  wherein R is substituted (phenyl substituted pyrimidinyl), said pyrimidinyl is substituted with at least one ring system substituent selected from the group consisting of alkoxy, Y 1 Y 2 N-alkyl-, Y 1 Y 2 N—, azaheterocyclyl, Y 1 Y 2 NCO-alkylene-O—, azaheterocyclyl-alkylene-O—, and Y 1 Y 2 N-alkylene-O—; wherein 
 Y 1  and Y 2  are independently hydrogen, alkyl, alkoxyalkyl, hydroxyalkyl, cycloalkyl, cycloalkyl-alkyl, Y 1 Y 2 N-alkyl, aryl, aralkyl, heteroaralkyl, heterocyclylalkyl, heterocyclenylalkyl, or sulfo-alkyl-; or when  
 Y 1  is H—CO—, alkyl-CO—, aryl-CO—, or heterocyclyl-CO—, then Y 2  is hydrogen, alkyl, aryl, or aralkyl.  
 
     
     
         28 . A compound according to  claim 1  which is selected from the group consisting of 
 N-(2-[3-Carbamimidoyl-5-indolyl]ethyl)-4-pyrid-3-ylbenzamide;  
 N-(2-[3-Carbamimidoyl-5-indolyl]ethyl)-4-(pyrimidin-5-yl)-benzamide);  
 5-(Pyrid-2-yl)-thiophene-2-carboxylic acid 2-(3-Carbamimidoyl-5-indolyl)ethyl amide;  
 N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-6-morpholin-4-ylnicotinamide-4-(5-2[-{3-Carbamimidoylindol-5-yl}ethylcarbamoyl]pyridin-2-yl)piperazine-1-carboxylic acid ethyl ester;  
 N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-6-imidazol-1-ylnicotinamide;  
 N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-4-imidazol-1-ylbenzamide;  
 N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-4-(3H-imidazol-4-yl)benzamide;  
 N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-4-(1,2,4)thiadiazol-5-ylbenzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(1-carbamoyl-1-methyl-ethyl-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(1-[N-(2-methoxyethyl)]-carbamoyl-1-methyl-ethyl-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(t-butyl)-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(pyridazin-4-yl)-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-2-methyl-4-(6-oxo-1,6-dihydro-pyridin-3-yl)-benzamide  
 3′,4′-Dimethoxybiphenyl-4-carboxylic acid (2-[3-Carbamimidoylindol-5-yl]ethyl)amide;  
 N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-4-(6-methoxypyrid-3-yl)benzamide;  
 N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-4-(1-oxy-pyrid-4-yl)benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(7H-pyrrolo[2,3-d]pyrimidin-6-yl)-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(1H-pyrrolo[3,2-c]pyridin-2-yl)-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-furo[3,2-c]pyridin-2-yl-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-3-chloro-4-(6-oxo-1,6-dihydro-pyridin-3-yl)-benzamide;  
 N-(2-[3-Carbamimidoyl-1H-indol-5-yl]ethyl)-4-(6-oxo-1,6-dihydro-pyrid-3-yl)benzamide;  
 4-(3-Amino-1,1-dimethyl-propyl)-N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-etlyl]-2-(4-chloro-phenyl)-acetamide;  
 5-chloro-thiophene-2-carboxylic acid [2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-amide;  
 N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-6-(2-hydroxyethylamino)nicotinamide;  
 N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-6-(1,2,4)-triazol-1-ylnicotinamide;  
 N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-6-pyrrol-1-ylnicotinamide;  
 N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-6-pyrazol-1-ylnicotinamide;  
 N-(2-[3-Carbamimidoyl-1-methylindol-5-yl]ethyl)-4-(6-methoxypyrid-3-yl)benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-3-chloro-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-2-(3-chloro-phenyl)-acetamide;  
 4-(2-Aminomethyl-pyridin-4-yl)-N-[2-(3-Carbamimidoyl]-1H-indol-5-yl)-ethyl]-benzamide;  
 4-{4-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethylcarbamoyl]-phenyl-pyridine-2-carboxylic acid amide;  
 N-[2-(3-Carbamimidoy-1H-indol-5-yl)-ethyl]-4-(2-(N,N-dimethylaminomethyl)-pyridin-4-yl)benzamide);  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(6-oxo-1,6-dihydro-pyridazin-3-yl)-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(6-methoxy-pyridazin-3-yl)-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[1-(2-dimethylamino-ethyl)-6-oxo-1,6-dihydro-pyridazin-3-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[1-(3-dimethylamino-propyl)-6-oxo-1,6-dihydro-pyridazin-3-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(2-dimethylamino-ethylamino)-pyrimidin-4-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-methoxy-pyrimidin-4-yl]-benzamide;  
 N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-4-(1-[2-dimethylaminoethyl]-6-oxo-1,6-dihydropyridin-3-yl)benzamide;  
 N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-4-(1-carbamoylmethyl-6-oxo-1,6-dihydropyridin-3-yl)benzamide;  
 4-(3-Amino-[1,2,4]triazin-6-yl)-N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-benzamide;  
 4-(3-Amino-[1,2,4]triazin-5-yl)-N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(3-oxo-2,3-dihydro-[1,2,4]triazin-6-yl)-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5yl)ethyl]-4-(5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-benzamide  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl-4-(6-oxo-piperidin-3-yl)-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(morpholin-4yl-ethylamino)-pyrimidin-4-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(3-dimethylamino-propylamino)-pyrimidin-4-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-([2-dimethylamino-ethyl]-methyl-amino)-pyrimidin-4-yl]-benzamide;  
 2-[(4-{4-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethylcarbamoyl]-phenyl}-pyrimidin-2-yl)-methyl-amino]-ethanesulfonic acid;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-{2-[methyl-(2(S),3(R),4(R),5(R),6-pentahydroxy-hexyl)-amino]-pyrimidin-4-yl}-benzamide  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-{2-[methyl-(2(S),3(R),4(S),5(R),6-pentahydroxy-hexyl)-amino]-pyrimidin-4-yl}-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(2-hydroxy-1-hydroxymethyl-ethylamino)-pyrimidin-4-yl]-benzamide;  
 2-[(4-{4-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethylcarbamoyl]-phenyl}-pyrimidin-2-yl)-methyl-amino]-ethanesulfonic acid;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(3-imidazol-1-yl-propylamino)-pyrimidin-4-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-{2-[(2-diethylamino-ethyl)-methyl-amino]-pyrimidin-4-yl}-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(2-diisopropylamino-ethylamino)-pyrimidin-4-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(2-dibutylamino-ethylamino)-pyrimidin-4-yl]-benzamide  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(3-morpholin-4-yl-propylamino)-pyrimidin-4-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(3-diethylamino-propylamino)-pyrimidin-4-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(3-piperidin-1-yl-propylamino)-pyrimidin-4-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(2-{[2-(ethyl-methyl-amino)-ethyl]-methyl-amino}-pyrimidin-4-yl)-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(5-dimethylamino-pentylamino)-pyrimidin-4-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(5-morpholin-4-yl-pentylamino)-pyrimidin-4-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(5-piperidin-1-yl-pentylamino)-pyrimidin-4-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(5-pyrrolidin-1-yl-pentylamino)-pyrimidin-4-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(2-oxo-hexahydro-pyrimidin-5-yl)-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(1,3-dimethyl-2-oxo-hexahydro-pyrimidin-5-yl)-benzamide;  
 Biphenyl-3,4′-dicarboxylic acid 4′-{[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-amide} 3-[(2-methoxy-ethyl)-amide];  
 3′-(Morpholine-4-carbonyl)-biphenyl-4-carboxylic acid [2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-amide;  
 Biphenyl-3,4′-dicarboxylic acid 4′-{[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-amide} 3-[(2-morpholin-4-yl-ethyl)-amide];  
 Biphenyl-2,4′-dicarboxylic acid 4′-{[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-amide} 2-[(3-diethylamino-propyl)-amide];  
 Biphenyl-2,4′-dicarboxylic acid 4′-{[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-amide} 2-[(3-morpholin-4-yl-propyl)-amide];  
 Biphenyl-2,4′-dicarboxylic acid 4′-{[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-amide} 2-[(3-piperidin-1-yl-propyl)-amide];  
 Biphenyl-2,4′-dicarboxylic acid 4′-{[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-amide} 2-[(4-dimethylamino-butyl)-amide];  
 Biphenyl-2,4′-dicarboxylic acid 4′-{[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-amide} 2-[(2,3-dihydroxy-propyl)-methyl-amide];  
 Biphenyl-2,4′-dicarboxylic acid 4′-{[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-amide} 2-[(2,3-dihydroxy-propyl)-amide];  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(4-methylpiperazin-1-yl)pyrimidin-4-yl]benzamide;  
 4-[(4-{4-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethylcarbamoyl]phenyl}pyrimidin-2-yl)methylamino]butyric acid;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(2,2,2-trifluoroethoxy)pyrimidin-4-yl]benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(2-pyrrolidin-1-ylpyrimidin-4-yl)benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(2-hydroxymethylpyrrolidin-1-yl)-pyrimidin-4-yl]benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(carbamoylmethyl-N-methylamino)-pyrimidin-4-yl]benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(6-pyrrolidin-1-yl-hexylamino)pyrimidin-4-yl]benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(6-piperidin-1-ylhexylamino)pyrimidin-4-yl]benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(4-piperidin-1-ylbutylamino)pyrimidin-4-yl]benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(4-diethylaminobutylamino)pyrimidin-4-yl]benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)efhyl]-4-[2-(6-morpholin-4-ylhexylamino)pyrimidin-4-yl]benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(6-dimethylaminohexylamino)pyrimidin-4-yl]benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(4-dimethylaminobutylamino)pyrimidin-4-yl]benzamide;  
 4-[2-(Bicyclo[2;2;1]hept-2-ylamino)pyrimidin-4-yl]-N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]benzamide;  
 1-(4-{4-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethylcarbamoyl]phenyl}pyrimidin-2-yl)pyrrolidine-2-carboxylic acid amide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-{2-[(2-hydroxy-ethyl)-N-metflylaimno]pyrimidin-4-yl}benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(2-morpholin-4-yl-pyrimidin-4-yl)-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(cyclopropylmethyl-amino)-pyrimidin-4-yl]-benzamide;  
 N-[2-(Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-[(2-methoxy-ethyl)-methyl-amino]-pyridin-4-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(3-hydroxy-propylamino)-pyrimidin-4-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[(2-hydroxy-ethyl)-propyl-amino]-pyrimidin-4-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indole-5yl)-ethyl]-4-(2-piperidin-1-yl-pyrimidin-4-yl)-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(ethyl-methyl-amino)-pyridin-4-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(4-hydroxy-piperidin-1-yl)-pyrimidin-4-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(2,3-dihydroxy-propylamino)-pyrimidin-4-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-[(2,3-dihydroxy-propyl)-methyl-amino]-pyrimidin-4-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-((s)-2-methoxymethyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(2-piperazin-1-yl-pyrimidin-4-yl)-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-4-[2-[2-(2-oxo-imidazolidin-1-yl)-ethylamino]-pyrimidin-4-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(3-methoxy-propylamino)-pyrimidin-4-yl]-benzamide;  
 4-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(2-hydroxy-ethylamino)-pyrimidin-4-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(2-methoxyethoxy)-pyrimidin-4-yl]benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(1-carbamoylethoxy)pyrimidin-4-yl]benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(6-dimethylaminohexyloxy)pyrimidin-4-yl]benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(2-oxopiperidin-3-yloxy)pyrimidin-4-yl]benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(2-pyrrolidin-1-yl-ethoxy)pyrimidin-4-yl]benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(2-dimethylaminoethoxy)pyrimidin-4-yl]benzamide;  
 3′-(2-Dimethylaminoethoxy)biphenyl-4-carboxylic acid [2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]amide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-(1-oxypyridin-2-yl)benzamide;  
 2′-(2-Dimethylaminoethoxy)biphenyl-4-carboxylic acid [2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]amide;  
 2′-(3-Dimethylaminopropoxy)biphenyl-4-carboxylic acid [2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]amide;  
 3′-(3-Dimethylaminopropoxy)biphenyl-4-carboxylic acid [2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]amide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(1-oxo-pyridin-3-yl)-benzamide;  
 4-[2-(acetylamino-methyl)-pyridin-4-yl]-N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-benzamide;  
 Piperidine-4-carboxylic acid (4-[4-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethylcarbamoyl]-phenyl-]-pyridin-2-ylmethyl)-amide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[1-(3-dimethylaminopropyl)-6-oxo-1,6-dihydropyridin-3-yl]benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[6-(3-dimethylaminopropoxy)pyridin-3-yl]benzamide;  
 (5-{4-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethylcarbamoyl]phenyl}-2-oxo-2H-pyridin-1-yl)acetamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-{1-[(2-dimethylaminoethylcarbamoyl)methyl]-6-oxo-1,6-dihydropyridin-3-yl}benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(4-dimethylamino-piperidin-1-yl)-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[4-(2-dimethylamino-ethylamino)-piperidin-1-yl]benzamide;  
 4-(4-Amino-piperidin-1-yl)-N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(4-methoxy-piperidin-1-yl)-benzamide;  
 4-(4-Acetylamino-piperidin-1-yl)-N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-benzamide;  
 4-(1-Acetyl-piperidin-4-yl)-N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-benzamide;  
 4-{4-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethylcarbamoyl]-phenyl}-piperidine-1-carboxylic acid amide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(1-methyl-1-oxy-piperidin-4-yl)-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(1-methyl-piperidin-4-yl)-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(1-methanesulfonyl-piperidin-4-yl)-benzamide;  
 4-(2-Acetyl amino-1,1-dimethyl-ethyl)-N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(2-methanesulfonylamino-1,1-dimethyl-ethyl)-benzamide;  
 Piperidine-4-carboxylic acid (2-{4-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethylcarbamoyl]-phenyl}-2-methyl-propyl)-amide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(1,1-dimethyl-2-ureido-ethyl)-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(3-ethyl-ureido)-1,1-dimethyl-ethyl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(2-dimethylamino-3,4,5,6-tetrahydro-pyrimidin-4-yl)-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(1-oxy-pyridin-4-yloxy)-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(1-methyl-piperidin-4-yloxy)-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-(1,2,3,6-tetrahydropyridin-4-yl)-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-piperidin-4-yl-benzamide;  
 4-(2-Amino-1,1-dimethylethyl)-N-(2-[3-Carbamimidoylindol-5-yl]ethyl)benzamide;  
 N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-4-(6-[2-dimethylamnoethoxy]pyridin-3-yl)benzamide;  
 N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-4-pyrid-4-ylbenzamide;  
 N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-4-(4-carbamoyl-phenyl)-benzamide;  
 N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-4-(4-methoxy-phenyl)-benzamide;  
 N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-(5-methoxy-indol-2-yl)-carboxamide;  
 N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-(6-chloro-benzothiophen-2-yl)-carboxamide;  
 N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-4-(4-benzyloxy-phenyl)-benzamide;  
 N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-4-chloro-benzamide;  
 N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-4-(methylsulphonyl)-benzamide;  
 N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-4-(amino-sulphonyl)-benzamide;  
 4-(3-Aminoprop-1-ynyl)-N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-benzamide;  
 5-{4-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethylcarbamoyl]phenyl}-2-oxo-2H-pyridin-1-yl)acetic acid; and  
 3-Carbamimidoyl-5-{2-[4-(6-oxo-1,6-dihydro-pyridin-3-yl)-benzoylamino]-propyl}-indole.  
 
     
     
         29 . A compound according to  claim 28  which is selected from the group consisting of 
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(pyridazin-4-yl)-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-2-methyl-4-(6-oxo-1,6-dihydro-pyridin-3-yl)-benzamide;  
 N-(2-[3-Carbamimidoyl indol-5-yl]ethyl)-4-(6-methoxypyrid-3-yl)benzamide;  
 N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-4-(1-oxy-pyrid-4-yl)benzamide;  
 N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(7H-pyrrolo[2,3-d]pyrimidin-6-yl)-benzamide;  
 N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]—(1H-pyrrolo[3,2-c]pyridin-2-yl)-benzamide;  
 N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-3-chloro-4-(6-oxo-1,6-dihydro-pyridin-3-yl)-benzamide;  
 N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-4-(6-oxo-1,6-dihydropyrid-3-yl)benzamide;  
 4-(3-Amino-1,1-dimethyl-propyl)-N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-benzamide;  
 4-(2-Aminomethyl-pyridin-4-yl)-N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-benzamide;  
 4-{4-[2-(3-Carbamimidoy-1H-indol-5-yl)-ethylcarbamoyl]-phenyl-pyridine-2-carboylic acid amide;  
 N-[2-(3-Carbamimidoy-1H-indol-5-yl-ethyl]-4-(2-(N,N-dimethylaminomethyl)-pyridin-4-yl)benzamide);  
 N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(6-oxo-1,6-dihydro-pyridazin-3-yl)-benzamide;  
 N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(6-methoxy-pyridazin-3-yl)-benzamide;  
 N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[1-(2-dimethylamino-ethyl)-6-oxo-1,6-dihydro-pyridazin-3-yl]-benzamide;  
 N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[1-(3-dimethylamino-propyl)-6-oxo-1,6-dihydro-pyridazin-3-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(2-dimethylamino-ethylamino)-pyrimidin-4-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-methoxy-pyrimidin-4-yl]-benzamide;  
 N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-4-(1-[2-dimethylaminoethyl]-6-oxo-1,6-dihydropyridin-3-yl)benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl-4-(6-oxo-piperidin-3-yl)-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(morpholin-4yl-ethylamino)-pyridin-4-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(3-dimethylamino-propylamino)-pyrimidin-4-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl-ethyl]-4-[2-([2-dimethylamino-ethyl]-methyl-amino)-pyrimidin-4-yl]-benzamide;  
 2-[(4-{4-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethylcarbamoyl]-phenyl}-pyrimidin-2-yl)-methyl-amino]-ethanesulfonic acid;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-{2-[methyl-(2(S),3(R),4(R),5(R),6-pentahydroxy-hexyl)-amino]-pyrimidin-4-yl}-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-{2-[methyl-(2(S),3(R),4(S),5 (R),6-pentahydroxy-hexyl)-amino]-pyrimidin-4-yl}-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(2-hydroxy-1-hydroxymethyl-ethylamino)-pyrimidin-4-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(3-imidazol-1-yl-propylamino)-pyrimidin-4-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-{2-[(2-diethylamino-ethyl)-methyl-amino]-pyrimidin-4-yl}-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(2-diisopropylamino-ethylamino)-pyrimidin-4-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(2-dibutylamino-ethylamino)-pyrimidin-4-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(3-morpholin-4-yl-propylamino)-pyrimidin-4-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(3-diethylamino-propylamino)-pyrimidin-4-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(3-piperidin-1-yl-propylamino)-pyrimidin-4-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(2-{[2-(ethyl-methyl-amino)-ethyl]-methyl-amino}-pyrimidin-4-yl)-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(5-dimethylamino-pentylamino)-pyrimidin-4-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(5-morpholin-4-yl-pentylamino)-pyrimidin-4-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(5-piperidin-1-yl-pentylamino)-pyrimidin-4-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(5-pyrrolidin-1-yl-pentylamino)-pyrimidin-4-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(2-oxo-hexahydro-pyrimidin-5-yl)-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(1,3-dimethyl-2-oxo-hexahydro-pyrimidin-5-yl)-benzamide;  
 Biphenyl-3,4′-dicarboxylic acid 4′-{[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-amide} 3-[(2-methoxy-ethyl)-amide];  
 Biphenyl-3,4′-dicarboxylic acid 4′-{[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-amide} 3-[(2-morpholin-4-yl-ethyl)-amide];  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(4-methylpiperazin-1-yl)pyrimidin-4-yl]benzamide;  
 4-[(4-{4-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethylcarbamoyl]phenyl}pyrimidin-2-yl)methlamino]butyric acid;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(2,2,2-trifluoroethoxy)pyrimidin-4-yl]benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(2-pyrrolidin-1-ylpyrimidin-4-yl)benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(2-hydroxymethylpyrrolidin-1-yl)-pyrimidin-4-yl]benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(carbamoylmethyl-N-methylamino)-pyrimidin-4-yl]benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(6-pyrrolidin-1-yl-hexylamino)pyrimidin-4-yl]benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(6-piperidin-1-ylhexylamino)pyrimidin-4-yl]benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(4-piperidin-1-ylbutylamino)pyrimidin-4-yl]benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(4-diethylaminobutylamino)pyrimidin-4-yl]benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(6-morpholin-4-ylhexylamino)pyrimidin-4-yl]benzamide; N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(6-dimethylaminohexylamino)pyrimidin-4-yl]benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(4-dimethylaminobutylamino)pyrimidin-4-yl]benzamide;  
 4-[2-(Bicyclo[2;2;1]hept-2-ylamino)pyrimidin-4-yl]-N-[2-(3-carbamimidoyl-1H-indol-5-yl)ethyl]benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-{2-[(2-hydroxy-ethyl)-N-methylamino]pyrimidin-4-yl}benzamide;  
 N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(2-morpholin-4-yl-pyrimidin-4-yl)-benzamide;  
 N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(cyclopropylmethyl-amino)-pyrimidin-4-yl]-benzamide;  
 N-[2-(carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-[(2-methoxy-ethyl)-methyl-amino]-pyrimidin-4-yl]-benzamide;  
 N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(3-hydroxy-propylamino)-pyrimidin-4-yl]-benzamide;  
 N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[(2-hydroxy-ethyl)-propyl-amino]-pyrimidin-4-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indole-5yl)-ethyl]-4-(2-piperidin-1-yl-pyrimidin-4-yl)-benzamide;  
 N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(ethyl-methyl-amino)-pyridin-4-yl]-benzamide;  
 N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(4-hydroxy-piperidin-1-yl)-pyrimidin-4-yl]-benzamide;  
 N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(2,3-dihydroxy-propylamino)-pyridin-4-yl]-benzamide;  
 N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-[(2,3-dihydroxy-propyl)-methyl-amino]-pyrimidin-4-yl]-benzamide;  
 N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-((s)-2-methoxy]ethyl-pyrrolidin-1-yl)-pyrimidin-4-yl-benzamide;  
 N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(2-piperazin-1-yl-pyrimidin-4-yl)-benzamide;  
 N-[2-(3-carbamimidoyl-1H-indol-5-yl)-4-[2-[2-(2-oxo-imidazolidin-1-yl)-ethylamino]-pyrimidin-4-yl]-benzamide;  
 N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(3-methoxy-propylamino)-pyrimidin-4-yl]-benzamide;  
 4-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(2-hydroxy-ethylamino)-pyrimidin-4-yl]-benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)-ethyl]-4-[2-(2-methoxyethoxy)-pyridin-4-yl]benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(1-carbamoylethoxy)pyrimidin-4-yl]benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(6-dimethylaminohexyloxy)pyrimidin-4-yl]benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[2-(2-pyrrolidin-1-yl-ethoxy)pyrimidin-4-yl]benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-ylethyl]-4-[2-(2-dimethylaminoethoxy)pyrimidin-4-yl]benzamide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-(1-oxypyridin-2-yl)benzamide;  
 2′-(2-Dimethylaminoethoxy)biphenyl-4-carboxylic acid [2-(3-carbamimidoyl-1H-indol-5-yl)ethyl]amide;  
 2′-(3-Dimethylaminopropoxy)biphenyl-4-carboxylic acid [2-(3-carbamimidoyl-1H-indol-5-yl)ethyl]amide;  
 N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-4-(1-oxo-pyridin-3-yl)-benzamide;  
 4-[2-(acetylamino-methyl)-pyridin-4-yl]-N-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethyl]-benzamide;  
 Piperidine-4-carboxylic acid (4-[4-[2-(3-carbamimidoyl-1H-indol-5-yl)-ethylcarbamoyl]-phenyl-]-pyridin-2-ylmethyl)-amide;  
 N-[2-(3-Carbamimidoyl-1H-indol-5-yl)ethyl]-4-[1-(3-dimethylaminopropyl)-6-oxo-1,6-dihydropyridin-3-yl]benzamide;  
 4-(2-Amino-1,1-dimethylethyl)-N-(2-[3-carbamimidoylindol-5-yl]ethyl)benzamide; and  
 N-(2-[3-Carbamimidoylindol-5-yl]ethyl)-4-pyrid-4-ylbenzamide.  
 
     
     
         30 . A pharmaceutical composition comprising a pharmaceutically effective amount of a compound according to  claim 1  and a pharmaceutically acceptable carrier.  
     
     
         31 . A method for treating a patient suffering from a physiological condition capable of being modulated by inhibiting activity of Factor Xa comprising administering to said patient a pharmaceutically effective amount of a compound according to  claim 1 .  
     
     
         32 . The method according to  claim 31  wherein the physiological condition is abnormal thrombus formation, acute myocardial infarction, unstable angina, thromboembolism, acute vessel closure associated with thrombolytic therapy, percutaneous transluminal coronary angioplasty, transient ischemic attacks, stroke, intermittent claudication or bypass grafting of the coronary or peripheral arteries, vessel luminal narrowing, restenosis post coronary or venous angioplasty, maintenance of vascular access patency in long-term hemodialysis patients, pathologic thrombus formation occurring in the veins of the lower extremities following abdominal, knee or hip surgery, a risk of pulmonary thromboembolism, or of disseminated systemic intravascular coagulopathy occurring in vascular systems during septic shock, certain viral infections or cancer.  
     
     
         33 . The method according to  claim 31  wherein the physiological condition is abnormal thrombus formation, acute myocardial infarction, unstable angina, thromboembolism, acute vessel closure associated with thrombolytic therapy, transient ischemic attacks, intermittent claudication or bypass grafting of the coronary or peripheral arteries, restenosis post coronary or venous angioplasty, pathologic thrombus formation occurring in the veins of the lower extremities following abdominal, knee or hip surgery or a risk of pulmonary thromboembolism.  
     
     
         34 . The method according to  claim 31  wherein the physiological condition is stroke, vessel luminal narrowing, maintenance of vascular access patency in long-term hemodialysis patients, or disseminated systemic intravascular coagulopathy occurring in vascular systems during septic shock, certain viral infections or cancer.  
     
     
         35 . A method of inhibiting Factor Xa comprising contacting a Factor Xa inhibitory amount of a compound according to  claim 1  with a composition containing Factor Xa.  
     
     
         36 . A method of inhibiting the formation of thrombin comprising contacting a Factor Xa inhibitory amount of a compound according to  claim 1  with a composition containing Factor Xa.