New process

Abstract

There is provided a process for the production of a N-protected azetidine-2-carboxylic acid, which process comprises the steps of: (a) addition of base to an aqueous solvent comprising an organic acid addition salt of an azetidine-2-carboxylic acid; and (b) addition of protecting agent to the resultant reaction mixture.

1 . A process for the production of a N-protected azetidine-2-carboxylic acid, which process comprises the steps of: (a) addition of base to an aqueous solvent comprising an organic acid addition salt of an azetidine-2-carboxylic acid; and (b) addition of protecting agent to the resultant reaction mixture.  
     
     
         2 . A process as claimed in  claim 1 , characterised in that the organic acid is a tartaric acid.  
     
     
         3 . A process as claimed in  claim 2 , characterised in that the tartaric acid is D-tartaric acid.  
     
     
         4 . A process as claimed in any one of the preceding claims, characterised in that the azetidine-2-carboxylic acid is azetidine-2-carboxylic acid.  
     
     
         5 . A process as claimed in  claim 4 , characterised in that the azetidine-2-carboxylic acid is L-azetidine-2-carboxylic acid.  
     
     
         6 . A process as claimed in any one of the preceding claims, characterised in that the salt is L-azetidine-2-carboxylic acid-D-tartrate.  
     
     
         7 . A process as claimed in any one of the preceding claims, characterised in that the protecting agent provides a tert-butyloxycarbonyl group.  
     
     
         8 . A product obtainable by a process according to any one of  claims 1  to  7 .